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    Incubator for automatic analyser
    5.
    发明公开
    Incubator for automatic analyser 有权
    自动分析仪培养箱

    公开(公告)号：EP1614474A2

    公开(公告)日：2006-01-11

    申请号：EP05019228.5

    申请日：1999-04-30

    申请人： GEN-PROBE INCORPORATED

    发明人： Ammann, Kelly G. ,  Burns, Ralph E. ,  Hansberry, Ernest V. ,  Horner, Glenn A. ,  Jakub, Cheryl A. ,  Kling, John E. ,  Nieglos, Donald J. ,  Schneider, Robert E. ,  Smith, Robert J.

    IPC分类号： B01L7/00 ,  G01N35/00

    CPC分类号： C12Q1/6834 ,  B01F9/0001 ,  B01F9/0014 ,  B01F9/0021 ,  B01F2009/0074 ,  B01L7/52 ,  B01L7/5255 ,  B01L9/06 ,  B01L2200/147 ,  B01L2300/1822 ,  B01L2300/1827 ,  B03C1/282 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/26 ,  C12Q1/6813 ,  C12Q1/6832 ,  C12Q2537/10 ,  G01N35/0098 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1065 ,  G01N2035/00356 ,  G01N2035/00524 ,  G01N2035/0437 ,  G01N2035/0455 ,  G01N2035/103 ,  Y10T29/53657 ,  Y10T29/53683 ,  Y10T29/53843 ,  Y10T156/1105 ,  Y10T156/1906 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

    摘要： An incubator for receiving a plurality of reaction receptacles containing reaction fluids and for maintaining the reaction fluids in a temperature controlled environment, said incubator comprising:

    a housing including a receptacle access opening formed therein for allowing movement of a reaction receptacle into or out of said housing through said receptacle access opening;
    a command-responsive closure mechanism connected to said housing in proximal relation to said receptacle access opening, said command-responsive closure mechanism being constructed and arranged to be movable between a closed position and an open position with respect to said receptacle access opening in response to corresponding closure movement commands to prevent or permit access to said housing through said access opening,
    said housing and said command-responsive closure mechanism constituting an enclosure defining an incubation chamber therein;
    a heat source in thermal communication with said incubation chamber;
    a powered fan mechanism disposed within said incubation chamber and constructed and arranged to generate air movement within said incubation chamber to promote a generally uniform temperature distribution internal to said incubation chamber; and
    a receptacle carrier disposed within said incubation chamber and including a plurality of receptacle stations, each of said receptacle stations being constructed and arranged to carry a single reaction receptacle, said receptacle carrier being constructed and arranged to present any of said plurality of receptacle stations in a receptacle transfer position with respect to said access opening.

    摘要翻译： 一种用于容纳多个容纳反应流体的反应容器并用于将反应流体保持在温度受控的环境中的培养箱，所述培养箱包括：壳体，所述壳体包括在其中形成的容器进入开口，用于允许反应容器移入或移出所述壳体 通过所述容器进入开口; 响应于所述壳体以近似于所述容器进入开口的方式连接到所述壳体的命令响应闭合机构，所述命令响应闭合机构被构造并布置成响应于所述命令响应闭合机构而相对于所述容器进入开口在关闭位置和打开位置之间移动 相应的关闭运动命令以防止或允许通过所述进入开口进入所述壳体，所述壳体和所述命令响应闭合机构构成限定其中的孵育室的封闭空间; 与所述孵育室热连通的热源; 动力风扇机构，所述动力风扇机构设置在所述孵育室内并且被构造和布置成在所述孵育室内产生空气移动以促进所述孵育室内部的大致均匀的温度分布; 以及设置在所述孵育室内并包括多个容器站的容器载体，所述容器站中的每一个被构造和布置为承载单个反应容器，所述容器载体被构造和布置成将所述多个容器站中的任一个容纳在 相对于所述进入开口的容器传送位置。

    Automated diagnostic analyzer and method
    7.
    发明公开
    Automated diagnostic analyzer and method 无效
    自动诊断分析

    公开(公告)号：EP1614470A2

    公开(公告)日：2006-01-11

    申请号：EP05015156.2

    申请日：1999-04-30

    申请人： GEN-PROBE INCORPORATED

    发明人： Ammann, Kelly G. ,  Burns, Ralph E. ,  Hansberry, Ernest V. ,  Horner, Glenn A. ,  Jakub, Cheryl A. ,  Kling, John E. ,  Nieglos, Donald J. ,  Schneider, Robert E. ,  Smith, Robert J.

    IPC分类号： B01L7/00 ,  G01N35/00

    CPC分类号： C12Q1/6834 ,  B01F9/0001 ,  B01F9/0014 ,  B01F9/0021 ,  B01F2009/0074 ,  B01L7/52 ,  B01L7/5255 ,  B01L9/06 ,  B01L2200/147 ,  B01L2300/1822 ,  B01L2300/1827 ,  B03C1/282 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/26 ,  C12Q1/6813 ,  C12Q1/6832 ,  C12Q2537/10 ,  G01N35/0098 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1065 ,  G01N2035/00356 ,  G01N2035/00524 ,  G01N2035/0437 ,  G01N2035/0455 ,  G01N2035/103 ,  Y10T29/53657 ,  Y10T29/53683 ,  Y10T29/53843 ,  Y10T156/1105 ,  Y10T156/1906 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

    摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

    摘要翻译： 用于执行多个诊断测定的自动分析仪同时包括多个站或模块，其中对反应容器中包含的流体样品进行测定的离散方面。 分析仪包括用于自动准备标本样品的台站，在规定温度下培养样品规定的时间，预处理分析物分离程序，并确定目标分析物的存在。 自动插座输送系统将反应容器从一个站移动到另一个站。 分析仪还包括用于以机器可接近的方式携带多个样品管和一次性移液管尖端的装置，用于搅拌包含固体支持材料的悬浮液并用于提供用于机器通入的容器的靶捕获试剂的容器的装置，以及 用于在温度受控的环境中容纳试剂容器的装置，并且提供用于机器通入的容器。 执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化过程。 该过程是通过在站之间自动移动含有固体支持材料和流体样品的多个反应容器中的每一个来孵育反应容器的内容物并将与固体支持物结合的靶分析物与流体样品分离的步骤。 在分析物分离步骤之后和在最终孵育步骤之前，将分离的分析物加入扩增试剂。