-
公开(公告)号：EP4375279A2
公开(公告)日：2024-05-29
申请号：EP24154495.6
申请日：2020-06-11
发明人： CANALES, Eda Y. , DESAI, Manoj C. , GORMAN, Eric , LI, Jiayao , SAITO, Roland D. , TAYLOR, James G. , WRIGHT, Nathan E.
IPC分类号： C07D401/14
CPC分类号： C07D401/14 , A61P3/00 , A61P35/00 , A61P37/00 , A61P29/00
摘要： The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) of generic Formula (I) and methods of use and manufacture thereof.
-
公开(公告)号：EP2049506B9
公开(公告)日：2016-01-13
申请号：EP07836007.0
申请日：2007-07-06
IPC分类号： C07D277/28 , C07D417/14 , A61K31/427 , A61P31/12
CPC分类号： A61K31/427 , A61K31/426 , A61K31/4402 , A61K31/4535 , A61K31/47 , A61K31/496 , A61K31/5377 , A61K38/005 , A61K38/05 , A61K45/00 , A61K45/06 , C07C209/78 , C07C227/16 , C07C227/18 , C07C315/04 , C07D277/24 , C07D277/28 , C07D277/30 , C07D417/14 , C07K5/06 , C07K5/06026 , C07K5/06034 , C07K5/06052 , A61K2300/00
摘要： The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
-
3.发明公开POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF HIV INFECTIONS 审中-公开多环甲氨基吡啶酮化合物及其在治疗HIV感染中的应用
公开(公告)号：EP3252053A1
公开(公告)日：2017-12-06
申请号：EP17177428.4
申请日：2014-07-11
发明人： JI, Mingzhe , MARTIN, Teresa Alejandra Trejo , DESAI, Manoj C. , JIN, Haolun , PYUN, Hyung-Jung
IPC分类号： C07D471/14 , A61K31/4995 , A61P31/18
CPC分类号： A61K31/4985 , C07D471/14 , C07D471/18
摘要： Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I):
including stereoisomers and pharmaceutically acceptable salts thereof, wherein L, R 1 , R 5 , W, X, Y 1 , Y 2 , and Z are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.摘要翻译： 公开了用于治疗人免疫缺陷病毒（HIV）感染的化合物。 该化合物具有下式（I）：包括其立体异构体和药学上可接受的盐，其中L，R 1，R 5，W，X，Y 1，Y 2和Z如本文所定义。 还公开了与这些化合物的制备和使用有关的方法，以及包含这些化合物的药物组合物。
-
4.发明授权POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF HIV INFECTIONS 有权多环甲氨基吡啶酮化合物及其在治疗HIV感染中的应用
公开(公告)号：EP3019499B1
公开(公告)日：2017-09-06
申请号：EP14745053.0
申请日：2014-07-11
发明人： JI, Mingzhe , MARTIN, Teresa Alejandra Trejo , DESAI, Manoj C. , JIN, Haolun , PYUN, Hyung-Jung
IPC分类号： C07D471/14 , A61K31/4995 , A61P31/18
CPC分类号： A61K31/4985 , C07D471/14 , C07D471/18
摘要： Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein L, R 1 , R 5 , W, X, Y 1 , Y 2 , and Z are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译： 包括其立体异构体及其药学上可接受的盐，其中L，R 5，W，X，Y 1，Y 2和Z如本文所定义。 还公开了与这些化合物的制备和使用有关的方法，以及包含这些化合物的药物组合物。
-
公开(公告)号：EP3210982A1
公开(公告)日：2017-08-30
申请号：EP17155905.7
申请日：2009-12-07
发明人： DESAI, Manoj C. , HALCOMB, Randall L. , HRVATIN, Paul , HUI, Hon Chung , McFADDEN, Ryan , ROETHLE, Paul A. , YANG, Hong
IPC分类号： C07D403/12
CPC分类号： A61K31/519 , A61K31/527 , A61K31/5377 , A61K31/551 , A61K31/573 , A61K31/683 , A61K31/7056 , A61K31/7072 , A61K31/708 , A61K38/16 , A61K38/21 , A61K38/212 , A61K45/06 , C07D403/12 , C07D475/06 , C07D475/08 , C07D475/10 , C07D475/12 , C07D487/04 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/393 , Y02A50/395
摘要： Provided are compounds of Formula Ia:
pharmaceutically acceptable salts thereof, compositions containing such compounds, and such compounds for use in the treatment of a hepatitis B viral infection.摘要翻译： 提供了式Ia化合物：其药学上可接受的盐，含有这些化合物的组合物以及用于治疗乙型肝炎病毒感染的此类化合物。
-
公开(公告)号：EP2049506B1
公开(公告)日：2015-06-17
申请号：EP07836007.0
申请日：2007-07-06
IPC分类号： C07D277/28 , C07D417/14 , A61K31/427 , A61P31/12
CPC分类号： A61K31/427 , A61K31/426 , A61K31/4402 , A61K31/4535 , A61K31/47 , A61K31/496 , A61K31/5377 , A61K38/005 , A61K38/05 , A61K45/00 , A61K45/06 , C07C209/78 , C07C227/16 , C07C227/18 , C07C315/04 , C07D277/24 , C07D277/28 , C07D277/30 , C07D417/14 , C07K5/06 , C07K5/06026 , C07K5/06034 , C07K5/06052 , A61K2300/00
摘要： The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
-
公开(公告)号：EP3983064A1
公开(公告)日：2022-04-20
申请号：EP20751726.9
申请日：2020-06-11
发明人： CANALES, Eda Y. , DESAI, Manoj C. , GORMAN, Eric , LI, Jiayao , SAITO, Roland D. , TAYLOR, James G. , WRIGHT, Nathan E.
IPC分类号： A61P3/00 , A61P29/00 , A61P35/00 , A61P37/00 , C07D401/14
-
8.发明公开POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF HIV INFECTIONS 有权多环CARBAMOYLPYRIDON化合物及其用途为HIV感染治疗
公开(公告)号：EP3019499A1
公开(公告)日：2016-05-18
申请号：EP14745053.0
申请日：2014-07-11
发明人： JI, Mingzhe , MARTIN, Teresa Alejandra Trejo , DESAI, Manoj C. , JIN, Haolun , PYUN, Hyung-Jung
IPC分类号： C07D471/14 , A61K31/4995 , A61P31/18
CPC分类号： A61K31/4985 , C07D471/14 , C07D471/18
摘要： Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein L, R 1 , R 5 , W, X, Y 1 , Y 2 , and Z are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要翻译： 包括立体异构体和其药学上可接受的盐，worin L，R 5，W，X，Y1，Y2，和Z如在定义。 与制备和使用化合物的检测，以及药物组合物，包含测试的化合物相关联的方法，该光盘是游离缺失。
-
公开(公告)号：EP2430014A1
公开(公告)日：2012-03-21
申请号：EP10720970.2
申请日：2010-05-12
发明人： GUO, Hongyan , KATO, Darryl , KIRSCHBERG, Thorstens A. , LIU, Hongtae , LINK, John O. , MITCHELL; Michael L. , PARRISH, Jay P. , SQUIRES, Neil , SUN, Jianyu , TAYLOR, James , BACON, Elizabeth M. , CANALES, Eda , CHO, Aesop , COTTELL, Jeromy J. , DESAI, Manoj C. , HALCOMB, Randall L. , KRYGOWSKI, Evan S. , LAZERWITH, Scott E. , LIU, Qi , MACKMAN, Richard , PYUN, Hyung-Jung , SAUGIER; Joseph H. , TRENKLE, James D. , TSE, Winston C. , VIVIAN, RAndall W. , SCHROEDER; Scott D. , WATKINS, William J. , XU, Lianhong , YANG, Zheng-Yu , KELLAR, Terry , SHENG, Xiaoning , CLARKE; Michael O'Neil Hanrahan , CHOU, Chien-hung , GRAUPE, Michael , JIN, Haolun , MCFADDEN, Ryan , MISH, Michael R. , METOBO, Samuel E. , PHILLIPS, Barton W. , VENKATARAMANI, Chandrasekar , KIM, Chuong U.
IPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/14 , C07D495/04 , A61K31/4188 , A61K31/4178 , A61P31/12
CPC分类号： C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明提供一种药物组合物，其包含：（1）下式化合物或其药学上可接受的盐; （2）NS5B聚合酶抑制剂; 和（3）NS3蛋白酶抑制剂; 并且涉及在丙型肝炎或丙型肝炎相关疾病的预防或治疗性治疗中组合使用（1），（2）和（3）。
-
公开(公告)号：EP4375279A3
公开(公告)日：2024-08-21
申请号：EP24154495.6
申请日：2020-06-11
发明人： CANALES, Eda Y. , DESAI, Manoj C. , GORMAN, Eric , LI, Jiayao , SAITO, Roland D. , TAYLOR, James G. , WRIGHT, Nathan E.
IPC分类号： A61K31/4725 , A61K31/661 , A61P3/00 , A61P29/00 , A61P35/00 , A61P37/00
CPC分类号： A61P3/00 , A61P35/00 , A61P37/00 , A61P29/00 , C07F9/65583 , A61K31/675 , C07D401/14
摘要： The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) of generic Formula (I) and methods of use and manufacture thereof.
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.031 秒)
