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    METHOD OF PRODUCING LABELED ANTIBODY
    3.
    发明公开
    METHOD OF PRODUCING LABELED ANTIBODY 有权
    VERFAHREN ZUR HERSTELLUNG MARKIERTERANTIKÖRPER

    公开(公告)号：EP2952895A1

    公开(公告)日：2015-12-09

    申请号：EP14746846.6

    申请日：2014-01-29

    申请人： Furukawa Electric Co., Ltd.

    发明人： YAMANAKA, Nobumitsu ,  AIZAWA, Hideki ,  OHKUBO, Michio ,  MIYOSHI, Kazutomi

    IPC分类号： G01N33/531 ,  G01N33/533 ,  G01N33/534 ,  G01N33/547 ,  G01N33/552

    CPC分类号： G01N33/533 ,  G01N33/532 ,  G01N33/54346 ,  G01N33/54353 ,  G01N33/552 ,  Y10T428/2982

    摘要： A method of producing a labeled antibody, including the steps of:
    a) allowing silica nanoparticles containing a functional molecule and having a thiol group on a surface thereof, and a linker molecule containing a maleimido group and an amino group to coexist in a solvent to form a thioether bond between the thiol group and the maleimido group, thereby obtaining functional molecule-containing silica nanoparticles on which the linker molecule is bonded; and
    b) allowing the functional molecule-containing silica nanoparticles on which the linker molecule is bonded, carbodiimide and an antibody to coexist in an aqueous solvent to form an amide bond between the amino group of the linker molecule and a carboxyl group of the antibody.

    摘要翻译： 一种制备标记抗体的方法，包括以下步骤：a）使含有功能性分子的二氧化硅纳米粒子在其表面具有硫醇基，并且含有马来酰亚胺基和氨基的连接分子在溶剂中共存， 在硫醇基和马来酰亚胺基之间形成硫醚键，从而获得其上键合有连接分子的含功能分子的二氧化硅纳米粒子; b）使含有连接子分子键合的含功能分子的二氧化硅纳米粒子，碳二亚胺和抗体共存于含水溶剂中，在连接分子的氨基与抗体的羧基之间形成酰胺键。

    SILICA PARTICLES HAVING REACTIVE FUNCTIONAL GROUP ON SURFACE, AND METHOD FOR PRODUCING THE SAME
    4.
    发明公开
    SILICA PARTICLES HAVING REACTIVE FUNCTIONAL GROUP ON SURFACE, AND METHOD FOR PRODUCING THE SAME 有权
    与其制造表面与方法的反应性官能团二氧化硅粒子

    公开(公告)号：EP3035057A1

    公开(公告)日：2016-06-22

    申请号：EP14836946.5

    申请日：2014-08-08

    申请人： Furukawa Electric Co. Ltd.

    发明人： NISHIDA, Masataka ,  YAMANAKA, Nobumitsu ,  MIYOSHI, Kazutomi ,  OHKUBO, Michio

    IPC分类号： G01N33/552 ,  C09K11/06 ,  G01N33/543

    CPC分类号： G01N33/552 ,  G01N33/54353 ,  G01N33/582

    摘要： Silica particles having a thiol group on a surface thereof, and satisfying the following conditions (a) to (c):
    (a) a particle diameter is 20 to 1,000 nm;
    (b) a density of the thiol group on the surface of the silica particles is 0.002 to 0.2 piece/nm 2 ; and
    (c) a ratio (B/A) in terms of an amount B (piece/particle) of the thiol group existing on the surface of the silica particles to an amount A of sulfur elements in the silica particles (the number of sulfur elements derived from thiol per silica particle) is 0.10 to 0.60.

    摘要翻译： 具有二氧化硅粒子硫醇基在其表面上，并且满足以下条件（a）至（c）：（a）一种颗粒直径为20至1,000nm; （B）硫醇基的二氧化硅颗粒的表面上的密度为0.002〜0.2个/ nm 2以下; 和（c）在二氧化硅粒子在硫元素的量A存在的二氧化硅颗粒的表面上，以（硫的数量的硫醇基团的量B（片/粒）换算的比（B / A） 从硫醇经由二氧化硅粒子派生）元素是十二时10〜0.60。

    IMMUNOCHROMATOGRAPHY, AND DETECTOR AND REAGENT FOR USE THEREIN
    8.
    发明公开
    IMMUNOCHROMATOGRAPHY, AND DETECTOR AND REAGENT FOR USE THEREIN 审中-公开
    雷朋德·维尔多·达林

    公开(公告)号：EP2927688A1

    公开(公告)日：2015-10-07

    申请号：EP13859219.1

    申请日：2013-11-27

    申请人： Furukawa Electric Co., Ltd.

    发明人： AIZAWA, Hideki ,  OHKUBO, Michio ,  MIYOSHI, Kazutomi

    IPC分类号： G01N33/543 ,  G01N21/59 ,  G01N21/64 ,  G01N21/78

    CPC分类号： G01N33/56983 ,  B82Y30/00 ,  G01N21/59 ,  G01N21/6428 ,  G01N21/6489 ,  G01N21/8483 ,  G01N33/558 ,  G01N33/582 ,  G01N2021/6439 ,  G01N2021/8488 ,  G01N2333/08 ,  G01N2333/11 ,  G01N2469/10

    摘要： An immunochromatography for multi-item detection is provided which contains detecting and measuring fluorescence and light absorption respectively at once with a detection device. The immunochromatography contains using fluorescent particles and light absorbing particles, wherein the fluorescence excitation wavelength of the fluorescent particles and the absorption wavelength of the light absorbing particles are in the same wavelength region; and detecting and measuring, at once, the intensity of reflected light from a test area, the intensity of reflected light from another test area, and the intensity of reflected light from a non-test area other than the test areas.

    摘要翻译： 提供了一种用于多项目检测的免疫色谱法，其中包含一次检测和检测荧光和光吸收的检测装置。 免疫色谱法使用荧光粒子和光吸收粒子，其中荧光粒子的荧光激发波长和吸光粒子的吸收波长处于相同的波长区域; 并且一次检测并测量来自测试区域的反射光的强度，来自另一测试区域的反射光的强度以及来自测试区域以外的非测试区域的反射光的强度。