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    Therapeutic targeting of escort proteins
    1.
    发明公开
    Therapeutic targeting of escort proteins 审中-公开
    靶向von Escort-Proteinen的治疗

    公开(公告)号：EP2360182A1

    公开(公告)日：2011-08-24

    申请号：EP11000692.1

    申请日：2007-11-13

    申请人： Functional Genetics, Inc.

    发明人： Duan, Roxanne ,  Kinch, Michael ,  Goldblatt, Michael

    IPC分类号： C07K16/18 ,  A61K39/395 ,  A61P31/12

    CPC分类号： C07K16/18

    摘要： The invention provides for inhibition of viral disease by the provision to a mammalian host of antibodies directed against an escort protein like Tsg101. These proteins appear on the surface of a cell, and thus can be bound by circulating antibodies thereto. By binding escort proteins on the cell surface, budding of viral particles is inhibited. The virus infects the initial cells, but cannot escape that cell to infect the body en masse.

    摘要翻译： 本发明通过向哺乳动物宿主提供针对诸如Tsg101之类的护送蛋白的抗体来提供对病毒性疾病的抑制。 这些蛋白质出现在细胞表面，因此可以通过循环其抗体而结合。 通过在细胞表面结合护送蛋白，病毒颗粒的出芽被抑制。 病毒感染初始细胞，但不能逃避该细胞大量感染身体。

    RANDOM HOMOZYGOUS GENE PERTURBATION TO ENHANCE ANTIBODY PRODUCTION
    4.
    发明公开
    RANDOM HOMOZYGOUS GENE PERTURBATION TO ENHANCE ANTIBODY PRODUCTION 有权
    改进产生抗体RHGP（RANDOM纯合子基因摄）

    公开(公告)号：EP2078075A2

    公开(公告)日：2009-07-15

    申请号：EP07874242.6

    申请日：2007-10-30

    申请人： Functional Genetics, Inc.

    发明人： DUAN, Roxanne ,  GOLDBLATT, Michael

    IPC分类号： C12N15/01

    CPC分类号： C07K16/00

    摘要： The invention reflects enhanced antibody expression of an antibody of interest by cell lines transformed by random homozygous gene perturbation methods to either increase or decrease the expression pattern of a gene of the cell line other than the antibody of interest. The transformed cell line exhibits specific productivity rates, SPR, for the RHGP transformed cell liens of 1.5 or more, as compared with the antibody expressing cell line parents prior to transformation by RHGP. A knock out or anti-sense construct may be devised to reduce expression of the target gene, a promoter may be inserter to enhance expression of the target gene. The antibodies expressed by the transformed cell lines exhibit the binding properties of their parent cell lines prior to transformation with RHGP, and increase Total Volumetric Production of said antibody by said cells in a given volume.