利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

3 条记录 (耗时 0.024 秒)

    FURTHER PRO POLYPEPTIDES AND SEQUENCES THEREOF
    2.
    发明公开
    FURTHER PRO POLYPEPTIDES AND SEQUENCES THEREOF 审中-公开
    进一步的PRO多肽及其序列

    公开(公告)号：EP1144629A2

    公开(公告)日：2001-10-17

    申请号：EP99942557.2

    申请日：1999-09-01

    申请人： Genentech, Inc.

    发明人： BAKER, Kevin ,  GODDARD, Audrey ,  GURNEY, Austin, L. ,  SMITH, Victoria ,  WATANABE, Colin, K. ,  WOOD, William, I.

    IPC分类号： C12N15/12 ,  C07K14/705 ,  C12N15/62 ,  C07K16/28 ,  C12Q1/68 ,  C12N5/10

    摘要： Membrane-bound proteins and receptor molecules have various industrial applications, including as pharmaceutical and diagnostic agents. Receptor immunoadhesins, for instance, can be employed as therapeutic agents to block receptor-ligand interactions. The membrane-bound proteins can also be employed for screening of potential peptide or small molecule inhibitors of the relevant receptor/ligand interaction. Efforts are being undertaken by both industry and academia to identify new, native receptor or membrane-bound proteins. Many efforts are focused on the screening of mammalian recombinant DNA libraries to identifiy the coding sequences for novel receptor or membrane-bound proteins. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

    摘要翻译： 膜结合蛋白和受体分子具有各种工业应用，包括作为药物和诊断剂。 例如，受体免疫粘附素可用作治疗剂以阻断受体 - 配体相互作用。 膜结合蛋白也可用于筛选相关受体/配体相互作用的潜在肽或小分子抑制剂。 工业界和学术界正在努力寻找新的天然受体或膜结合蛋白。 许多努力集中于筛选哺乳动物重组DNA文库以鉴定新受体或膜结合蛋白的编码序列。 本发明涉及新的多肽和编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，结合本发明多肽的抗体以及产生本发明多肽的方法 发明。