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公开(公告)号：EP2999799A2
公开(公告)日：2016-03-30
申请号：EP14800459.1
申请日：2014-05-22
发明人： BELLOVIN, David , BAKER, Kevin , BRENNAN, Thomas , PANDITE, Arundathy Nirmalini , MOOKERJEE, Bijoyesh , DEYOUNG, Maurice P. , KUMAR, Rakesh
CPC分类号： A61K38/179 , A61K31/337 , A61K31/519 , A61K31/555 , A61K33/24 , A61K45/06 , C07K14/71 , C07K2319/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/574 , G01N33/57496 , G01N2333/49 , G01N2333/50 , G01N2333/503 , G01N2333/515 , G01N2800/52
摘要： Methods of treating cancers comprising administering a fibroblast growth factor receptor 1 (FGFR1) extracellular domain (ECD) and/or an FGFR1 ECD fusion molecule are provided. Methods of treating cancers comprising administering a fibroblast growth factor receptor 1 (FGFR1) extracellular domain (ECD) and/or an FGFR1 ECD fusion molecule and at least one anti-angiogenic agent are provided.
摘要翻译： 提供了治疗癌症的方法，包括施用成纤维细胞生长因子受体1（FGFR1）胞外结构域（ECD）和/或FGFR1 ECD融合分子。 提供了治疗癌症的方法，包括施用成纤维细胞生长因子受体1（FGFR1）胞外结构域（ECD）和/或FGFR1ECD融合分子和至少一种抗血管生成剂。
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公开(公告)号：EP3252171A1
公开(公告)日：2017-12-06
申请号：EP17177845.9
申请日：2014-05-22
发明人： BELLOVIN, David , BAKER, Kevin , BRENNAN, Thomas , PANDITE, Arundathy Nirmalini , MOOKERJEE, Bijoyesh , DEYOUNG, Maurice P. , KUMAR, Rakesh
CPC分类号： A61K38/179 , A61K31/337 , A61K31/519 , A61K31/555 , A61K33/24 , A61K45/06 , C07K14/71 , C07K2319/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/574 , G01N33/57496 , G01N2333/49 , G01N2333/50 , G01N2333/503 , G01N2333/515 , G01N2800/52
摘要： The invention relates to methods of treating mesothelioma comprising administering a fibroblast growth factor receptor 1 (FGFR1) extracellular domain (ECD) and/or an FGFR1 ECD fusion molecule and at least one therapeutic agent selected from pemetrexed, cisplatin, paclitaxel, carboplatin, and docetaxel are provided.
摘要翻译： 本发明涉及治疗间皮瘤的方法，其包括施用成纤维细胞生长因子受体1（FGFR1）胞外结构域（ECD）和/或FGFR1 ECD融合分子和选自培美曲塞，顺铂，紫杉醇，卡铂和多西他赛的至少一种治疗剂 被提供。
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公开(公告)号：EP3601353A1
公开(公告)日：2020-02-05
申请号：EP18718990.7
申请日：2018-03-29
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , A61K39/00
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公开(公告)号：EP3212670A1
公开(公告)日：2017-09-06
申请号：EP15798264.6
申请日：2015-10-28
发明人： WONG, Brian , HAMBLETON, Julie , SIKORSKI, Robert , MASTELLER, Emma , HESTIR, Kevin , BELLOVIN, David , LEWIS, Katherine E.
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
CPC分类号： C07K16/2866 , A61K2039/505 , A61K2039/507 , A61K2039/54 , A61K2039/545 , C07K16/2803 , C07K16/2818 , C07K16/3046 , C07K16/3069 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/76 , C07K2317/90 , C07K2317/92
摘要： Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSF1R) in combination with PD-1/PD-L1 inhibitors are provided.
摘要翻译： 提供了用结合集落刺激因子1受体（CSF1R）与PD-1 / PD-L1抑制剂组合的抗体治疗癌症的方法。
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公开(公告)号：EP3283527A1
公开(公告)日：2018-02-21
申请号：EP16718802.8
申请日：2016-04-12
发明人： MASTELLER, Emma , BRENNAN, Thomas , BELLOVIN, David , BAKER, Kevin , WONG, Brian
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
CPC分类号： A61K47/6879 , A61K47/6851 , A61K51/1084 , A61K2039/507 , A61P35/00 , C07K16/2866 , C07K16/2878
摘要： Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSF1R) in combination with one or more immune stimulating agents are provided.
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公开(公告)号：EP3209688A1
公开(公告)日：2017-08-30
申请号：EP15790387.3
申请日：2015-10-21
发明人： BORGES, Luis , SALLEE, Nathan , KAPLAN, Charles , BRACE, Arthur , KAVANAUGH, W. Michael , WONG, Brian , BELLOVIN, David , BRENNAN, Thomas , KARASYOV, Artur
IPC分类号： C07K16/28
CPC分类号： C12N5/0636 , C07K16/2803 , C07K16/2896 , C07K2317/76 , C07K2319/30 , C12N2501/599 , G01N33/505
摘要： Methods of identifying and using SLAMF1 antagonists are provided.
摘要翻译： 提供了鉴定和使用SLAMF1拮抗剂的方法。
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公开(公告)号：EP3964527A2
公开(公告)日：2022-03-09
申请号：EP20212116.6
申请日：2016-04-12
发明人： MASTELLER, Emma , BRENNAN, Thomas , BELLOVIN, David , BAKER, Kevin , WONG, Brian
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
摘要： Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSFIR) in combination with one or more immune stimulating agents are provided.
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8.发明公开
公开(公告)号：EP3681535A1
公开(公告)日：2020-07-22
申请号：EP18779538.0
申请日：2018-09-12
发明人： LEWIS, Katherine E. , PERNA, Serena , CARLETON, Michael , XU, Ke , PHILLIPS, Penny , PANDYA, Dimple , WONG, Brian , HAMBLETON, Julie , SIKORSKI, Robert , MASTELLER, Emma , HESTIR, Kevin , BELLOVIN, David , POWERS, Janine , LEE, Ernestine
IPC分类号： A61K39/395 , A61K45/06 , C07K16/28 , A61K39/00
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公开(公告)号：EP3964527A3
公开(公告)日：2022-06-15
申请号：EP20212116.6
申请日：2016-04-12
发明人： MASTELLER, Emma , BRENNAN, Thomas , BELLOVIN, David , BAKER, Kevin , WONG, Brian
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
摘要： Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSFIR) in combination with one or more immune stimulating agents are provided.
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公开(公告)号：EP3835323A1
公开(公告)日：2021-06-16
申请号：EP20207287.2
申请日：2015-10-28
发明人： WONG, Brian , HAMBLETON, Julie , SIKORSKI, Robert , MASTELLER, Emma , HESTIR, Kevin , BELLOVIN, David , LEWIS, Katherine E.
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
摘要： Methods of treating cancer with antibodies that bind colony stimulating factor 1 receptor (CSF1R) in combination with PD-1/PD-L1 inhibitors are provided.
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