公开(公告)号：EP1578364A2

公开(公告)日：2005-09-28

申请号：EP03768511.2

申请日：2003-09-15

申请人： GENENTECH, INC.

发明人： CHIU, Henry ,  CLARK, Hilary ,  DENNIS, Kathryn ,  FONG, Sherman ,  SCHOENFELD, Jill R. ,  WOOD, William I. ,  WU, Thomas D.

IPC分类号： A61K6/00

CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K14/47

公开(公告)号：EP1546189A2

公开(公告)日：2005-06-29

申请号：EP03749546.2

申请日：2003-09-10

申请人： GENENTECH, INC.

发明人： CHIU, Henry ,  CLARK, Hilary ,  DENNIS, Kathryn ,  FONG, Sherman ,  SCHOENFELD, Jill, R. ,  WILLIAMS, P., Mickey ,  WOOD, William, I. ,  WU, Thomas, D.

IPC分类号： C07K14/00 ,  C07K16/28 ,  C12N15/12 ,  C12N15/63 ,  C12N15/64 ,  C12N15/66

CPC分类号： C12Q1/6883 ,  A61K2039/505 ,  C07K14/47 ,  C12Q2600/158 ,  G01N33/564 ,  G01N2500/10

摘要： The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.

公开(公告)号：EP1572130A2

公开(公告)日：2005-09-14

申请号：EP03763223.9

申请日：2003-07-08

申请人： GENENTECH, INC.

发明人： CHIU, Henry ,  CLARK, Hilary ,  DENNIS, Kathryn ,  FONG, Sherman ,  SCHOENFELD, Jill ,  WOOD, William ,  WU, Thomas

IPC分类号： A61K7/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/4713 ,  G01N33/564

摘要： The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.

公开(公告)号：EP2376535A1

公开(公告)日：2011-10-19

申请号：EP09764997.4

申请日：2009-12-08

申请人： Genentech, Inc. ,  F.Hoffmann-La Roche AG

发明人： IRVING, Bryan ,  CHEUNG, Jeanne ,  CHIU, Henry ,  LEHAR, Sophie, M. ,  MAECKER, Heather ,  MARIATHASAN, Sanjeev ,  WU, Yan

IPC分类号： C07K16/28 ,  A61P35/00 ,  A61K39/395

CPC分类号： C07K16/2827 ,  A61K31/7068 ,  A61K39/00 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/1063 ,  C07K16/22 ,  C07K16/28 ,  C07K16/30 ,  C07K16/3046 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/423 ,  Y02A50/492 ,  A61K2300/00

摘要： The present application relates to anti-PD-L1 antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection ( e.g ., acute and chronic) and tumor immunity.

摘要翻译： 本申请涉及抗PD-L1抗体，编码其的核酸，其治疗组合物及其用途增强T细胞功能以上调细胞介导的免疫应答和治疗T细胞功能障碍性疾病，包括感染（ 例如急性和慢性）和肿瘤免疫。

公开(公告)号：EP1618132A2

公开(公告)日：2006-01-25

申请号：EP04750052.5

申请日：2004-04-08

申请人： GENENTECH, INC.

发明人： BALDWIN, Daryl ,  CLARK, Hilary ,  CHIU, Henry ,  FEDOROWICZ, Grazyna ,  FONG, Sherman ,  GRIMALDI, J., Christopher ,  OUYANG, Wenjun ,  WILLIAMS, P. Mickey

IPC分类号： C07K14/47

CPC分类号： G01N33/56972 ,  C07K14/47 ,  G01N33/6863 ,  G01N2500/00 ,  G01N2800/24 ,  Y02A50/55

摘要： The present invention relates to compositions of matter and methods for the treatment and diagnosis of immune related diseases, including those mediated by cytokines released primarily either Th1 or Th2 cells in response to antigenic stimulation. The present invention further relates to methods for biasing the differentiation of T-cells in either the Th1 subtype or the Th2 subtype based on the relative expression levels of the gene PRO92726, and its agonists or antagonists. The present invention further relates to a method of diagnosing Th1- and Th2-mediated diseases.

公开(公告)号：EP1581169A2

公开(公告)日：2005-10-05

申请号：EP03786587.0

申请日：2003-11-06

申请人： GENENTECH, INC.

发明人： FONG, Sherman ,  DENNIS, Kathryn ,  CLARK, Hilary ,  CHIU, Henry ,  SCHOENFELD, Jill ,  WILLIAMS, P. Mickey ,  WOOD, William I. ,  WU, Thomas D.

IPC分类号： A61K7/00

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.