公开(公告)号：EP1802762A2

公开(公告)日：2007-07-04

申请号：EP05812347.2

申请日：2005-10-17

申请人： GENVEC, INC. ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： KING, C., Richter ,  GALL, Jason, G., D. ,  NABEL, Gary, J. ,  CHENG, Cheng

IPC分类号： C12N15/86

CPC分类号： A61K39/0011 ,  A61K39/385 ,  A61K47/64 ,  A61K47/646 ,  A61K2039/53 ,  A61K2039/6075 ,  C07K14/005 ,  C12N15/86 ,  C12N2710/10322 ,  Y02A50/386 ,  Y02A50/412

摘要： The invention provides a gene transfer vector and a conjugate comprising at least three contiguous amino acids of a shaft region of a subgroup C adenovirus fiber protein. The invention also provides methods of using the gene transfer vector and the conjugate to induce an immune response in a mammal, and to deliver a protein or a non-proteinaceous molecule to a specific cell type.

公开(公告)号：EP1737885A2

公开(公告)日：2007-01-03

申请号：EP05778761.6

申请日：2005-04-12

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  GENVEC, INC.

发明人： NABEL, Gary, J. ,  CHENG, Cheng ,  KONG, Wing-Pui ,  GALL, Jason, G., D. ,  KING, C., Richter

IPC分类号： C07K14/16

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/57 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16234

摘要： The invention provides a method of inducing an immune response against a human immunodeficiency virus (HIV) in a mammal. The method comprises administering to the mammal an adenoviral vector composition comprising one or more adenoviral vectors encoding two or more different HIV antigens, the production of which induces an immune response against HIV in the mammal. The invention also provides an adenoviral vector composition comprising four adenoviral vectors encoding an HIV clade A Env protein, an HIV clade B Env protein, an HIV clade C Env protein, and a fusion protein comprising an HIV clade B Gag protein and Pol protein, respectively.

公开(公告)号：EP1649028B1

公开(公告)日：2012-08-22

申请号：EP04779179.3

申请日：2004-07-26

申请人： GENVEC, INC. ,  The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services

发明人： GALL, Jason G., D. ,  WICKHAM, Thomas, J. ,  ENRIGHT, William, J. ,  BROUGH, Douglas, E. ,  ZUBER, Mohammed ,  KING, C., Richter ,  NABEL, Gary J. ,  CHENG, Cheng

IPC分类号： C12N15/861 ,  A61K39/235

CPC分类号： C12N15/86 ,  A61K48/00 ,  A61K2039/5256 ,  C07K2319/00 ,  C12N2710/10343 ,  C12N2710/10345

摘要： The invention provides a method of inducing an immune response in a mammal. The method comprises administering to the mammal a non-subgroup C adenoviral vector comprising an adenoviral fiber protein having an amino acid sequence comprising about 80 % or more identity to an amino acid sequence encoding a subgroup C adenoviral fiber protein. The adenoviral vector further comprises a nucleic acid sequence encoding an antigen which is expressed in the mammal to induce an immune response. The invention further comprises a method of producing an adenoviral vector, and a composition comprising a serotype 41 or a serotype 35 adenoviral vector and a carrier. The invention also provides an adenoviral vector comprising a nucleic acid sequence encoding an adenoviral pIX protein operably linked to a heterologous expression control sequence, as well as a method of enhancing the stability and/or packaging capacity of an adenoviral vector.

公开(公告)号：EP1784493A2

公开(公告)日：2007-05-16

申请号：EP05808866.7

申请日：2005-08-30

申请人： The Government of the United States of America as Represented by The Department of Health and Human Services ,  GenVec, Inc.

发明人： NABEL, Gary J. ,  CHENG, Cheng ,  GALL, Jason G. D. ,  WICKHAM, Thomas J., EMD Lexigen Bedford Campus

IPC分类号： C12N15/861 ,  A61K39/00

CPC分类号： C12N15/86 ,  A61K39/00 ,  C12N2710/10343 ,  Y02A50/412

摘要： The invention provides a method of inducing an immune response in a mammal. The method comprises administering to the mammal an adenoviral vector comprising (a) a subgroup C fiber protein wherein a native coxsackievirus and adenovirus receptor (CAR)-binding site is disrupted, (b) a subgroup C penton base protein wherein a native integrin-binding site is disrupted, and (c) a nucleic acid sequence encoding at least one antigen derived from an infectious agent other than an adenovirus which is expressed in the mammal to induce an immune response.