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公开(公告)号：EP4375279A3
公开(公告)日：2024-08-21
申请号：EP24154495.6
申请日：2020-06-11
发明人： CANALES, Eda Y. , DESAI, Manoj C. , GORMAN, Eric , LI, Jiayao , SAITO, Roland D. , TAYLOR, James G. , WRIGHT, Nathan E.
IPC分类号： A61K31/4725 , A61K31/661 , A61P3/00 , A61P29/00 , A61P35/00 , A61P37/00
CPC分类号： A61P3/00 , A61P35/00 , A61P37/00 , A61P29/00 , C07F9/65583 , A61K31/675 , C07D401/14
摘要： The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) of generic Formula (I) and methods of use and manufacture thereof.
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公开(公告)号：EP4445900A3
公开(公告)日：2024-10-23
申请号：EP24186082.4
申请日：2022-12-02
发明人： FARAND, Julie , GRAUPE, Michael , GUNEY, Tezcan , KATO, Darryl , LI, Jiayao , LINK, John O. , MACK, James B.C. , MUN, Dong Min , SAITO, Roland D. , WATKINS, William J. , ZHANG, Jennifer R.
IPC分类号： A61P31/18 , C07D401/14 , C07F9/00 , A61K31/4439
摘要： The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of a Retroviridae infection, including an HIV infection.
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公开(公告)号：EP4438123A2
公开(公告)日：2024-10-02
申请号：EP24175054.6
申请日：2023-04-05
发明人： CHU, Hang , GONZALEZ BUENROSTRO, Ana Z. , HAN, Xiaochun , HURTLEY, Anna E. , JIANG, Lan , LI, Jiayao , SCHWARZWALDER, Gregg M. , SHIVAKUMAR, Devleena M. , VON BARGEN, Matthew J. , WU, Qiaoyin , YANG, Hong
IPC分类号： A61P31/18
CPC分类号： C07D498/22 , C07D491/22 , C07D471/22 , C07D497/22 , A61P31/18
摘要： The present disclosure relates generally to compounds, of Formula I:
Also disclosed are pharmaceutical compositions comprising said compounds and methods of making said compounds. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.-
公开(公告)号：EP4321217A2
公开(公告)日：2024-02-14
申请号：EP23205202.7
申请日：2022-01-18
发明人： CHU, Hang , GONZALEZ BUENROSTRO, Ana Z. , GUO, Hongyan , HAN, Xiaochun , HURTLEY, Anna E. , JIANG, Lan , LI, Jiayao , LIN, David W. , MITCHELL, Michael L. , NADUTHAMBI, Devan , SCHWARZWALDER, Gregg M. , SZEWCZYK, Suzanne M. , VON BARGEN, Matthew J. , WU, Qiaoyin , YANG, Hong , ZHANG, Jennifer R.
IPC分类号： A61P31/18
摘要： The present disclosure relates generally to certain tricyclic compounds, pharmaceutical compositions comprising said compounds, and methods of making said compounds and pharmaceutical compositions. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.
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公开(公告)号：EP4375279A2
公开(公告)日：2024-05-29
申请号：EP24154495.6
申请日：2020-06-11
发明人： CANALES, Eda Y. , DESAI, Manoj C. , GORMAN, Eric , LI, Jiayao , SAITO, Roland D. , TAYLOR, James G. , WRIGHT, Nathan E.
IPC分类号： C07D401/14
CPC分类号： C07D401/14 , A61P3/00 , A61P35/00 , A61P37/00 , A61P29/00
摘要： The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) of generic Formula (I) and methods of use and manufacture thereof.
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公开(公告)号：EP4222152A1
公开(公告)日：2023-08-09
申请号：EP21801304.3
申请日：2021-09-29
发明人： CHU, Hang , GUO, Hongyan , JIANG, Lan , LI, Jiayao , LIN, David W. , PYUN, Hyung-Jung , WU, Qiaoyin , YANG, Hong , ZAJDLIK, Adam D. , ZHANG, Jennifer R.
IPC分类号： C07D471/04 , A61P31/18 , A61K31/495
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公开(公告)号：EP4122537A1
公开(公告)日：2023-01-25
申请号：EP22179180.9
申请日：2020-03-20
发明人： CHU, Hang , GONZALEZ BUENROSTRO, Ana Z. , GUO, Hongyan , HAN, Xiaochun , JIANG, Lan , LI, Jiayao , MITCHELL, Michael L. , PYUN, Hyung-Jung , SCHROEDER, Scott D. , SCHWARZWALDER, Gregg M. , SHAPIRO, Nathan D. , SHIVAKUMAR, Devleena M. , WU, Qiaoyin , YANG, Hong , ZHANG, Jennifer R.
IPC分类号： A61P31/18 , C07D471/04 , C07D491/06 , A61K31/4375 , C07D487/06 , C07D487/08 , C07D498/08
摘要： Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I):
including stereoisomers and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , L, W 1 , W 2 , X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.-
公开(公告)号：EP3577118A1
公开(公告)日：2019-12-11
申请号：EP18704797.2
申请日：2018-01-31
发明人： AKTOUDIANAKIS, Evangelos , CANALES, Eda , CURRIE, Kevin S. , KATO, Darryl , LI, Jiayao , LINK, John O. , METOBO, Samuel E. , SAITO, Roland D. , SCHROEDER, Scott D. , SHAPIRO, Nathan , TSE, Winston C. , WU, Qiaoyin , HU, Yunfeng Eric
IPC分类号： C07D471/14 , C07D491/22 , C07D498/14 , C07D519/00 , A61K31/5025 , A61K31/503 , A61P31/12
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公开(公告)号：EP2321319B1
公开(公告)日：2012-03-14
申请号：EP09790816.4
申请日：2009-07-24
发明人： AKTOUDIANAKIS, Evangelos , CELEBI, Azim, Alan , DU, Zhimin , JABRI, Salman, Y. , JIN, Haolun , KIM, Choung, U. , LI, Jiayao , METOBO, Samuel, E. , MISH, Michael, R. , PHILLIPS, Barton, W. , SAUGIER, Joseph, H. , YANG, Zheng-Yu , ZONTE, Catalin, Sebastian
IPC分类号： C07D471/16 , C07D498/16 , A61K31/5383 , A61K31/553 , A61K31/551 , A61K31/4375 , A61P31/18
CPC分类号： C07D498/16 , C07D471/16
摘要： The invention is related to anti-viral compounds of formula (I), compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：EP4445900A2
公开(公告)日：2024-10-16
申请号：EP24186082.4
申请日：2022-12-02
发明人： FARAND, Julie , GRAUPE, Michael , GUNEY, Tezcan , KATO, Darryl , LI, Jiayao , LINK, John O. , MACK, James B.C. , MUN, Dong Min , SAITO, Roland D. , WATKINS, William J. , ZHANG, Jennifer R.
IPC分类号： A61K31/4439
摘要： The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of a Retroviridae infection, including an HIV infection.
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