公开(公告)号：EP1649288A1

公开(公告)日：2006-04-26

申请号：EP04755905.9

申请日：2004-06-24

申请人： GENENTECH, INC.

发明人： BERESINI, Maureen ,  SONG, An

IPC分类号： G01N33/564

CPC分类号： G01N33/564 ,  G01N33/57492 ,  G01N2333/70596

摘要： A method of detecting neutralizing antibodies to a therapeutic antibody such as a CD20 antibody is described. The assay can be used to determine the efficacy of the antibody in a method of immunotherapy.

公开(公告)号：EP1250426A2

公开(公告)日：2002-10-23

申请号：EP00983846.7

申请日：2000-12-01

申请人： Genentech Inc.

发明人： BAKER, Kevin P. ,  BERESINI, Maureen ,  DEFORGE, Laura ,  DESNOYERS, Luc ,  FILVAROFF, Ellen ,  GAO, Wei-Qiang ,  GERRITSEN, Mary E. ,  GODDARD, Audrey ,  GODOWSKI, Paul J. ,  GURNEY, Austin L. ,  SHERWOOD, Steven ,  SMITH, Victoria ,  STEWART, Timothy A. ,  TUMAS, Daniel ,  WATANABE, Colin K. ,  WOOD, William L. ,  ZHANG, Zemin

IPC分类号： C12N15/12 ,  C07K14/47 ,  C07K14/705 ,  C12N15/62 ,  C07K16/18 ,  C07K16/28 ,  G01N33/53 ,  A61K38/17 ,  C12Q1/68

CPC分类号： C07K14/4748 ,  A61K38/00 ,  C07K14/47

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.