公开(公告)号：EP3856887A1

公开(公告)日：2021-08-04

申请号：EP19783227.2

申请日：2019-09-23

申请人： FRAUNHOFER-GESELLSCHAFT zur Förderung der angewandten Forschung e.V.

发明人： ZIMMERMANN, Heiko ,  NEUBAUER, Julia ,  GEPP, Michael

IPC分类号： C12M1/00 ,  C12M1/12

公开(公告)号：EP3894076A1

公开(公告)日：2021-10-20

申请号：EP19832849.4

申请日：2019-12-10

申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.

发明人： ZIMMERMANN, Heiko ,  NEUBAUER, Julia ,  MEISER, Ina ,  GEPP, Michael

IPC分类号： B01L3/00

公开(公告)号：EP3849777A1

公开(公告)日：2021-07-21

申请号：EP19758985.6

申请日：2019-08-28

申请人： FRAUNHOFER-GESELLSCHAFT zur Förderung der angewandten Forschung e.V.

发明人： ZIMMERMANN, Heiko ,  NEUBAUER, Julia ,  GEPP, Michael ,  FISCHER, Benjamin

IPC分类号： B29C64/106 ,  B29C64/364 ,  B33Y10/00 ,  B33Y30/00 ,  A61L27/52 ,  C12N5/00

公开(公告)号：EP3623136A1

公开(公告)日：2020-03-18

申请号：EP18194428.1

申请日：2018-09-14

申请人： FRAUNHOFER-GESELLSCHAFT zur Förderung der angewandten Forschung e.V.

发明人： ZIMMERMANN, Heiko ,  NEUBAUER, Julia ,  GEPP, Michael ,  FISCHER, Benjamin

IPC分类号： B29C64/106 ,  B29C64/364 ,  B33Y10/00 ,  B33Y30/00 ,  A61L27/52 ,  C12N5/00

摘要： The invention relates to a method for producing three-dimensional, preferably porous, hydrogel structures (1) by means of layer build-up technique, wherein the method comprises the following steps. Providing (S1) of a liquid hydrogel solution, preferably a liquid alginate solution, and a, preferably transportable, sample carrier. Layerwise applying (S2) the liquid hydrogel solution onto the sample carrier (4) in a temperature environment, the temperature of which is below the freezing point of the hydrogel solution, to produce a frozen 3D layered hydrogel structure (1a). In order to increase advantageously the porosity of the 3D layered hydrogel structure (1a), i.e. the proportion of small voids, cavities and/or depressions in the 3D layered hydrogel structure, the method according to the invention further comprises the step of drying (S3) of the frozen 3D layered hydrogel structure (1a), e.g. by means of freeze-drying, to produce a porous 3D hydrogel structure (1). The invention relates further also to a device (10) for the layerwise building-up of three-dimensional hydrogel structures.

公开(公告)号：EP3027728A1

公开(公告)日：2016-06-08

申请号：EP14744275.0

申请日：2014-07-21

申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.

发明人： ZIMMERMANN, Heiko ,  GEPP, Michael

IPC分类号： C12M1/26 ,  C12M1/00

CPC分类号： C12M33/00 ,  C12M47/04

摘要： The invention relates to a device and a method for detaching biological material, in particular biological cells or proteins, from a surface of a carrier. The device (10) comprises a holding device (11) for receiving at least one carrier (1) of biological material (5), a mechanical stripping device (28) having at least one stripper (30) for mechanically detaching the biological material (5) from the carrier surface, and a vessel (17), which is coupled to the holding device (11) and is arranged in relation to the stripper (30) in such a manner that material detached by the stripper is collected by the vessel (17). The device has at least one connecting element, which is connected via an outlet valve (23, 24) to a collection region (19) of the vessel (17) arranged at the vessel end.

公开(公告)号：EP4333914A1

公开(公告)日：2024-03-13

申请号：EP22726066.8

申请日：2022-04-27

申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. ,  Universität des Saarlandes

发明人： ZIMMERMANN, Heiko ,  GEPP, Michael ,  FISCHER, Benjamin

IPC分类号： A61L27/14 ,  A61L27/22 ,  A61L27/38

公开(公告)号：EP4168534A1

公开(公告)日：2023-04-26

申请号：EP21733774.0

申请日：2021-06-15

申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.

发明人： ZIMMERMANN, Heiko ,  NEUBAUER, Julia ,  GEPP, Michael

IPC分类号： C12N5/00