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公开(公告)号：EP1919920B1
公开(公告)日：2011-05-18
申请号：EP06813425.3
申请日：2006-08-14
发明人： RAWSON, Thomas, E. , SAFINA, Brian , DOTSON, Jennafer , ALIAGAS-MARTIN, Ignacio , HALLADAY, Jason , LIANG, Jun , RUETH, Matthias , ZHU, Bing-Yan , BROOKFIELD, Frederick , PRIME, Michael , ZHANG, Birong , LI, Jun, M. , Zhou, Aihe
IPC分类号： C07D487/04 , C07D491/04 , A61K31/4155 , A61P35/00
CPC分类号： C07D487/04 , C07D491/04
摘要： The invention provides novel kinase inhibitors that are useful as therapeutic agents for example in the treatment malignancies where the compounds have the general formula: (I) wherein A, X, Y, Z, Ra, Rb, Rc, R1 , R2, R3 and m are defined herein.
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公开(公告)号：EP1919920A2
公开(公告)日：2008-05-14
申请号：EP06813425.3
申请日：2006-08-14
发明人： RAWSON, Thomas, E. , SAFINA, Brian , DOTSON, Jennafer , ALIAGAS-MARTIN, Ignacio , HALLADAY, Jason , LIANG, Jun , RUETH, Matthias , ZHU, Bing-Yan , BROOKFIELD, Frederick , PRIME, Michael , ZHANG, Birong , LI, Jun, M. , Zhou, Aihe.
IPC分类号： C07D487/04 , C07D491/04 , A61K31/4155 , A61P35/00
CPC分类号： C07D487/04 , C07D491/04
摘要： The invention provides novel kinase inhibitors that are useful as therapeutic agents for example in the treatment malignancies where the compounds have the general formula: (I) wherein A, X, Y, Z, Ra, Rb, Rc, R1 , R2, R3 and m are defined herein.
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3.发明公开HETEROCYCLYL PYRIDYL SULFONAMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS 审中-公开杂环基吡啶磺酰胺衍生物及其制造和用作药物的用途
公开(公告)号：EP2079719A1
公开(公告)日：2009-07-22
申请号：EP07819290.3
申请日：2007-10-24
发明人： BROOKFIELD, Frederick , GRIDLEY, Jonathan , KLING, Lothar , PRIME, Michael , REIFF, Ulrike , VON DER SAAL, Wolfgang , VON HIRSCHHEYDT, Thomas
IPC分类号： C07D295/04 , A61K31/496 , A61P35/00
CPC分类号： C07D295/04
摘要： Objects of the present invention are the compounds of formula I, their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明的目的是式I化合物，其药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备，以及上述化合物在对照 或预防诸如癌症之类的疾病。
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4.发明公开PHTHALAZINONE PYRAZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS 审中-公开PHTHALAZINONPYRAZOLDERIVATE，生产与应用，药物活性成分
公开(公告)号：EP1999127A1
公开(公告)日：2008-12-10
申请号：EP07723313.8
申请日：2007-03-16
发明人： BOYD, Edward , BROOKFIELD, Frederick , COURTNEY, Steve , GEORGES, Guy , GOLLER, Bernhard , LIMBERG, Anja , PRIME, Michael , RUEGER, Petra , RUETH, Matthias
IPC分类号： C07D403/12 , C07D401/14 , A61K31/495 , A61P35/00
CPC分类号： C07D403/12 , C07D401/14
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
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