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1.发明授权SKELETAL MUSCLE PERIANGIOBLASTS AND CARDIAC MESANGIOBLASTS, METHOD FOR ISOLATION AND USES THEREOF 有权骨骼肌成骨细胞和心肌样组织细胞，分离方法及其用途
公开(公告)号：EP1991664B1
公开(公告)日：2018-03-28
申请号：EP07711541.8
申请日：2007-02-15
IPC分类号： C12N5/077
CPC分类号： C12N5/0668 , C12N5/0657 , C12N2502/1329
摘要： The present invention discloses the isolation and characterization of cells isolated either from adult skeletal muscle or from adult cardiac muscle. These cells are used for the treatment of muscular disorders including muscular dystrophy and cardiopathics, respectively.
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2.发明授权METHOD FOR PRODUCING CARDIOMYOCYTE SHEET FROM EMBRYONIC STEM CELLS 有权一种用于生产KARDIOMYOZYTENFOLIE胚胎干细胞
公开(公告)号：EP2692859B1
公开(公告)日：2016-12-28
申请号：EP12763936.7
申请日：2012-03-30
IPC分类号： C12N5/071 , A61K35/12 , A61L27/00 , A61P9/00 , A61P43/00 , C12N1/00 , C12N5/0735 , C12N15/09 , A61L27/38 , A61L27/54 , A61K35/34 , A61K35/44
CPC分类号： A61K35/34 , A61K9/70 , A61K35/44 , A61L27/3834 , A61L27/3886 , A61L27/54 , A61L2300/414 , A61L2430/20 , C12N5/0657 , C12N5/0697 , C12N2501/01 , C12N2501/04 , C12N2501/165 , C12N2502/1329 , C12N2502/1347 , C12N2502/28 , C12N2506/02 , A61K2300/00
摘要： The present invention provides a method for producing a myocardial sheet using a group of cells derived from embryonic stem cells. This method is characterized by mixing Flk/KDR positive cells, cardiomyocytes, endothelial cells, and mural cells, all derived from embryonic stem cells, and culturing the mixed cells. Furthermore, the myocardial sheet can be used as a therapeutic agent for heart diseases since VEGF is released from the sheet.
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公开(公告)号：EP2882445A4
公开(公告)日：2016-06-15
申请号：EP13829234
申请日：2013-08-13
发明人： MARBÁN EDUARDO , CHENG KE , IBRAHIM AHMED
IPC分类号： A61K35/34 , A61K9/00 , A61K31/7105 , A61K47/46 , A61P9/10 , C12N5/00 , C12N15/00 , C12N15/11
CPC分类号： C12N15/113 , A61K9/0019 , A61K31/7105 , A61K35/34 , A61K47/42 , A61K47/46 , C12N5/0657 , C12N15/111 , C12N2310/141 , C12N2320/30 , C12N2502/1329 , C12N2502/28 , A61K2300/00
摘要： Several embodiments relate to methods of repairing and/or regenerating damaged or diseased tissue comprising administering to the damaged or diseased tissues compositions comprising exosomes. In several embodiments, the exosomes comprise one or more microRNA that result in alterations in gene or protein expression, which in turn result in improved cell or tissue viability and/or function.
摘要翻译： 几个实施方案涉及修复和/或再生受损或患病组织的方法，其包括对损伤或患病组织施用包含外来体的组合物。 在几个实施方案中，外来体包含一种或多种导致基因或蛋白质表达改变的微小RNA，其又导致改善的细胞或组织活力和/或功能。
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公开(公告)号：EP2844744A2
公开(公告)日：2015-03-11
申请号：EP13713247.8
申请日：2013-02-21
发明人： BRODIE, Chaya , SLAVIN, Shimon
IPC分类号： C12N5/079 , A61P25/00 , A61P25/16 , C12N15/113
CPC分类号： A61K35/30 , A61K35/28 , A61K35/50 , A61K35/51 , C12N5/0622 , C12N15/113 , C12N2310/141 , C12N2320/11 , C12N2330/10 , C12N2501/01 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2501/195 , C12N2501/41 , C12N2501/65 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2506/025 , C12N2506/1353 , C12N2506/1369 , C12N2506/1384 , C12N2506/1392 , C12N2510/00 , C12Q1/6876 , C12Q2600/178
摘要： A method of generating a population of cells useful for treating a nerve disease or disorder in a subject, the method comprising up-regulating a level of at least one exogenous mi RNA in mesenchymal stem cells (MSCs) and/or down-regulating a level of at least one mi RNA using a polynucleotide agent that hybridizes to the mi RNA, thereby generating the population of cells useful for treating the nerve disease or disorder. Isolated populations of cells generated thereby and uses thereof are also provided.
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5.发明公开METHOD FOR PRODUCING CARDIOMYOCYTE SHEET FROM EMBRYONIC STEM CELLS 有权VERFAHREN ZUR HERSTELLUNG EINER KARDIOMYOZYTENFOLIE AUS EMBRYONALEN STAMMZELLEN
公开(公告)号：EP2692859A1
公开(公告)日：2014-02-05
申请号：EP12763936.7
申请日：2012-03-30
IPC分类号： C12N5/071 , A61K35/12 , A61L27/00 , A61P9/00 , A61P43/00 , C12N1/00 , C12N5/0735 , C12N15/09
CPC分类号： A61K35/34 , A61K9/70 , A61K35/44 , A61L27/3834 , A61L27/3886 , A61L27/54 , A61L2300/414 , A61L2430/20 , C12N5/0657 , C12N5/0697 , C12N2501/01 , C12N2501/04 , C12N2501/165 , C12N2502/1329 , C12N2502/1347 , C12N2502/28 , C12N2506/02 , A61K2300/00
摘要： The present invention provides a method for producing a myocardial sheet using a group of cells derived from embryonic stem cells. This method is characterized by mixing Flk/KDR positive cells, cardiomyocytes, endothelial cells, and mural cells, all derived from embryonic stem cells, and culturing the mixed cells. Furthermore, the myocardial sheet can be used as a therapeutic agent for heart diseases since VEGF is released from the sheet.
摘要翻译： 本发明提供使用源自胚胎干细胞的一组细胞产生心肌片的方法。 该方法的特征在于混合来自胚胎干细胞的Flk / KDR阳性细胞，心肌细胞，内皮细胞和壁细胞，并培养混合细胞。 此外，心肌片可以用作心脏病的治疗剂，因为VEGF从片材中释放出来。
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公开(公告)号：EP2215218A4
公开(公告)日：2012-01-18
申请号：EP08841852
申请日：2008-10-21
CPC分类号： C12N5/0657 , A61K2121/00 , C12N5/069 , C12N5/0691 , C12N2501/115 , C12N2501/12 , C12N2501/155 , C12N2502/1329 , C12N2506/02 , C12N2533/52
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7.发明公开Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues 审中-公开核酸构建体，和细胞，以及用于修改可兴奋组织的电生理功能及其使用方法
公开(公告)号：EP2166017A1
公开(公告)日：2010-03-24
申请号：EP08160306.0
申请日：2001-09-05
申请人： GeneGrafts Ltd
发明人： Feld, Yair , Gepstein, Lior , Marom, Shimon , Frank, Meira
CPC分类号： C12N5/0697 , A61K38/00 , A61K48/00 , C07K14/705 , C12N5/0657 , C12N2500/12 , C12N2502/1323 , C12N2502/1329 , C12N2502/99 , C12Q1/6897 , C12Q2565/631
摘要： The present invention concerns a nucleic acid construct comprising (a) a first polynucleotide region encoding at least one functional ion channel or ion transporter when expressed within a cell; and (b) a second polynucleotide region encoding at least one functional gap junction when expressed within said cell.
摘要翻译： 本发明涉及一种核酸构建体，其包含（a）的第一多核苷酸区编码的至少一种官能离子通道或离子转运蛋白当在细胞内过度表达; 和（b）第二多核苷酸区编码的至少一种官能间隙连接，当所述电池内过表达。
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8.发明公开USE OF LATE PASSAGE MESENCHYMAL STEM CELLS (MSCS) FOR TREATMENT OF CARDIAC RHYTHM DISORDERS 审中-公开经久耐用的间充质干细胞用于治疗心律失常
公开(公告)号：EP2049656A4
公开(公告)日：2009-09-02
申请号：EP07836167
申请日：2007-07-20
发明人： GAUDETTE GLENN , POTAPOVA IRINA , BRINK PETER R , COHEN IRA S , ROBINSON RICHARD B , ROSEN MICHAEL R
IPC分类号： C12N5/02 , C12N5/0775
CPC分类号： C12N5/0663 , A61K35/12 , C12N2502/1329 , C12N2510/00 , C12N2510/02
摘要： The present invention provides methods and compositions relating to the use of late passage mesenchymal stem cells (MSCs) for treatment of cardiac rhythm disorders. The late passage MSCs of the invention may be used to provide biological pacemaker activity and/or provide a bypass bridge in the heart of a subject afflicted with a cardiac rhythm disorder. The biological pacemaker activity and/or bypass bridge may be provided to the subject either alone or in tandem with an electronic pacemaker.
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9.发明公开A BIOLOGICAL BYPASS BRIDGE WITH SODIUM CHANNELS, CALCIUM CHANNELS AND/OR POTASSIUM CHANNELS TO COMPENSATE FOR CONDUCTION BLOCK IN THE HEART 审中-公开与钠通道，钙通道和/或钾通道一个线组在心脏生物赔偿绕过桥接
公开(公告)号：EP1917350A4
公开(公告)日：2009-04-22
申请号：EP06824776
申请日：2006-07-21
IPC分类号： C12N15/12 , A61K31/713 , A61K35/12 , A61K38/17 , A61N1/362 , C07K14/705 , C12N5/077 , C12N5/0775 , C12N5/10 , C12N15/63 , C12P21/02
CPC分类号： A61N1/0587 , C12N5/0663 , C12N2502/1329 , C12N2510/00
摘要： This invention provides a bypass bridge comprising a tract of gap junction-coupled cells having a first end and a second end, both ends capable of being attached to two selected sites in a heart so as to allow the conduction of a pacemaker and/or electrical signal/current across the tract between the two sites, wherein the cells functionally express a sodium channel. The invention also provides related methods of making the bypass bridge, methods of implanting same in a heart, and methods of treating a disorder associated with an impaired conduction in a subject's heart.
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10.发明公开CREATION OF A BIOLOGICAL ATRIOVENTRICULAR BYPASS TO COMPENSATE FOR ATRIOVENTRICULAR BLOCK 审中-公开生物房室旁路提出的赔偿块房室GENERATION
公开(公告)号：EP1699523A4
公开(公告)日：2008-05-21
申请号：EP04818062
申请日：2004-12-22
IPC分类号： A61N1/18 , A61L27/38 , C12N5/0775
CPC分类号： A61L27/3873 , A61L27/3834 , A61L27/3895 , C12N5/0663 , C12N2502/1329
摘要： A method of creating an atrioventricular bypass tract for a heart comprises growing mesenchymal stem cells into a strip with two ends, attaching one end of the strip onto the atrium of the heart, and attaching the other end of the strip to the ventricle of the heart, to create a tract connecting the atrium to the ventricle to provide a path for electrical signals generated by the sinus node to propagate across the tract and excite the ventricle.
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