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公开(公告)号：EP3563150A1
公开(公告)日：2019-11-06
申请号：EP17838130.7
申请日：2017-12-22
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公开(公告)号：EP2488295A1
公开(公告)日：2012-08-22
申请号：EP10823690.2
申请日：2010-10-08
IPC分类号： B01J20/289 , B01J39/16 , B01J39/26 , B01J41/12 , B01J41/20
CPC分类号： B01J20/289 , B01D15/3847 , B01J20/287 , B01J20/3285 , B01J39/19 , B01J39/26 , B01J41/13 , B01J41/20 , B01D15/327 , B01D15/362 , B01D15/363
摘要： The present invention relates to separation matrices comprising base matrices with first ligands comprising hydrophobic functions covalently bound to said base matrices and with extenders covalently bound to said base matrices, said extenders comprising second ion exchange ligands.
摘要翻译： 本发明涉及分离基质，其包含具有第一配体的基质基质，所述第一配体包含与所述基础基质共价结合的疏水官能团和与所述基础基质共价结合的延伸剂，所述增量剂包含第二离子交换配体。
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公开(公告)号：EP2155774A1
公开(公告)日：2010-02-24
申请号：EP08767074.1
申请日：2008-06-16
发明人： JOHANSSON, Hans, O. , VAN ALSTINE, James , HJORTH, Rolf , LACKI, Karol , MACEDO, Emmanuel , MALMQUIST, Gunnar , SHANAGAR, Jamil
CPC分类号： C07K1/20 , C08G2650/58 , C08L33/02 , C08L33/08 , C08L33/10 , C08L71/02 , C08L2666/14 , C08L2666/04
摘要： The present invention relates to a liquid mixture comprising a first polymer, which is a poly(acid), a second polymer, which is a poly(ether), and at least one salt, wherein the molecular weight of the poly(acid) is in the range of 1000-100,000 Da. The second polymer is selected to be capable of forming immiscible aqueous phases in the presence of the poly(acid) and salt. The poly(acid) may be selected from the group consisting of poly(acrylic acid) and poly(methacrylic acid), and the second synthetic polymer may comprise ethylene oxide. The invention may be used for separation of biomolecules, cells or particles.
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公开(公告)号：EP2269055A1
公开(公告)日：2011-01-05
申请号：EP09734212.5
申请日：2009-04-20
发明人： BJÖRKESTEN, Lennart , CARREDANO, Enrique , MALMQUIST, Gunnar , RODRIGO, Gustav , STAFSTRÖM, Nils
CPC分类号： B01D15/12 , B01D15/166 , B01D15/361 , G01N30/34 , G01N2030/347
摘要： A method of determining the relative component proportions of at least one each of: a buffer; an acid or a base; a solvent; and optionally a salt, for providing a liquid mix- ture of pre-defined pH and ionic strength, wherein the relative component proportions are determined using the equation of Debye-Hckel, wherein the ion size parameter
α in the Debye-Hckelequation is determined as the weighted mean ion size of all species contributing to the ionic strength of the liquid mixture, and wherein the ionic strength of each species is used as weighting parameter. The present method is also applicable in a method of providing a liquid mixture. Further there is provided a buffer preparation device.摘要翻译： 一种确定以下各项中的至少一个的相对分量比例的方法：缓冲器; 酸或碱; 溶剂; 和任选的盐，用于提供预定pH和离子强度的液体混合物，其中相对组分比例使用Debye-Hckel公式确定，其中Debye-Hckleleation中的离子大小参数α被确定为 所有物质的加权平均离子大小有助于液体混合物的离子强度，并且其中每种物质的离子强度用作加权参数。 本方法也适用于提供液体混合物的方法。 此外提供了一种缓冲液制备装置。
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公开(公告)号：EP3563148A1
公开(公告)日：2019-11-06
申请号：EP17822697.3
申请日：2017-12-22
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公开(公告)号：EP2269055B1
公开(公告)日：2011-11-09
申请号：EP09734212.5
申请日：2009-04-20
发明人： BJÖRKESTEN, Lennart , CARREDANO, Enrique , MALMQUIST, Gunnar , RODRIGO, Gustav , STAFSTRÖM, Nils
CPC分类号： B01D15/12 , B01D15/166 , B01D15/361 , G01N30/34 , G01N2030/347
摘要： A method of determining the relative component proportions of at least one each of: a buffer; an acid or a base; a solvent; and optionally a salt, for providing a liquid mix- ture of pre-defined pH and ionic strength, wherein the relative component proportions are determined using the equation of Debye-Hckel, wherein the ion size parameter
α in the Debye-Hckelequation is determined as the weighted mean ion size of all species contributing to the ionic strength of the liquid mixture, and wherein the ionic strength of each species is used as weighting parameter. The present method is also applicable in a method of providing a liquid mixture. Further there is provided a buffer preparation device.-
公开(公告)号：EP2155773A1
公开(公告)日：2010-02-24
申请号：EP08767073.3
申请日：2008-06-16
发明人： HJORTH, Rolf , LACKI, Karol , MACEDO, Emmanuel , MALMQUIST, Gunnar , SHANAGAR, Jamil , VAN ALSTINE, James
CPC分类号： C07K1/145 , C07K1/20 , C07K1/22 , C08G2650/58 , C08L33/02 , C08L33/06 , C08L33/08 , C08L71/00 , C08L71/02 , C08L2666/14 , C08L2666/04
摘要： The present invention relates to a process of isolating one or more target compounds, wherein the clarification of feed is performed using partitioning in a multiphase system comprising a first polymer, which is a synthetic poly(acid), a second synthetic polymer, which is a poly(ether), and at least one salt, which clarification is followed by at least one step of affinity chromatography. The molecular weight of the poly(acid) may be in the range of 1000-100,000 Da. The target compound is preferably a biomolecule, such as a monoclonal antibody.
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