-
1.USING TRUNCATED GUIDE RNAS (TRU-GRNAS) TO INCREASE SPECIFICITY FOR RNA-GUIDED GENOME EDITING 审中-公开
标题翻译: 简明RNAS(TRU GRNAS)用于改进制导GEMONEDITIERUNG RNA的特异性公开(公告)号:EP2971125A4
公开(公告)日:2016-08-24
申请号:EP14763916
申请日:2014-03-14
申请人: GEN HOSPITAL CORP
发明人: JOUNG J KEITH , SANDER JEFFRY D , FU YANFANG , MAEDER MORGAN
CPC分类号: C12N9/22 , C07K14/005 , C07K14/195 , C07K2319/00 , C07K2319/01 , C07K2319/80 , C12N9/0071 , C12N9/1007 , C12N9/16 , C12N9/96 , C12N15/01 , C12N15/102 , C12N15/1031 , C12N15/11 , C12N15/63 , C12N15/85 , C12N2310/20 , C12N2710/00033 , C12N2770/00033 , C12N2800/80 , C12Y114/11 , C12Y201/01 , C12Y301/00 , C12Y301/21004
摘要: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.
摘要翻译: 方法增加RNA引导的基因组编辑,E. G.的特异性,使用CRISPR / Cas9系统编辑,使用截短的RNA导(TRU-gRNAs)。
-
公开(公告)号:EP2879693A4
公开(公告)日:2016-04-13
申请号:EP13797024
申请日:2013-05-29
申请人: GEN HOSPITAL CORP
发明人: JOUNG J KEITH , MAEDER MORGAN , ANGSTMAN JAMES
IPC分类号: A61K38/17 , A61K48/00 , A61P9/00 , A61P25/18 , A61P35/00 , C07K14/435 , C07K19/00 , C12N15/62
CPC分类号: C12N9/0071 , C07K2319/80 , C07K2319/81
摘要: Fusion proteins comprising a DNA binding domain, e.g., a TAL effector repeat array or zinc finger, and a catalytic domain comprising a sequence that catalyzes hydroxylation of methylated cytosines in DNA, and methods of use thereof.
-
3.INCREASING SPECIFICITY FOR RNA-GUIDED GENOME EDITING 审中-公开
标题翻译: SPEZIFITÄTSERHÖHUNGFÜRRNA-VERMITTELTEGEMONÄNDERUNG公开(公告)号:EP2970208A4
公开(公告)日:2016-11-30
申请号:EP14764117
申请日:2014-03-14
申请人: GEN HOSPITAL CORP
发明人: JOUNG J KEITH , ANGSTMAN JAMES , SANDER JEFFRY D , MAEDER MORGAN , TSAI SHENGDAR
CPC分类号: C12N9/22 , C07K14/005 , C07K14/195 , C07K2319/00 , C07K2319/01 , C07K2319/80 , C12N9/0071 , C12N9/1007 , C12N9/16 , C12N9/96 , C12N15/01 , C12N15/102 , C12N15/1031 , C12N15/11 , C12N15/63 , C12N15/85 , C12N2310/20 , C12N2710/00033 , C12N2770/00033 , C12N2800/80 , C12Y114/11 , C12Y201/01 , C12Y301/00 , C12Y301/21004
摘要: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems, using truncated guide RNAs (tru-gRNAs).
摘要翻译: 使用截短的引导RNA(tru-gRNA)增加RNA指导基因组编辑的特异性的方法,例如使用CRISPR / Cas9系统的编辑。
-
公开(公告)号:EP2954042A4
公开(公告)日:2016-10-12
申请号:EP14749683
申请日:2014-02-07
申请人: GEN HOSPITAL CORP
发明人: JOUNG J KEITH , MAEDER MORGAN
CPC分类号: C12N15/635 , C07K14/005 , C07K14/195 , C07K14/435 , C07K14/4702 , C07K2319/80 , C12N2710/16622 , G01N33/5308 , G06F19/18
摘要: Computer programs, algorithms, and methods for identifying TALE-activator binding sites, and methods for generation and use of TALE-activators that bind to said sites.
摘要翻译: 用于鉴定TALE-激活物结合位点的计算机程序,算法和方法,以及用于产生和使用结合所述位点的TALE-活化剂的方法。
-
5.USING RNA-GUIDED FOKI NUCLEASES (RFNS) TO INCREASE SPECIFICITY FOR RNA-GUIDED GENOME EDITING 有权
标题翻译: 使用RNA引导的FOLI核酸(RFNS)增加RNA-LED成分的特异性公开(公告)号:EP2971041A4
公开(公告)日:2016-09-07
申请号:EP14764159
申请日:2014-03-14
申请人: GEN HOSPITAL CORP
发明人: JOUNG J KEITH , TSAI SHENGDAR
CPC分类号: C12N9/22 , C07K14/005 , C07K14/195 , C07K2319/00 , C07K2319/01 , C07K2319/80 , C12N9/0071 , C12N9/1007 , C12N9/16 , C12N9/96 , C12N15/01 , C12N15/102 , C12N15/1031 , C12N15/11 , C12N15/63 , C12N15/85 , C12N2310/20 , C12N2710/00033 , C12N2770/00033 , C12N2800/80 , C12Y114/11 , C12Y201/01 , C12Y301/00 , C12Y301/21004
摘要: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.
-
6.RNA-GUIDED TARGETING OF GENETIC AND EPIGENOMIC REGULATORY PROTEINS TO SPECIFIC GENOMIC LOCI 审中-公开
标题翻译: 遗传和表观遗传调节蛋白在特定基因组基因座上的RNA驱动靶向公开(公告)号:EP2970986A4
公开(公告)日:2016-09-07
申请号:EP14768877
申请日:2014-03-14
申请人: GEN HOSPITAL CORP
发明人: JOUNG J KEITH , MAEDER MORGAN
CPC分类号: C12N9/22 , C07K14/005 , C07K14/195 , C07K2319/00 , C07K2319/01 , C07K2319/80 , C12N9/0071 , C12N9/1007 , C12N9/16 , C12N9/96 , C12N15/01 , C12N15/102 , C12N15/1031 , C12N15/11 , C12N15/63 , C12N15/85 , C12N2310/20 , C12N2710/00033 , C12N2770/00033 , C12N2800/80 , C12Y114/11 , C12Y201/01 , C12Y301/00 , C12Y301/21004
摘要: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.
-
7.METHODS OF TRANSCRIPTION ACTIVATOR LIKE EFFECTOR ASSEMBLY 审中-公开
标题翻译: 方法TRANSCRIPTIONAKTIVATORÄHNLICHEN执行器组件学报公开(公告)号:EP2732038A4
公开(公告)日:2015-07-29
申请号:EP12814750
申请日:2012-07-12
申请人: GEN HOSPITAL CORP
发明人: JOUNG J KEITH , SANDER JEFFRY D
IPC分类号: C12N15/66 , C07K14/24 , C07K19/00 , C12N1/00 , C12N5/00 , C12N15/31 , C12N15/62 , C12Q1/68 , C40B40/06
CPC分类号: C07K14/195 , C07K2319/00 , C07K2319/24 , C07K2319/41 , C07K2319/43 , C07K2319/80 , C12N9/22 , C12N15/1093 , C12N15/66 , C12P19/34 , C12P21/02 , C12Q1/6806 , C12Y301/00 , C40B40/08 , C40B50/06 , C12Q2521/501 , C12Q2563/149
-
-
-
-
-
-