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1.发明授权
公开(公告)号：EP1240325B1
公开(公告)日：2009-09-30
申请号：EP00989401.5
申请日：2000-12-20
申请人： Genentech, Inc.
发明人： CHEN, Jian , FILVAROFF, Ellen , FONG, Sherman , GODDARD, Audrey , GODOWSKI, Paul, J. , GRIMALDI, Christopher, J. , GURNEY, Austin, L. , LI, Hanzhong , HILLAN, Kenneth, J. , TUMAS, Daniel , VAN LOOKEREN, Menno , VANDLEN, Richard, L. , WATANABE, Colin, K. , WILLIAMS, P., Mickey , WOOD, William, I. , YANSURA, Daniel, G.
IPC分类号： C12N15/12 , C07K14/715 , C07K14/54 , C12N15/62 , C07K16/24 , C07K16/28 , A61K31/70 , A61K38/17 , A61K38/20 , A61K39/395 , G01N33/566 , G01N33/53
CPC分类号： C07K14/54 , C07K14/7155
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公开(公告)号：EP1869086A1
公开(公告)日：2007-12-26
申请号：EP06750127.0
申请日：2006-04-13
申请人： GENENTECH, INC.
发明人： DESNOYERS, Luc , FILVAROFF, Ellen
IPC分类号： C07K16/22 , A61K39/395 , A61P35/00 , C07K14/475
CPC分类号： C07K14/475 , A01K2267/0331 , A61K2039/505 , C07K16/22 , C07K2317/76 , C07K2319/21 , C07K2319/30 , C12N2799/026
摘要： Methods and compositions for use in modulating the activity(s) of WISP-1 polypeptide are provided. WISP-1 antagonists include anti-WISP-1 antibodies, WISP-1 immunoadhesins and WISP-1 variants (and fusion proteins thereof) which inhibit or neutralize induction or secretion of HAS2, HA, CD44 or RHAMM by native human WISP-1 polypeptide in at least one type of mammalian cell. The invention also provides methods for in vitro, in situ, and/or in vivo diagnosis and/or treatment of mammalian cells or pathological conditions associated with native WISP-1 polypeptides.
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公开(公告)号：EP1364023A2
公开(公告)日：2003-11-26
申请号：EP01994210.1
申请日：2001-12-07
申请人： Genentech, Inc.
CPC分类号： C07K14/8114 , A61K38/00 , C07K2319/00 , C12N2501/998
摘要： The present invention is directed to novel polypeptides having sequence similarity to human inter-alpha-trypsin inhibitor and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods of using the polypeptide to diagnose and treat damage to cartilage resulting from injury and/or cartilaginous disorders.
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4.发明公开SECRETED AMD TRANSMEMBRANE POLYPEPTIDES AND NUCLEIC ACIDS ENCODING THE SAME 审中-公开分泌的AMD跨膜多肽和编码相同的核酸
公开(公告)号：EP1135495A2
公开(公告)日：2001-09-26
申请号：EP99968054.9
申请日：1999-12-01
申请人： Genentech, Inc.
发明人： BAKER, Kevin, P. , BOTSTEIN, David , EATON, Dan, L. , FERRARA, Napoleone , FILVAROFF, Ellen , GERRITSEN, Mary, E. , GODDARD, Audrey , GODOWSKI, Paul, J. , GRIMALDI, Christopher, J. , GURNEY, Austin, L. , HILLAN, Kenneth, J. , KLJAVIN, Ivar, J. , NAPIER, Mary, a. , ROY, Margaret, Ann , TUMAS, Daniel , WOOD, William, I.
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K16/18 , C07K2317/24 , C07K2319/00 , C07K2319/02
摘要： The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及分泌和跨膜多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，结合本发明多肽的抗体以及产生本发明多肽的方法 发明。
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公开(公告)号：EP1076703B2
公开(公告)日：2010-12-15
申请号：EP99923088.1
申请日：1999-05-14
申请人： Genentech, Inc.
发明人： CHEN, Jian , FILVAROFF, Ellen , GODDARD, Audrey , GURNEY, Austin, L. , LI, Hanzhong , WOOD, William, I.
IPC分类号： C12N15/19 , C07K14/52 , C12N5/10 , C12N1/21 , C12N1/19 , C12Q1/68 , C12N15/62 , C07K16/24 , A61K38/19 , C12Q1/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/52 , C07K14/54 , C07K2319/00 , C07K2319/30 , C12N2799/026
摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders.
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6.发明公开
公开(公告)号：EP1744620A2
公开(公告)日：2007-01-24
申请号：EP05736493.7
申请日：2005-04-12
发明人： BRENNAN, Jane , DESAUVAGE, Frederic , EDWARDS, Joel , FILVAROFF, Ellen , GREWAL, Iqbal , HUANG, Wenhu , IRVING, Bryan , JUNUTULA, Jagath Reddy , KIRCHHOFER, Daniel J. , MONTGOMERY, Chuck , PAYNE, Bobby Joe , PEALE JR., Franklin , PHILLIPS, Heidi , QIAN, Ni Nancy , SHI, Zheng-Zheng , SPARKS, Mary Jean , STALA, Joy , TANG, Tracy Tzu-Ling , VOGEL, Peter , YE, Weilan
IPC分类号： A01K67/027 , C12N15/85 , G01N33/50 , C12N5/10 , C12N15/12 , C12N15/15 , C12N15/24 , C12N15/52 , C12N15/55 , C12N15/57 , A61K49/00
CPC分类号： A01K67/0275 , A01K67/0278 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K49/0008 , C07K14/4703 , C07K14/705 , C12N15/8509
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO256, PRO34421, PRO334, PRO770, PRO983, PRO1009, PRO1107, PRO1158, PRO1250, PRO1317, PRO4334, PRO4395, PRO49192, PRO9799, PRO21175, PRO19837, PRO21331, PRO23949, PRO697 or PRO1480 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
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7.发明公开COMPOSITIONS AND METHODS COMPRISING AN EGFL7 ANTAGONIST FOR MODULATING VASCULAR DEVELOPMENT 审中-公开组合物和方法WITH A EGFL7拮抗剂调制血管发育
公开(公告)号：EP1734998A2
公开(公告)日：2006-12-27
申请号：EP05804788.7
申请日：2005-04-14
申请人： GENENTECH, INC.
IPC分类号： A61K39/395 , C07K16/22
CPC分类号： A61K31/7088 , A61K2039/505 , C07K16/22
摘要： The present invention provides methods of using EGFL7 antagonist to modulate vascular development. Also provided herein are methods of screening for modulators of EGFL7 activity. Furthermore, methods of treatment using EGFL7 antagonists are provided.
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8.发明公开SECRETED AND TRANSMEMBRANE POLYPEPTIDES AND NUCLEIC ACIDS ENCODING THE SAME 审中-公开SEKRETIERTE-和TRANSMEMBRANPOLYPEPTIDE和核酸编码
公开(公告)号：EP1341814A2
公开(公告)日：2003-09-10
申请号：EP01985272.2
申请日：2001-08-29
申请人： GENENTECH, INC.
发明人： BAKER, Kevin P. , EATON, Dan L. , FILVAROFF, Ellen , GODDARD, Audrey , GRIMALDI, J. Christopher , GURNEY, Austin L. , SMITH, Victoria , STEPHAN, Jean-Philippe , WATANABE, Colin K. , WOOD, William I. , ZHANG, Zemin , FONG, Sherman
CPC分类号： C07K14/47 , C07K14/705
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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9.发明公开
公开(公告)号：EP1263948A2
公开(公告)日：2002-12-11
申请号：EP00907314.9
申请日：2000-02-18
申请人： Genentech, Inc.
发明人： ASZKENAZI, Avi J. , BAKER, Kevin P. , BOTSTEIN, David , DESNOYERS, Luc , EATON, Dan L. , FERRARA, Napoleone , FILVAROFF, Ellen , FONG, Sherman , GAO, Wei-Qiang , GERBER, Hanspeter , GERRITSEN, Mary E. , GODDARD, Audrey , GODOWSKI, Paul J. , GRIMALDI, Christopher G. , GURNEY, Austin L. , HILLAN, Kenneth J. , KLJAVIN, Ivar J. , KUO, Sophia S. , NAPIER, Mary A. , PAN, James , PAONI, Nicholas F. , ROY, Margaret Ann , SHELTON, David L. , STEWART, Timothy A. , TUMAS, Daniel , WILLIAMS, P. Mickey , WOOD, William I.
IPC分类号： C12N15/12 , C12N15/63 , C12N5/10 , C12N1/21 , C12N1/19 , C07K14/47 , C07K14/705 , C07K19/00 , C07K16/18 , C07K16/28 , G01N33/68 , G01N33/543 , A61K47/48 , A61K51/08 , A61K38/17
CPC分类号： C07K16/18 , A61K38/00 , A61K47/64 , C07K14/47 , C07K14/4703 , C07K14/705 , C07K14/70578 , C07K16/28 , C07K2317/24 , C07K2319/00 , C12N2799/026 , C12N2799/027
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：EP2257293A2
公开(公告)日：2010-12-08
申请号：EP09716498.2
申请日：2009-03-06
申请人： Genentech, Inc.
IPC分类号： A61K31/517 , A61K39/395 , A61K45/06 , A61P35/00
CPC分类号： A61K31/517 , A61K31/5377 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C12N15/1135 , C12N2310/122 , C12N2320/31 , A61K2300/00
摘要： The present invention relates generally to the fields of molecular biology and growth factor regulation. More specifically, the invention relates to combination therapies for the treatment of pathological conditions, such as cancer comprising a c-met antagonist and a EGFR antagonist.
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