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1.Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues 审中-公开
标题翻译: 核酸构建体,和细胞,以及用于修改可兴奋组织的电生理功能及其使用方法公开(公告)号:EP2166017A1
公开(公告)日:2010-03-24
申请号:EP08160306.0
申请日:2001-09-05
申请人: GeneGrafts Ltd
发明人: Feld, Yair , Gepstein, Lior , Marom, Shimon , Frank, Meira
CPC分类号: C12N5/0697 , A61K38/00 , A61K48/00 , C07K14/705 , C12N5/0657 , C12N2500/12 , C12N2502/1323 , C12N2502/1329 , C12N2502/99 , C12Q1/6897 , C12Q2565/631
摘要: The present invention concerns a nucleic acid construct comprising (a) a first polynucleotide region encoding at least one functional ion channel or ion transporter when expressed within a cell; and (b) a second polynucleotide region encoding at least one functional gap junction when expressed within said cell.
摘要翻译: 本发明涉及一种核酸构建体,其包含(a)的第一多核苷酸区编码的至少一种官能离子通道或离子转运蛋白当在细胞内过度表达; 和(b)第二多核苷酸区编码的至少一种官能间隙连接,当所述电池内过表达。
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2.Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues 有权
标题翻译: 核酸构建体,和细胞,以及用于修改可兴奋组织的电生理功能及其使用方法公开(公告)号:EP2385056A3
公开(公告)日:2012-02-01
申请号:EP10181137.0
申请日:2001-09-05
申请人: GeneGrafts Ltd
发明人: Feld, Yair , Gepstein, Lior , Marom, Shimon , Frank, Meira
IPC分类号: C07H21/04 , A61K48/00 , C07K14/705 , C12N5/00 , C12N5/02 , C12N15/63 , C12Q1/68 , A61K38/17 , C12N5/16
CPC分类号: C12N5/0697 , A61K38/00 , A61K48/00 , C07K14/705 , C12N5/0657 , C12N2500/12 , C12N2502/1323 , C12N2502/1329 , C12N2502/99 , C12Q1/6897 , C12Q2565/631
摘要: The present invention concerns cells expressing an endogenous ion channel/transporter polypeptide for the treatment of an excitable tissue disorder in a subject in need thereof.
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3.Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues 有权
标题翻译: 核酸构建体,和细胞,以及用于修改可兴奋组织的电生理功能及其使用方法公开(公告)号:EP2385056B1
公开(公告)日:2015-06-10
申请号:EP10181137.0
申请日:2001-09-05
申请人: GeneGrafts Ltd
发明人: Feld, Yair , Gepstein, Lior , Marom, Shimon , Frank, Meira
IPC分类号: C07H21/04 , A61K48/00 , C07K14/705 , C12N5/00 , C12N5/02 , C12N15/63 , C12Q1/68 , A61K38/17 , C12N5/16
CPC分类号: C12N5/0697 , A61K38/00 , A61K48/00 , C07K14/705 , C12N5/0657 , C12N2500/12 , C12N2502/1323 , C12N2502/1329 , C12N2502/99 , C12Q1/6897 , C12Q2565/631
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4.Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues 有权
标题翻译: 核酸构建体,和细胞,以及用于修改可兴奋组织的电生理功能及其使用方法公开(公告)号:EP2385056A2
公开(公告)日:2011-11-09
申请号:EP10181137.0
申请日:2001-09-05
申请人: GeneGrafts Ltd
发明人: Feld, Yair , Gepstein, Lior , Marom, Shimon , Frank, Meira
IPC分类号: C07H21/04 , A61K48/00 , C07K14/705 , C12N5/00 , C12N5/02 , C12N15/63 , C12Q1/68 , A61K38/17 , C12N5/16
CPC分类号: C12N5/0697 , A61K38/00 , A61K48/00 , C07K14/705 , C12N5/0657 , C12N2500/12 , C12N2502/1323 , C12N2502/1329 , C12N2502/99 , C12Q1/6897 , C12Q2565/631
摘要: The present invention concerns cells expressing an endogenous ion channel/transporter polypeptide for the treatment of an excitable tissue disorder in a subject in need thereof.
摘要翻译: 本发明涉及表达内源性离子通道/转运蛋白多肽用于在需要其的受试者中治疗的可兴奋组织病症的细胞。
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