公开(公告)号：EP1613660B1

公开(公告)日：2012-12-19

申请号：EP04759921.2

申请日：2004-04-16

申请人： Genentech, Inc.

发明人： ACKERLY, Heidi ,  ASHKENAZI, Avi ,  EBERHARD, David ,  FRANTZ, Gretchen ,  FRENCH, Dorothy ,  FUH, Germaine ,  HONGO, Jo-Anne ,  LEE, Chingwei ,  MARSTERS, Scot ,  PITTI, Robert ,  RAAB, Helga ,  SOROCEANU, Liliana ,  VARFOLOMEEV, Evgeny ,  WOLF, Beni

IPC分类号： C07K16/44 ,  C07K14/47 ,  G01N33/53 ,  A61P35/00 ,  C12N15/12 ,  C12N15/63 ,  C12N15/09 ,  A61K31/7088 ,  C07K19/00

CPC分类号： C07K16/32 ,  C07K16/22 ,  C07K16/4283 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622

公开(公告)号：EP1639000A2

公开(公告)日：2006-03-29

申请号：EP04777475.7

申请日：2004-07-02

申请人： GENENTECH, INC.

发明人： ASHKENAZI, Avi ,  CAIRNS, Belinda ,  DOWD, Patrick ,  FRANTZ, Gretchen ,  FRENCH, Dorothy ,  GONZALEZ, Lino ,  POLAKIS, Paul ,  SMITH, Victoria ,  WOLF, Beni ,  WU, Thomas, D. ,  ZHANG, Zemin

IPC分类号： C07K14/47

CPC分类号： C07K16/30 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6843 ,  A61K47/6851 ,  A61K2039/505

摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：EP1589997A2

公开(公告)日：2005-11-02

申请号：EP04708670.7

申请日：2004-02-05

申请人： GENENTECH, INC.

发明人： FRANTZ, Gretchen ,  HILLAN, Kenneth ,  POLAKIS, Paul ,  WOLF, Beni ,  WU, Thomas ,  ZHANG, Zemin

IPC分类号： A61K39/395 ,  A61P35/00 ,  A61K47/48

CPC分类号： C07K16/30

摘要： The present invention is directed to the identification of various cellular polypeptides (and their encoding nucleic acids or fragments thereof) which are expressed to a greater degree on the surface of or by one or more types of cancer cell(s) as compared to on the surface of or by one or more types of normal non-cancer cells. Alternatively, such polypeptides are expressed by cells which produce and/or secrete polypeptides having a potentiating or growth-enhancing effect on cancer cells. Again alternatively, such polypeptides may not be overexpressed by tumor cells as compared to normal celles of the same tissue type, but rather may be specifically expressed by both tumor cells and normal cells of only a single or very limited number of tissue types (preferably tissues which are not essential for life, e.g. prostate, etc.).

公开(公告)号：EP1943257A2

公开(公告)日：2008-07-16

申请号：EP06760294.6

申请日：2006-05-18

申请人： GENENTECH, INC.

发明人： COHEN, Frederick ,  FAIRBROTHER, Wayne, J. ,  QUAN, Clifford ,  SUTHERLIN, Daniel P. ,  WOLF, Beni

IPC分类号： C07F5/02 ,  A61K31/00 ,  A61P35/00

CPC分类号： C07F5/025

摘要： Amino terminus-blocked peptide boronate compounds of Formulas (I) and (II) are useful for inhibiting Fibroblast Activation Protein (FAP) and other proteases, and for treating disorders mediated by FAP. Methods of using the amino terminus blocked peptide boronate compounds, and stereoisomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：EP1613660A2

公开(公告)日：2006-01-11

申请号：EP04759921.2

申请日：2004-04-16

申请人： GENENTECH, INC.

发明人： ACKERLY, Heidi ,  ASHKENAZI, Avi ,  EBERHARD, David ,  FRANTZ, Gretchen ,  FRENCH, Dorothy ,  FUH, Germaine ,  HONGO, Jo-Anne ,  LEE, Chingwei ,  MARSTERS, Scot ,  PITTI, Robert ,  RAAB, Helga ,  SOROCEANU, Liliana ,  VARFOLOMEEV, Evgeny ,  WOLF, Beni

IPC分类号： C07K16/44 ,  C07K14/47 ,  G01N33/53 ,  A61P35/00 ,  C12N15/12 ,  C12N15/63 ,  C12N15/09 ,  A61K31/7088 ,  C07K19/00

CPC分类号： C07K16/32 ,  C07K16/22 ,  C07K16/4283 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622

摘要： The present invention provides novel polypeptides, antibodies, antagonists, agonists, potentiators, nucleic acid molecules, compositions and methods relating to the STOP-1 polypeptide that are useful for treating and preventing diseases and for medical diagnosis and research. The present invention also provides consensus sequences and specific sequences for antibodies that specifically bind to STOP-1 that are useful in the methods described herein.