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公开(公告)号:EP0579758A4
公开(公告)日:1995-11-02
申请号:EP92910874
申请日:1992-04-06
申请人: GEN HOSPITAL CORP
发明人: SEGRE GINO V , KRONENBERG HENRY M , ABOU-SAMRA ABDUL-BADI , JUPPNER HARALD , POTTS JOHN T JR , SCHIPANI ERNESTINA
IPC分类号: A01K67/027 , A61K38/00 , A61K39/00 , A61K39/395 , A61P3/00 , A61P3/02 , A61P3/14 , A61P5/12 , C07K5/00 , C07K7/06 , C07K7/08 , C07K14/435 , C07K14/635 , C07K14/705 , C07K14/72 , C07K16/00 , C07K16/28 , C12N1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/113 , C12N15/12 , C12N15/85 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/91 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/68 , G01N33/78 , G01N33/84 , C12P21/06 , A61K35/14 , A61K37/24 , A61K37/36 , C07H15/12 , C07H17/00 , C07K3/00 , C12N5/00 , C12N15/00
CPC分类号: C12N15/1138 , A01K2217/05 , A01K2227/30 , A01K2267/02 , A61K38/00 , C07K14/635 , C07K14/705 , C07K14/72 , C07K14/721 , C07K16/2869 , C12N15/8509 , G01N33/78 , G01N33/84 , G01N2800/04 , G01N2800/046
摘要: DNA encoding a parathyroid hormone receptor; production and isolation of recombinant and synthetic parathyroid hormone receptor polypeptides and fragments; antibodies to parathyroid hormone receptors and receptor fragments; methods for screening candidate compounds for antagonistic or agonistic effects on parathyroid hormone receptor action; and diagnostic and therapeutic methods of these compounds are disclosed.
摘要翻译: 编码甲状旁腺激素受体的DNA; 生产和分离重组和合成的甲状旁腺激素受体多肽和片段; 抗甲状旁腺激素受体和受体片段的抗体; 用于筛选候选化合物对甲状旁腺激素受体作用的拮抗或激动作用的方法; 并公开了这些化合物的诊断和治疗方法。