公开(公告)号：EP2619172A2

公开(公告)日：2013-07-31

申请号：EP11764913.7

申请日：2011-09-20

申请人： GE Healthcare Limited ,  Imperial College

发明人： ABOAGYE, Eric, Ofori ,  ROBINS, Edward, George ,  SMITH, Graham ,  ZHAO, Yongjun ,  LEYTON, Julius ,  TURTON, David ,  WILSON, Anthony ,  BHALLA, Rajiv ,  BRICKUTE, Diana

IPC分类号： C07C213/00 ,  C07C213/02 ,  C07C213/06 ,  C07C215/08 ,  C07C217/10

CPC分类号： A61K51/04 ,  C07B59/001 ,  C07B2200/05 ,  C07C213/08 ,  C07C215/08 ,  C07C215/40 ,  Y10T428/13

摘要： Novel radiotracer(s) for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of disease states related to altered choline metabolism (e.g., tumor imaging of prostate, breast, brain, esophageal, ovarian, endometrial, lung and prostate cancer - primary tumor, nodal disease or metastases). The present invention also describes intermediate(s), pre-cursor(s), pharmaceutical composition(s), methods of making, and methods of use of the novel radiotracer(s).

公开(公告)号：EP2619170A2

公开(公告)日：2013-07-31

申请号：EP11761246.5

申请日：2011-09-20

申请人： GE Healthcare Limited ,  Imperial College

发明人： ABOAGYE, Eric, Ofori ,  ROBINS, Edward George ,  SMITH, Graham ,  LUTHRA, Sajinder

IPC分类号： C07C213/00 ,  C07C213/02 ,  C07C213/06 ,  C07C215/08 ,  C07C217/10

CPC分类号： A61K51/04 ,  C07B59/001 ,  C07B2200/05 ,  C07C215/08 ,  C07C215/40

摘要： Novel choline - derived radiotracer (s) having an isotopic carbon for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of disease states related to altered choline metabolism (e.g., tumor imaging of prostate, breast, brain, esophageal, ovarian, endometrial, lung and prostate cancer - primary tumor, nodal disease or metastases).

公开(公告)号：EP2619171A2

公开(公告)日：2013-07-31

申请号：EP11764402.1

申请日：2011-09-20

申请人： GE Healthcare Limited ,  Imperial College

发明人： ABOAGYE, Eric, Ofori ,  ROBINS, Edward George ,  SMITH, Graham ,  ZHAO, Yongjun

IPC分类号： C07C213/00 ,  C07C213/02 ,  C07C213/06 ,  C07C215/08 ,  C07C217/10

CPC分类号： C07C215/08 ,  C07B2200/05 ,  C07C217/10 ,  C07C309/73

摘要： Novel radiotracer(s) for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of disease states related to altered choline metabolism (e.g., tumor imaging of prostate, breast, brain, esophageal, ovarian, endometrial, lung and prostate cancer - primary tumor, nodal disease or metastases). The present invention also describes intermediate(s), pre-cursor(s), pharmaceutical composition(s), methods of making, and methods of use of the novel radiotracer(s).

公开(公告)号：EP2794520A1

公开(公告)日：2014-10-29

申请号：EP12808813.5

申请日：2012-12-20

申请人： GE Healthcare Limited ,  Imperial Innovations Limited

发明人： LUTHRA, Sajinder, Kaur ,  FORTT, Robin ,  AWAIS, Ramla, Osman ,  ABOAGYE, Eric, Ofori ,  SMITH, Graham

IPC分类号： C07B59/00 ,  C07D403/14 ,  C07D491/10

CPC分类号： C07B59/002 ,  A61K51/0453 ,  C07D403/14 ,  C07D491/10

摘要： The present invention provides a method of radio fluorination of biological targeting molecules (BTMs) with the radioisotope
18 F. Also provided are novel conjugates useful in the
18 F-radio fluorination method, and the use of such conjugates and automated synthesizer apparatus including cassettes for carrying out the method.

摘要翻译： 本发明提供了用放射性同位素18F对生物靶向分子（BTM）进行放射性氟化的方法。 还提供了用于18F-放射性氟化方法的新型缀合物，以及使用这种缀合物和包括盒的自动合成装置用于实施该方法。