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公开(公告)号：EP1962911A2
公开(公告)日：2008-09-03
申请号：EP06831371.7
申请日：2006-12-07
IPC分类号： A61K49/00 , A61K49/10 , A61K49/14 , A61K51/04 , A61K103/10 , A61K101/02
CPC分类号： A61K49/0002 , A61K51/0431 , A61K51/0459
摘要： The present invention provides a novel imaging agent suitable for the non-invasive visualization of fibrosis. A method for the preparation of the imaging agent is also provided by the invention, as well as a precursor for use in said method. Also provided is a pharmaceutical composition comprising the imaging agent and a kit for the preparation of the pharmaceutical. In a further aspect, use of the imaging agent for in vivo imaging and in the preparation of a medicament for the diagnosis of a condition in which LOX is upregulated is provided.
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公开(公告)号：EP1957114A2
公开(公告)日：2008-08-20
申请号：EP06831370.9
申请日：2006-12-07
CPC分类号： A61K51/08 , A61K51/0402 , A61K51/088
摘要： The present invention provides a novel imaging agent targeting the mannose-6-phosphate (M6P) receptor suitable for the non-invasive visualization of fibrosis. A method for the preparation of the imaging agent is also provided by the invention, as well as a precursor for use in said method. The invention also provides a pharmaceutical composition comprising the imaging agent and a kit for the preparation of the pharmaceutical composition. In a further aspect, use of the imaging agent for in vivo imaging and in the preparation of a medicament for the diagnosis of a condition in which the mannose-6-phosphate receptor is upregulated is provided.
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公开(公告)号：EP2219681A2
公开(公告)日：2010-08-25
申请号：EP08856281.4
申请日：2008-11-19
发明人： CHETTIBI, Salah , NEWTON, Ben , SOLBAKKEN, Magne
CPC分类号： A61K49/14 , A61K49/0004 , A61K49/085 , A61K51/08 , A61K51/082
摘要： The present invention relates to a method useful in facilitating the identification of fibrogenesis in a subject. The method of the invention is particularly useful when applied as part of a method to diagnose fibrogenesis of the liver. The invention also provides a compound for use in a method for identification of fibrogenesis in a subject A further aspect of the invention is a compound for use in the preparation of a medicament for use in a method for identification of fibrogenesis in a subject.
摘要翻译： 本发明涉及有助于鉴定受试者纤维形成的方法。 当用作诊断肝脏纤维形成的方法的一部分时，本发明的方法特别有用。 本发明还提供了用于在受试者中鉴定纤维形成的方法中使用的化合物。本发明的另一方面是用于制备用于在受试者中鉴定纤维形成的方法中使用的药物的化合物。
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公开(公告)号：EP2440254A2
公开(公告)日：2012-04-18
申请号：EP10723127.6
申请日：2010-06-10
发明人： CHETTIBI, Salah , NEWTON, Ben , SOLBAKKEN, Magne
IPC分类号： A61K51/08
CPC分类号： A61K51/088
摘要： The present invention relates to peptide compounds and their use for in vivo imaging using positron emission tomography (PET). More specifically, the invention relates to the use of such peptide-based compounds in a method for the in vivo imaging of liver fibrosis.
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公开(公告)号：EP1763371A2
公开(公告)日：2007-03-21
申请号：EP04805892.9
申请日：2004-11-26
IPC分类号： A61K51/00 , A61K49/00 , A61K49/06 , A61K49/08 , A61K49/10 , A61K49/12 , A61K49/14 , A61K51/02 , A61K51/04 , A61K51/06 , A61K51/08
CPC分类号： A61K51/0455 , A61K51/0431 , A61K51/0446 , A61K51/0459 , A61K51/088 , Y02P20/582
摘要： The present invention relates to diagnostic imaging agents for in vivo imaging. The imaging agents comprise a synthetic caspase-3 inhibitor labelled with an imaging moiety suitable for diagnostic imaging in vivo. The invention also provides pharmaceutical and radiopharmaceutical compositions comprising the imaging agents, together with kits for the preparation of the radiopharmaceuticals. Also described are chelator conjugates of the caspase-3 inhibitor, which are suitable for the preparation of imaging agents comprising a radioactive or paramagnetic metal ion. The imaging agents are useful for the diagnostic imaging and or therapy monitoring in vivo of various disease states where caspase-3 is involved.
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公开(公告)号：EP2680888B1
公开(公告)日：2017-10-18
申请号：EP12706606.6
申请日：2012-03-02
发明人： IVESON, Peter, Brian , INDREVOLL, Bård , NEWTON, Ben , BHALLA, Rajiv , JOHANNESEN, Edvin, Wilhelm
IPC分类号： A61K51/08
CPC分类号： A61K51/08 , A61K51/088
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公开(公告)号：EP2680888A1
公开(公告)日：2014-01-08
申请号：EP12706606.6
申请日：2012-03-02
发明人： IVESON, Peter, Brian , INDREVOLL, Bård , NEWTON, Ben , BHALLA, Rajiv , JOHANNESEN, Edvin, Wilhelm
IPC分类号： A61K51/08
CPC分类号： A61K51/08 , A61K51/088
摘要： The present invention relates to technetium imaging agents comprising radiolabeled c-Met binding peptides suitable for SPECT or PET imaging in vivo. The c-Met binding peptides are labelled via chelator conjugates. Also disclosed are pharmaceutical compositions, methods of preparation of the agents and compositions, plus methods of in vivo imaging using the compositions, especially for use in the diagnosis of cancer.
摘要翻译： 本发明涉及包含适用于体内SPECT或PET成像的放射性标记的c-Met结合肽的锝显像剂。 c-Met结合肽通过螯合剂缀合物标记。 还公开了药物组合物，制剂的制备方法和组合物，以及使用该组合物的体内成像方法，特别是用于诊断癌症的方法。
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公开(公告)号：EP2026844A2
公开(公告)日：2009-02-25
申请号：EP07732982.9
申请日：2007-05-25
发明人： CHETTIBI, Salah , NEWTON, Ben , HUSBYN, Mette , SOLBAKKEN, Magne , BROWN, Jane GE Healthcare Limited , BHALLA, Rhajiv GE Healthcare Limited , IVESON, Peter GE Healthcare Limited , KRAMER, Daniel
CPC分类号： A61K51/088 , A61K49/0002
摘要： The present invention provides a novel imaging agent suitable for the non-invasive visualization of fibrosis. A precursor for the preparation of the imaging agent is also provided by the invention, as well as a pharmaceutical composition comprising the imaging agent and a kit for the preparation of the pharmaceutical composition. In a further aspect, use of the imaging agent for in vivo imaging and in the preparation of a medicament for the diagnosis of a condition which comprises fibrosis is provided.
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