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公开(公告)号：EP1490386B1
公开(公告)日：2008-08-13
申请号：EP99912321.9
申请日：1999-03-08
申请人： GENENTECH, INC.
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公开(公告)号：EP1121439B1
公开(公告)日：2006-07-12
申请号：EP99970398.6
申请日：1999-10-05
申请人： GENENTECH, INC.
发明人： ASHKENAZI, Avi , GODDARD, Audrey , GURNEY, Austin, L. , KLEIN, Robert, D. , NAPIER, Mary , WOOD, William, I. , YUAN, Jean
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/00
摘要： The present invention concerns methods and compositions for inhibiting neoplastic cell growth. In particular, the present invention concerns antitumor compositions and methods for the treatment of tumors. The invention further concerns screening methods for identifying growth inhibitory, e.g., antitumor compounds.
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公开(公告)号：EP1490386A2
公开(公告)日：2004-12-29
申请号：EP99912321.9
申请日：1999-03-08
申请人： Genentech, Inc.
发明人： WOOD, William, I. , GODDARD, Audrey , GURNEY, Austin , YUAN, Jean , BAKER, Kevin, P. , CHEN, Jian
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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4.发明公开
公开(公告)号：EP1027434A2
公开(公告)日：2000-08-16
申请号：EP98946090.2
申请日：1998-09-16
申请人： Genentech, Inc.
发明人： WOOD, William, I. , GURNEY, Austin, L. , GODDARD, Audrey , PENNICA, Diane , CHEN, Jian , YUAN, Jean
IPC分类号： C12N15/12 , C12N15/18 , C12N15/52 , C07K14/47 , C07K14/705 , C12N15/62 , C07K16/18 , C07K16/28
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptides molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：EP1250437A2
公开(公告)日：2002-10-23
申请号：EP99955293.8
申请日：1999-06-02
申请人： Genentech, Inc.
发明人： BAKER, Kevin , CHEN, Jian , GODDARD, Audrey , GURNEY, Austin, L. , SMITH, Victoria , WATANABE, Colin, K. , WOOD, William, I. , YUAN, Jean
IPC分类号： C12N15/12 , C07K14/705 , C12N15/62 , C07K16/28
摘要： The present invention is directed to membrane-bound polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：EP1121439A2
公开(公告)日：2001-08-08
申请号：EP99970398.6
申请日：1999-10-05
申请人： Genentech, Inc.
发明人： ASHKENAZI, Avi , GODDARD, Audrey , GURNEY, Austin, L. , KLEIN, Robert, D. , NAPIER, Mary , WOOD, William, I. , YUAN, Jean
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/00
摘要： The present invention concerns methods and compositions for inhibiting neoplastic cell growth. In particular, the present invention concerns antitumor compositions and methods for the treatment of tumors. The invention further concerns screening methods for identifying growth inhibitory, e.g., antitumor compounds.
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7.发明公开
公开(公告)号：EP1114152A2
公开(公告)日：2001-07-11
申请号：EP99946924.0
申请日：1999-09-15
申请人： Genentech, Inc.
发明人： CHEN, Jian , GODDARD, Audrey , GURNEY, Austin, L. , HILLAN, Kenneth , PENNICA, Diane , WOOD, William, I. , YUAN, Jean
CPC分类号： C07K14/47 , C07K2319/00
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新的多肽和编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，结合本发明多肽的抗体以及产生本发明多肽的方法 发明。
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公开(公告)号：EP1037979A2
公开(公告)日：2000-09-27
申请号：EP98960440.0
申请日：1998-12-01
申请人： Genentech, Inc.
发明人： WOOD, William, I. , GODDARD, Audrey , GURNEY, Austin, L. , YUAN, Jean , BAKER, Kevin, P. , CHEN, Jian
IPC分类号： C12N15/12 , C12N15/13 , C12N15/62 , C12N5/10 , C12N1/21 , C12N1/19 , C07K14/47 , C07K16/18 , C12Q1/68
CPC分类号： C07K14/47 , C07K2319/00
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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