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公开(公告)号：EP2619172A2
公开(公告)日：2013-07-31
申请号：EP11764913.7
申请日：2011-09-20
发明人： ABOAGYE, Eric, Ofori , ROBINS, Edward, George , SMITH, Graham , ZHAO, Yongjun , LEYTON, Julius , TURTON, David , WILSON, Anthony , BHALLA, Rajiv , BRICKUTE, Diana
IPC分类号： C07C213/00 , C07C213/02 , C07C213/06 , C07C215/08 , C07C217/10
CPC分类号： A61K51/04 , C07B59/001 , C07B2200/05 , C07C213/08 , C07C215/08 , C07C215/40 , Y10T428/13
摘要： Novel radiotracer(s) for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of disease states related to altered choline metabolism (e.g., tumor imaging of prostate, breast, brain, esophageal, ovarian, endometrial, lung and prostate cancer - primary tumor, nodal disease or metastases). The present invention also describes intermediate(s), pre-cursor(s), pharmaceutical composition(s), methods of making, and methods of use of the novel radiotracer(s).
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公开(公告)号：EP2766326B1
公开(公告)日：2019-11-27
申请号：EP12781296.4
申请日：2012-10-15
发明人： NAIRNE, Robert, James, Domett , BHALLA, Rajiv , KHAN, Imtiaz , BROWN, Jane , WILSON, Anthony , BLACK, Andrew
IPC分类号： C07C319/20 , C07C319/14 , C07C303/30 , C07C227/16 , C07C67/10 , C07D451/02 , C07B59/00 , B01L3/00 , A61K51/04
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3.发明公开HER2 BINDING PEPTIDES LABELED WITH ALUMINIUM-[18]FLUORIDE COMPLEXED BY NOTA 审中-公开麻省理工学院化学工程公司 - [18] - 流感病毒HER2-BINDENDE肽
公开(公告)号：EP2654804A1
公开(公告)日：2013-10-30
申请号：EP11804897.4
申请日：2011-12-19
发明人： HISCOCK, Duncan , INDREVOLL, Bard , IVESON, Peter , GLASER, Matthias, Eberhard , BHALLA, Rajiv , WILSON, Anthony
IPC分类号： A61K51/08 , A61K101/02 , C07K14/31
CPC分类号： A61K51/088 , C07B59/008 , C07K14/31 , C07K14/71 , C07K16/32
摘要： Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
摘要翻译： 包含与放射核子和螯合剂缀合的分离的多肽的成像剂; 其中所述分离的多肽特异性结合HER2或其变体; 以及制备和使用这些成像剂的方法。
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公开(公告)号：EP2717985A1
公开(公告)日：2014-04-16
申请号：EP12797562.1
申请日：2012-06-07
发明人： IDDON, Lisa , BHALLA, Rajiv , WILSON, Anthony
IPC分类号： B01D3/00
CPC分类号： B01D3/009 , B01J19/004 , B01J2219/00006 , B01J2219/00011
摘要： A click chemistry process to be performed with an automated synthesis device using a synthesis cassette includes the steps of performing a chemical reaction in a first vessel at a first elevated temperature, heating the first vessel to a second elevated temperature to cause distillation, delivering a distilled reaction product from the first vessel to a second vessel, performing a click chemistry reaction with the distilled reaction product in the second vessel, purifying the click chemistry product, and formulating a final product from the purified click chemistry product. A cassette and a kit of parts for performing the process are also provided.
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公开(公告)号：EP2766325B1
公开(公告)日：2020-03-18
申请号：EP12781295.6
申请日：2012-10-15
发明人： BHALLA, Rajiv , WILSON, Anthony , KHAN, Imtiaz , BROWN, Jane
IPC分类号： A61K51/04 , C07C303/30 , C07D451/02 , C07C227/16 , C07C67/10 , C07C319/14 , C07B59/00
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公开(公告)号：EP2766325A1
公开(公告)日：2014-08-20
申请号：EP12781295.6
申请日：2012-10-15
发明人： BHALLA, Rajiv , WILSON, Anthony , KHAN, Imtiaz , BROWN, Jane
IPC分类号： C07B59/00 , C07C67/10 , C07C213/08 , C07C227/16 , C07C229/36 , C07C269/06 , C07C271/18 , C07C271/34 , C07C319/14 , C07C323/03 , C07C323/44 , C07C323/58
摘要： The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present invention provides numerous advantages over the prior art methods. One less purification step is required as compared with known methods. Also, one less reagent is required as a particular reagent is employed in two different steps. The chemistry process is thereby simplified, the cost of goods is reduced and the burden of validation and documentation of reagents required for GMP clinical production is minimized.
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7.发明公开HER2 BINDING PEPTIDES LABELLED WITH A 18F - CONTAINING ORGANOSILICON COMPOUND 审中-公开WITH A 18F-含有机硅化合物标记的HER2结合肽
公开(公告)号：EP2661284A1
公开(公告)日：2013-11-13
申请号：EP11805725.6
申请日：2011-12-19
发明人： HISCOCK, Duncan , INDREVOLL, Bard , IVESON, Peter , GLASER, Matthias Eberhard , BHALLA, Rajiv , WILSON, Anthony
IPC分类号： A61K51/08 , A61K101/02 , C07K14/31
CPC分类号： A61K51/088 , C07K14/31
摘要： Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
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