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1.发明公开
公开(公告)号：EP1784416A2
公开(公告)日：2007-05-16
申请号：EP05791578.7
申请日：2005-07-15
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , GENVEC, INC.
发明人： NABEL, Gary, J. , HUANG, Yue , XU, Ling , CHAKRABARTI, Bimal , Wu, Lan , YANG, Zhi-yong , GALL, Jason, G., D. , King, C., Richter
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/57 , A61K2039/70 , C07K14/005 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12N2740/16222 , C12N2740/16234 , C12N2740/16271 , C12N2740/16322 , C12N2740/16334 , C12N2740/16371
摘要： The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided.
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公开(公告)号：EP1737885A2
公开(公告)日：2007-01-03
申请号：EP05778761.6
申请日：2005-04-12
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , GENVEC, INC.
IPC分类号： C07K14/16
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/57 , C12N7/00 , C12N15/86 , C12N2710/10343 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234
摘要： The invention provides a method of inducing an immune response against a human immunodeficiency virus (HIV) in a mammal. The method comprises administering to the mammal an adenoviral vector composition comprising one or more adenoviral vectors encoding two or more different HIV antigens, the production of which induces an immune response against HIV in the mammal. The invention also provides an adenoviral vector composition comprising four adenoviral vectors encoding an HIV clade A Env protein, an HIV clade B Env protein, an HIV clade C Env protein, and a fusion protein comprising an HIV clade B Gag protein and Pol protein, respectively.
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公开(公告)号：EP1802762A2
公开(公告)日：2007-07-04
申请号：EP05812347.2
申请日：2005-10-17
申请人： GENVEC, INC. , THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
IPC分类号： C12N15/86
CPC分类号： A61K39/0011 , A61K39/385 , A61K47/64 , A61K47/646 , A61K2039/53 , A61K2039/6075 , C07K14/005 , C12N15/86 , C12N2710/10322 , Y02A50/386 , Y02A50/412
摘要： The invention provides a gene transfer vector and a conjugate comprising at least three contiguous amino acids of a shaft region of a subgroup C adenovirus fiber protein. The invention also provides methods of using the gene transfer vector and the conjugate to induce an immune response in a mammal, and to deliver a protein or a non-proteinaceous molecule to a specific cell type.
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4.发明授权
公开(公告)号：EP1784416B1
公开(公告)日：2011-10-05
申请号：EP05791578.7
申请日：2005-07-15
申请人： GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , GENVEC, INC.
发明人： NABEL, Gary, J. , HUANG, Yue , XU, Ling , CHAKRABARTI, Bimal , WU, Lan, VRC/NIAID/NIH , YANG, Zhi-yong , GALL, Jason, G., D. , King, C., Richter
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/57 , A61K2039/70 , C07K14/005 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12N2740/16222 , C12N2740/16234 , C12N2740/16271 , C12N2740/16322 , C12N2740/16334 , C12N2740/16371
摘要： The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided.
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