利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

7 条记录 (耗时 0.012 秒)

    METHODS OF INHIBITING VIRAL INFECTION
    1.
    发明公开
    METHODS OF INHIBITING VIRAL INFECTION 审中-公开
    抑制病毒感染的方法

    公开(公告)号：EP2203065A2

    公开(公告)日：2010-07-07

    申请号：EP08870586.8

    申请日：2008-10-31

    申请人： Functional Genetics, Inc.

    发明人： KINCH, Michael ,  GOLDBLATT, Michael

    IPC分类号： A01N55/02

    CPC分类号： C07D215/44

    摘要： Compounds, pharmaceutical compositions and methods of inhibiting viral infection in a mammal in need of same, are provided, which employ compounds of the formula wherein each X is independently H or an electrodonating group, each Y is independently H, alkyl of 1-4 carbon atoms, hydroxy, alkoxy or methylene and wherein Substituent Z is a di-or-tri akly amino, or alkyl di or tri amino, optionally substituted with a halogen moiety. This family of compounds, designated FGI-104 herein, inhibits viral infection therapeutically and prophylactically.

    摘要翻译： 提供了在需要的哺乳动物中抑制病毒感染的化合物，药物组合物和方法，其使用下式的化合物其中每个X独立地为H或电子化的基团，每个Y独立地为H，1-4个碳的烷基 原子，羟基，烷氧基或亚甲基，并且其中取代基Z为任选被卤素部分取代的二 - 或三 - 氨基氨基或烷基二或三氨基。 本文命名为FGI-104的该化合物家族在治疗上和预防上抑制病毒感染。

    METHODS OF INHIBITING VIRAL INFECTION
    3.
    发明公开
    METHODS OF INHIBITING VIRAL INFECTION 有权
    一种抑制病毒感染

    公开(公告)号：EP2207801A1

    公开(公告)日：2010-07-21

    申请号：EP08842625.9

    申请日：2008-10-23

    申请人： Functional Genetics, Inc.

    发明人： KINCH, Michael ,  GOLDBLATT, Michael

    IPC分类号： C07K16/00

    CPC分类号： A61K31/4745 ,  A61K31/131 ,  A61K31/155 ,  A61K31/4184

    摘要： A method of inhibiting viral infection in a mammal in need of same, includes administering an effective amount of at least one of the compounds of FGI- 103 which are represented by 273, 365 and 510 either prophylactically to prevent viral infection, or therapeutically following viral infection. These compounds appear to selectively inhibit Caspase 8 as a method of preventing infective viral particle release. They can be administered IV, IP, orally or via other conventional administration routes. The compounds are highly effective, requiring relatively low dosages on the order of 1 ng/kg - 200 mg/kg of body weight.

    HUMAN FG01 GENE AND ITS APPLICATIONS
    6.
    发明公开
    HUMAN FG01 GENE AND ITS APPLICATIONS 有权
    人类基因FG01及其应用

    公开(公告)号：EP2427766A1

    公开(公告)日：2012-03-14

    申请号：EP09844461.5

    申请日：2009-09-25

    申请人： Functional Genetics, Inc.

    发明人： LI, Wu-Bo ,  KINCH, Michael ,  GOLDBLATT, Michael

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6896 ,  C07K14/4711 ,  G01N2800/2821

    摘要： A human gene, fg01, on chromosome 8, is identified. This gene, and its expression product, human fg01, shares a homology under 70% with the corresponding murine gene, which has been linked to presentation of the Alzheimer's phenotype of Aβ plaques and hyperphosphorylated tau tangles. Upregulation appears to suppress the Alzheimer's phenotype, which may be effective in preventing the onset of symptoms or progression of symptoms associated with AD. Screening methods are also set forth.

    THERAPEUTIC TARGETING OF ESCORT PROTEINS
    7.
    发明公开
    THERAPEUTIC TARGETING OF ESCORT PROTEINS 审中-公开
    ESCORT蛋白的治疗靶向

    公开(公告)号：EP2091971A2

    公开(公告)日：2009-08-26

    申请号：EP07864323.6

    申请日：2007-11-13

    申请人： Functional Genetics, Inc.

    发明人： DUAN, Roxanne ,  KINCH, Michael ,  GOLDBLATT, Michael

    IPC分类号： C07K16/08 ,  G01N33/577

    CPC分类号： C07K16/18

    摘要： The invention provides for inhibition of viral disease by the provision to a mammalian host of antibodies directed against an escort protein likeTsg101. These proteins appear on the surface of a cell, and thus can be bound by circulating antibodies thereto. By binding escort proteins on the cell surface, budding of viral particles is inhibited. The virus infects the initial cells, but cannot escape that cell to infect the body en masse.