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1.发明公开
公开(公告)号：EP1141285A2
公开(公告)日：2001-10-10
申请号：EP99962992.6
申请日：1999-12-01
申请人： Genentech, Inc.
发明人： BOTSTEIN, David , DESNOYERS, Luc , FERRARA, Napoleone , FONG, Sherman , GAO, Wei-Qiang , GODDARD, Audrey , GURNEY, Austin, L. , PAN, James , ROY, Margaret, Ann , STEWART, Timothy, A. , TUMAS, Daniel , WATANABE, Colin, K. , WOOD, William, I.
CPC分类号： C12N9/001 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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2.发明公开METHOD FOR ENHANCING PROLIFERATION OF INNER EAR HAIR CELLS USING LIGANDS FOR HER2 AND/OR HER3 RECEPTORS 审中-公开方法的增长而增长内耳毛细胞中HER2的和/或被用来HER3受体的配体
公开(公告)号：EP1126873A1
公开(公告)日：2001-08-29
申请号：EP99956853.8
申请日：1999-10-28
申请人： Genentech, Inc.
发明人： GAO, Wei-Qiang
IPC分类号： A61K39/00 , A61K39/395 , A61K38/18 , C07K14/475
CPC分类号： C12N5/062 , A61K38/1883 , A61K48/00
摘要： Ligands which bind to the HER2 and/or HER3 receptors are useful as inner-ear-supporting cell growth factors to enhance proliferation-mediated generation of new hair cells.
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3.发明授权in vitro methods and use of pharmaceutical compositions for the TREATMENT OF INNER EAR HAIR CELLS 失效体外方法和使用的药物组合物用于对内耳毛细胞的治疗
公开(公告)号：EP0948349B1
公开(公告)日：2002-12-18
申请号：EP97949346.7
申请日：1997-10-28
申请人： Genentech, Inc.
发明人： GAO, Wei-Qiang
CPC分类号： A61K38/30 , A61K38/1825 , A61K38/1841 , A61K2300/00
摘要： Compositions, methods, and devices are provided for inducing or enhancing the growth, proliferation, regeneration of inner ear tissue, particularly inner ear hair cells. In addition, provided are compositions and methods for prophylactic or therapeutic treatment of a mammal afflicted with an inner ear disorder or condition, particularly for hearing impairments involving hair cell damage, loss, or degeneration, by administration of a therapeutically effective amount of IGF-1 or FGF-2, or their agonists, alone or in combination.
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4.发明公开
公开(公告)号：EP1263948A2
公开(公告)日：2002-12-11
申请号：EP00907314.9
申请日：2000-02-18
申请人： Genentech, Inc.
发明人： ASZKENAZI, Avi J. , BAKER, Kevin P. , BOTSTEIN, David , DESNOYERS, Luc , EATON, Dan L. , FERRARA, Napoleone , FILVAROFF, Ellen , FONG, Sherman , GAO, Wei-Qiang , GERBER, Hanspeter , GERRITSEN, Mary E. , GODDARD, Audrey , GODOWSKI, Paul J. , GRIMALDI, Christopher G. , GURNEY, Austin L. , HILLAN, Kenneth J. , KLJAVIN, Ivar J. , KUO, Sophia S. , NAPIER, Mary A. , PAN, James , PAONI, Nicholas F. , ROY, Margaret Ann , SHELTON, David L. , STEWART, Timothy A. , TUMAS, Daniel , WILLIAMS, P. Mickey , WOOD, William I.
IPC分类号： C12N15/12 , C12N15/63 , C12N5/10 , C12N1/21 , C12N1/19 , C07K14/47 , C07K14/705 , C07K19/00 , C07K16/18 , C07K16/28 , G01N33/68 , G01N33/543 , A61K47/48 , A61K51/08 , A61K38/17
CPC分类号： C07K16/18 , A61K38/00 , A61K47/64 , C07K14/47 , C07K14/4703 , C07K14/705 , C07K14/70578 , C07K16/28 , C07K2317/24 , C07K2319/00 , C12N2799/026 , C12N2799/027
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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5.发明授权CONSTITUTIVELY ACTIVE FORM OF NOTCH1 RECEPTOR OR AN ANTI-NOTCH1 RECEPTOR ANTIBODY FOR THE TREATMENT OF PROSTATE CANCER 有权NOTCH1受体或抗Notch1受体抗体对前列腺癌的治疗组成型活性形式
公开(公告)号：EP1318830B1
公开(公告)日：2012-10-24
申请号：EP01973141.3
申请日：2001-09-17
申请人： Genentech, Inc.
IPC分类号： A61K38/17 , A61K39/395 , G01N33/574 , C12Q1/68 , G01N33/50 , A61P13/08 , A61P35/00
CPC分类号： G01N33/57434 , A61K38/177 , A61K2039/505 , G01N2333/705 , G01N2500/00
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公开(公告)号：EP1250426A2
公开(公告)日：2002-10-23
申请号：EP00983846.7
申请日：2000-12-01
申请人： Genentech Inc.
发明人： BAKER, Kevin P. , BERESINI, Maureen , DEFORGE, Laura , DESNOYERS, Luc , FILVAROFF, Ellen , GAO, Wei-Qiang , GERRITSEN, Mary E. , GODDARD, Audrey , GODOWSKI, Paul J. , GURNEY, Austin L. , SHERWOOD, Steven , SMITH, Victoria , STEWART, Timothy A. , TUMAS, Daniel , WATANABE, Colin K. , WOOD, William L. , ZHANG, Zemin
IPC分类号： C12N15/12 , C07K14/47 , C07K14/705 , C12N15/62 , C07K16/18 , C07K16/28 , G01N33/53 , A61K38/17 , C12Q1/68
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：EP1311662A2
公开(公告)日：2003-05-21
申请号：EP01964006.9
申请日：2001-08-14
申请人： Genentech, Inc.
发明人： GAO, Wei-Qiang , POLAKIS, Paul , SHOU, Jianyong , SMITH, Victoria , SORIANO, Robert , WILLIAMS, P. Mickey , WU, Thomas D. , ZHANG, Zemin
CPC分类号： C07K16/30
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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8.发明公开
公开(公告)号：EP1208195A2
公开(公告)日：2002-05-29
申请号：EP00936172.6
申请日：2000-05-22
申请人： Genentech Inc.
发明人： ASHKENAZI,Avi,J , BAKER,Kevin,P , BOTSTEIN, David , DESNOYERS, Luc , EATON, Dan, L. , FERRARA, Napoleone , FONG, Sherman , GAO, Wei-Qiang , GERBER, Hanspeter , GERRITSEN,Mary, E. , GODDARD, Audrey , GODOWSKI,Paul,J , GURNEY, Austin,L , KLJAVIN, Ivar, J , MATHER,Jennie,P , NAPIER, Mary,A , PAN, James , PAONI, Nicholas,F , ROY, Margaret,Ann , TUMAS, Daniel , WATANABE, Colin,K , WILLIAMS, P, Mickey , WOOD,William, I , ZHANG, Zemin
CPC分类号： C07K14/495 , C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：EP1318830A2
公开(公告)日：2003-06-18
申请号：EP01973141.3
申请日：2001-09-17
申请人： Genentech, Inc.
IPC分类号： A61K38/17 , A61K39/395 , G01N33/574 , C12Q1/68 , G01N33/50 , A61P13/08 , A61P35/00
CPC分类号： G01N33/57434 , A61K38/177 , A61K2039/505 , G01N2333/705 , G01N2500/00
摘要： The present invention is directed to methods of alleviating prostate disorders by activation of the Notch1 receptor. Also provided herein are methods for detecting and diagnosing prostate disorders, wherein the specific disorder is prostate cancer.
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公开(公告)号：EP0948349A1
公开(公告)日：1999-10-13
申请号：EP97949346.0
申请日：1997-10-28
申请人： Genentech, Inc.
发明人： GAO, Wei-Qiang
CPC分类号： A61K38/30 , A61K38/1825 , A61K38/1841 , A61K2300/00
摘要： Compositions, methods, and devices are provided for inducing or enhancing the growth, proliferation, regeneration of inner ear tissue, particularly inner ear hair cells. In addition, provided are compositions and methods for prophylactic or therapeutic treatment of a mammal afflicted with an inner ear disorder or condition, particularly for hearing impairments involving hair cell damage, loss, or degeneration, by administration of a therapeutically effective amount of IGF-1 or FGF-2, or their agonists, alone or in combination.
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