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9 条记录 (耗时 0.016 秒)

    RANDOM HOMOZYGOUS GENE PERTURBATION TO ENHANCE ANTIBODY PRODUCTION
    1.
    发明公开
    RANDOM HOMOZYGOUS GENE PERTURBATION TO ENHANCE ANTIBODY PRODUCTION 有权
    改进产生抗体RHGP（RANDOM纯合子基因摄）

    公开(公告)号：EP2078075A2

    公开(公告)日：2009-07-15

    申请号：EP07874242.6

    申请日：2007-10-30

    申请人： Functional Genetics, Inc.

    发明人： DUAN, Roxanne ,  GOLDBLATT, Michael

    IPC分类号： C12N15/01

    CPC分类号： C07K16/00

    摘要： The invention reflects enhanced antibody expression of an antibody of interest by cell lines transformed by random homozygous gene perturbation methods to either increase or decrease the expression pattern of a gene of the cell line other than the antibody of interest. The transformed cell line exhibits specific productivity rates, SPR, for the RHGP transformed cell liens of 1.5 or more, as compared with the antibody expressing cell line parents prior to transformation by RHGP. A knock out or anti-sense construct may be devised to reduce expression of the target gene, a promoter may be inserter to enhance expression of the target gene. The antibodies expressed by the transformed cell lines exhibit the binding properties of their parent cell lines prior to transformation with RHGP, and increase Total Volumetric Production of said antibody by said cells in a given volume.

    METHODS OF INHIBITING VIRAL INFECTION
    2.
    发明公开
    METHODS OF INHIBITING VIRAL INFECTION 审中-公开
    抑制病毒感染的方法

    公开(公告)号：EP2203065A2

    公开(公告)日：2010-07-07

    申请号：EP08870586.8

    申请日：2008-10-31

    申请人： Functional Genetics, Inc.

    发明人： KINCH, Michael ,  GOLDBLATT, Michael

    IPC分类号： A01N55/02

    CPC分类号： C07D215/44

    摘要： Compounds, pharmaceutical compositions and methods of inhibiting viral infection in a mammal in need of same, are provided, which employ compounds of the formula wherein each X is independently H or an electrodonating group, each Y is independently H, alkyl of 1-4 carbon atoms, hydroxy, alkoxy or methylene and wherein Substituent Z is a di-or-tri akly amino, or alkyl di or tri amino, optionally substituted with a halogen moiety. This family of compounds, designated FGI-104 herein, inhibits viral infection therapeutically and prophylactically.

    摘要翻译： 提供了在需要的哺乳动物中抑制病毒感染的化合物，药物组合物和方法，其使用下式的化合物其中每个X独立地为H或电子化的基团，每个Y独立地为H，1-4个碳的烷基 原子，羟基，烷氧基或亚甲基，并且其中取代基Z为任选被卤素部分取代的二 - 或三 - 氨基氨基或烷基二或三氨基。 本文命名为FGI-104的该化合物家族在治疗上和预防上抑制病毒感染。

    METHODS OF INHIBITING VIRAL INFECTION
    3.
    发明公开
    METHODS OF INHIBITING VIRAL INFECTION 有权
    一种抑制病毒感染

    公开(公告)号：EP2207801A1

    公开(公告)日：2010-07-21

    申请号：EP08842625.9

    申请日：2008-10-23

    申请人： Functional Genetics, Inc.

    发明人： KINCH, Michael ,  GOLDBLATT, Michael

    IPC分类号： C07K16/00

    CPC分类号： A61K31/4745 ,  A61K31/131 ,  A61K31/155 ,  A61K31/4184

    摘要： A method of inhibiting viral infection in a mammal in need of same, includes administering an effective amount of at least one of the compounds of FGI- 103 which are represented by 273, 365 and 510 either prophylactically to prevent viral infection, or therapeutically following viral infection. These compounds appear to selectively inhibit Caspase 8 as a method of preventing infective viral particle release. They can be administered IV, IP, orally or via other conventional administration routes. The compounds are highly effective, requiring relatively low dosages on the order of 1 ng/kg - 200 mg/kg of body weight.

    HUMAN FG01 GENE AND ITS APPLICATIONS
    7.
    发明公开
    HUMAN FG01 GENE AND ITS APPLICATIONS 有权
    人类基因FG01及其应用

    公开(公告)号：EP2427766A1

    公开(公告)日：2012-03-14

    申请号：EP09844461.5

    申请日：2009-09-25

    申请人： Functional Genetics, Inc.

    发明人： LI, Wu-Bo ,  KINCH, Michael ,  GOLDBLATT, Michael

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6896 ,  C07K14/4711 ,  G01N2800/2821

    摘要： A human gene, fg01, on chromosome 8, is identified. This gene, and its expression product, human fg01, shares a homology under 70% with the corresponding murine gene, which has been linked to presentation of the Alzheimer's phenotype of Aβ plaques and hyperphosphorylated tau tangles. Upregulation appears to suppress the Alzheimer's phenotype, which may be effective in preventing the onset of symptoms or progression of symptoms associated with AD. Screening methods are also set forth.

    RANDOM HOMOZYGOUS GENE PERBURBATION (RHGP) WITH THERMAL ASSYMETRIC INTERLACED (TAIL)-PCR
    8.
    发明公开
    RANDOM HOMOZYGOUS GENE PERBURBATION (RHGP) WITH THERMAL ASSYMETRIC INTERLACED (TAIL)-PCR 审中-公开
    随机同源基因灌木（RHGP）与热协方差交错（尾）-PCR

    公开(公告)号：EP2373340A2

    公开(公告)日：2011-10-12

    申请号：EP10729431.6

    申请日：2010-01-06

    申请人： Functional Genetics, Inc.

    发明人： KINCH, Michael, S. ,  GOLDBLATT, Michael ,  LI, Wu-Bo ,  BAMBA, Douty ,  CHANG, Shaojing ,  CHEN, Huosheng ,  FESSEHA, Zenbework ,  KOHLI, Manu ,  MAO, Hanwen ,  UNG-MEDOFF, Heather Thi Thu ,  WENG, Ke

    IPC分类号： A61K39/395 ,  C12Q1/70 ,  A61P31/16 ,  A61P31/18

    CPC分类号： C07K16/28 ,  C12N15/1082

    摘要： A method for identifying host genes and encoded proteins for potential targets for therapeutic intervention employs a Gene Search Vector that is either lentivirus or MMLV-based, and can be used to interrogate an entire cell genome without prior knowledge of the genomic sequence. This Random Homozygous Gene Perturbation (RUGP) technique is rapidly verifiable and is used to identify potential host targets for intervention for influenza, HIV and other viral infections. Using Thermal Assymetric Interlaced (TAIL) - PCR, the period for identification of promising targets is reduced from months to weeks or less. Specific targets including PTCH1, Robo1 and Nedd4 are reviewed in detail.

    摘要翻译： 用于鉴定宿主基因和编码蛋白质以用于治疗性干预的潜在靶标的方法使用基因搜索载体，该基因搜索载体可以是基于慢病毒或基于MMLV的载体，并且可以在事先不了解基因组序列的情况下用于询问整个细胞基因组。 这种随机纯合基因扰动（RUGP）技术可快​​速验证，用于识别潜在的宿主对流感，HIV和其他病毒感染的干预目标。 使用热量不对称交错（TAIL） - PCR，识别有前景的靶标的时间从几个月缩短到几周或更短。 具体目标，包括PTCH1，Robo1和Nedd4详细审查。

    THERAPEUTIC TARGETING OF ESCORT PROTEINS
    9.
    发明公开
    THERAPEUTIC TARGETING OF ESCORT PROTEINS 审中-公开
    ESCORT蛋白的治疗靶向

    公开(公告)号：EP2091971A2

    公开(公告)日：2009-08-26

    申请号：EP07864323.6

    申请日：2007-11-13

    申请人： Functional Genetics, Inc.

    发明人： DUAN, Roxanne ,  KINCH, Michael ,  GOLDBLATT, Michael

    IPC分类号： C07K16/08 ,  G01N33/577

    CPC分类号： C07K16/18

    摘要： The invention provides for inhibition of viral disease by the provision to a mammalian host of antibodies directed against an escort protein likeTsg101. These proteins appear on the surface of a cell, and thus can be bound by circulating antibodies thereto. By binding escort proteins on the cell surface, budding of viral particles is inhibited. The virus infects the initial cells, but cannot escape that cell to infect the body en masse.