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    Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories
    1.
    发明公开
    Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories 失效
    奈瑟氏球菌属特异性探针和扩增引物对临床标本的快速检测和鉴定

    公开(公告)号：EP2345746A1

    公开(公告)日：2011-07-20

    申请号：EP10181607.2

    申请日：1997-11-04

    申请人： Geneohm Sciences Canada, Inc.

    发明人： Bergeron, Michel G. ,  Picard, Francois ,  Ouellette, Marc ,  Roy, Paul H.

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/689 ,  C07K14/195 ,  C07K14/21 ,  C07K14/212 ,  C07K14/245 ,  C07K14/26 ,  C07K14/285 ,  C07K14/31 ,  C07K14/315 ,  C07K14/3156 ,  C12Q1/6895 ,  C12Q2600/156

    摘要： DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample DNA from (i) any bacterium, (ii) the species Streptococcus agalactiae, Staphylococcus saprophyticus, Enterococcus faecium, Neisseria meningitidis, Listeria monocytogenes and Candida albicans, and (iii) any species of the genera Streptococcus, Staphylococcus, Enterococcus, Neisseria and Candida are disclosed. DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample antibiotic resistance genes selected from the group consisting of bla tem , bla rob , bla shv , bla oxa , blaZ, aadB, aacC1, aacC2, aacC3, aacA4, aac6'-IIa, ermA, ermB, ermC, mecA, vanA, vanB, vanC, satA, aac(6)-aph(2"), aad(6'), vat, vga, msrA, sul and int are also disclosed. The above microbial species, genera and resistance genes arc all clinically relevant and commonly encountered in a variety of clinical specimens. These DNA-based assays are rapid, accurate and can be used in clinical microbiology laboratories for routine diagnosis. These novel diagnostic tools should be useful to improve the speed and accuracy of diagnosis of microbial infections, thereby allowing more effective treatments. Diagnostic kits for (i) the universal detection and quantification of bacteria, and/or (ii) the detection, identification and quantification of the above-mentioned bacterial and fungal species and/or genera, and/or (iii) the detection, identification and quantification of the above-mentioned antibiotic resistance genes arc also claimed.

    摘要翻译： 基于DNA的方法用人扩增引物或探针，用于检测，鉴定，和选自（i）的任何细菌，在一个测试样品DNA定量（ii）所述种类无乳链球菌，腐生葡萄球菌，屎肠球菌，脑膜炎奈瑟氏菌，李斯特菌和白色念珠菌 ，和（iii）各属链球菌，葡萄球菌，肠球菌属，奈瑟氏球菌属和念珠菌的任何种类游离缺失光盘。 基于DNA的方法用人扩增引物或探针，用于检测，鉴定，并在选自BLA TEM中选择的测试样品的抗生素抗性基因定量，血乳酸抢劫，BLA SHV，血乳酸氧杂，blaZ，aadB，aacC1，aacC2，aacC3 ，aacA4，aac6'-IIA，ERMA，ermB，ERMC，mecA基因，VANA，vanB，VANC，SATA AAC（6）-aph（2“），AAD（6“），大桶，VGA，MSRA，SUL和INT 所以被盘游离缺失。上述的微生物物种，属和抗性基因电弧所有临床相关并在各种临床标本的通常遇到的，这些基于DNA的测定是快速，准确，并且可以在临床微生物学实验室进行常规诊断中使用。这些新的 诊断工具应该是提高速度和微生物感染，从而允许更有效的治疗的诊断的准确性是有用的。对于（i）所述通用检测和细菌的定量，和/或（ii）的检测，鉴定和定量的诊断试剂盒 上述细菌 和真菌种类和/或属，和/或（iii）检测，鉴定和上述抗生素抗性基因的定量弧这样声称。

    Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories
    2.
    发明公开
    Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories 失效
    物种特异性的，性别特异性通用DNA探针和扩增引物的快速检测和的常规细菌和抗真菌病原体和从临床样品相关的抗生素抗性基因在微生物实验室诊断标识

    公开(公告)号：EP2339034A1

    公开(公告)日：2011-06-29

    申请号：EP10181608.0

    申请日：1997-11-04

    申请人： Geneohm Sciences Canada, Inc.

    发明人： Bergeron, Michel G. ,  Picard, Francois ,  Ouellette, Marc ,  Roy, Paul H.

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/689 ,  C07K14/195 ,  C07K14/21 ,  C07K14/212 ,  C07K14/245 ,  C07K14/26 ,  C07K14/285 ,  C07K14/31 ,  C07K14/315 ,  C07K14/3156 ,  C12Q1/6895 ,  C12Q2600/156

    摘要： DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample DNA from (i) any bacterium, (ii) the species Streptococcus agalactiae, Staphylococcus saprophyticus, Enterococcus faecium, Neisseria meningitidis, Listeria monocytogenes and Candida albicans, and (iii) any species of the genera Streptococcus, Staphylococcus, Enterococcus, Neisseria and Candida are disclosed. DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample antibiotic resistance genes selected from the group consisting of bla tem , bla rob , bla shv , bla oxa , blaZ, aadB , aacC1, aacC2 , aacC3 , aacA4, aac6'-IIa , ermA, ermB, ermC, mecA, vanA, vanB, vanC, satA, aac(6')-aph(2"), aad(6') , vat, vga, msrA, sul and int are also disclosed. The above microbial species, genera and resistance genes arc all clinically relevant and commonly encountered in a variety of clinical specimens. These DNA-based assays are rapid, accurate and can be used in clinical microbiology laboratories for routine diagnosis. These novel diagnostic tools should be useful to improve the speed and accuracy of diagnosis of microbial infections, thereby allowing more effective treatments. Diagnostic kits for (i) the universal detection and quantification of bacteria, and/or (ii) the detection, identification and quantification of the above-mentioned bacterial and fungal species and/or genera, and/or (iii) the detection, identification and quantification of the above-mentioned antibiotic resistance genes arc also claimed.

    摘要翻译： 基于DNA的方法用人扩增引物或探针，用于检测，鉴定，和选自（i）的任何细菌，在一个测试样品DNA定量（ii）所述种类无乳链球菌，腐生葡萄球菌，屎肠球菌，脑膜炎奈瑟氏菌，李斯特菌和白色念珠菌 ，和（iii）各属链球菌，葡萄球菌，肠球菌属，奈瑟氏球菌属和念珠菌的任何种类游离缺失光盘。 基于DNA的方法用人扩增引物或探针，用于检测，鉴定，并在选自BLA TEM中选择的测试样品的抗生素抗性基因定量，血乳酸抢劫，BLA SHV，血乳酸氧杂，blaZ，aadB，aacC1，aacC2，aacC3 ，aacA4，aac6'-IIA，ERMA，ermB，ERMC，mecA基因，VANA，vanB，VANC，SATA，AAC（6“） - APH（2“），AAD（6' ），大桶，VGA，MSRA，SUL和 所以INT被光盘游离缺失。上述的微生物物种，属和抗性基因弧所有临床相关并在各种临床标本的通常遇到的，这些基于DNA的测定是快速，准确，并且可以在临床微生物学实验室进行常规诊断中使用。这些 新的诊断工具应该是提高速度和微生物感染，从而允许更有效的治疗的诊断的准确性是有用的。对于（i）所述通用检测和细菌的定量，和/或（ii）检测，鉴定和定量的诊断试剂盒 上述BAC的 TERIAL和真菌种类和/或属，和/或（iii）检测，鉴定和上述抗生素抗性基因的定量弧这样声称。

    Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories
    5.
    发明公开
    Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories 失效
    假丝酵母假丝酵母菌Nukleinsäuresequenzzur Identifizierung und Erkennung in klinischen Proben

    公开(公告)号：EP2336364A1

    公开(公告)日：2011-06-22

    申请号：EP10181610.6

    申请日：1997-11-04

    申请人： Geneohm Sciences Canada, Inc.

    发明人： Bergeron, Michel G. ,  Picard, Francois ,  Ouellette, Marc ,  Roy, Paul H.

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/689 ,  C07K14/195 ,  C07K14/21 ,  C07K14/212 ,  C07K14/245 ,  C07K14/26 ,  C07K14/285 ,  C07K14/31 ,  C07K14/315 ,  C07K14/3156 ,  C12Q1/6895 ,  C12Q2600/156

    摘要： DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample DNA from (i) any bacterium, (ii) the species Streptococcus agalactiae, Staphylococcus saprophyticus, Enterococcus faecium, Neisseria meningitidis, Listeria monocytogenes and Candida albicans, and (iii) any species of the genera Streptococcus, Staphylococcus, Enterococcus, Neisseria and Candida are disclosed. DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample antibiotic resistance genes selected from the group consisting of bla tem , bla rob , bla shv , bla oxa , blaZ, aadB, aacC1, aacC2 , aacC3 , aacA4, aac6'-lla , ermA, ermB, ermC, mecA, vanA, vanB, vanC, satA, aac(6)-aph(2"), aad(6' ), vat, vga, msrA, sul and int are also disclosed. The above microbial species, genera and resistance genes arc all clinically relevant and commonly encountered in a variety of clinical specimens. These DNA-based assays are rapid, accurate and can be used in clinical microbiology laboratories for routine diagnosis. These novel diagnostic tools should be useful to improve the speed and accuracy of diagnosis of microbial infections, thereby allowing more effective treatments. Diagnostic kits for (i) the universal detection and quantification of bacteria, and/or (ii) the detection, identification and quantification of the above-mentioned bacterial and fungal species and/or genera, and/or (iii) the detection, identification and quantification of the above-mentioned antibiotic resistance genes arc also claimed.

    摘要翻译： 基于DNA的方法，使用扩增引物或探针来检测，鉴定和定量来自（i）任何细菌的测试样品DNA，（ii）无乳链球菌，腐生葡萄球菌，屎肠球菌，脑膜炎奈瑟氏球菌，单核细胞增生利斯特氏菌和白色念珠菌 ，和（iii）任何种属的链球菌属，葡萄球菌属，肠球菌属，奈瑟球菌属和假丝酵母属。 基于DNA的方法，使用扩增引物或探针来检测，鉴定和定量测试样品抗生素抗性基因，其选自bla tem，bla rob，bla shv，bla oxa，blaZ，aadB，aacC1，aacC2，aacC3 ，aacA4，aac6'-11a，ermA，ermB，ermC，mecA，vanA，vanB，vanC，satA，aac（6）-aph（2“），aad（6'），vat，vga，msrA，sul和int 上述微生物物种，属和抗性基因全部临床相关，常见于各种临床标本，这些基于DNA的检测方法快速，准确，可用于临床微生物实验室进行常规诊断。 诊断工具应有助于提高微生物感染诊断的速度和准确性，从而允许更有效的治疗。诊断试剂盒用于（i）细菌的普遍检测和定量，和/或（ii）检测，鉴定和定量 上面提到的细菌 和/或（iii）上述抗生素抗性基因的检测，鉴定和定量也被要求保护。

    Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories
    6.
    发明公开
    Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories 失效
    Enteroccocus属特异性探针和扩增引物对临床标本的快速检测和鉴定

    公开(公告)号：EP2339033A1

    公开(公告)日：2011-06-29

    申请号：EP10181601.5

    申请日：1997-11-04

    申请人： Geneohm Sciences Canada, Inc.

    发明人： Bergeron, Michel G. ,  Picard, Francois ,  Ouellette, Marc ,  Roy, Paul H.

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/689 ,  C07K14/195 ,  C07K14/21 ,  C07K14/212 ,  C07K14/245 ,  C07K14/26 ,  C07K14/285 ,  C07K14/31 ,  C07K14/315 ,  C07K14/3156 ,  C12Q1/6895 ,  C12Q2600/156

    摘要： DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample DNA from (i) any bacterium, (ii) the species Streptococcus agalactiae, Staphylococcus saprophyticus, Enterococcus faecium, Neisseria meningitidis, Listeria monocytogenes and Candida albicans, and (iii) any species of the genera Streptococcus, Staphylococcus, Enterococcus, Neisseria and Candida are disclosed. DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample antibiotic resistance genes selected from the group consisting of bla tem , bla rob , bla shv , bla oxa , blaZ, aadB , aacC1, aacC2, aacC3, aacA4, aac6'-Ila , ermA, ermB, ermC, mecA, vanA, vanB, vanC, satA, aac(6)-aph(2''), aad(6') , vat, vga, msrA, sul and int are also disclosed. The above microbial species, genera and resistance genes arc all clinically relevant and commonly encountered in a variety of clinical specimens. These DNA-based assays are rapid, accurate and can be used in clinical microbiology laboratories for routine diagnosis. These novel diagnostic tools should be useful to improve the speed and accuracy of diagnosis of microbial infections, thereby allowing more effective treatments. Diagnostic kits for (i) the universal detection and quantification of bacteria, and/or (ii) the detection, identification and quantification of the above-mentioned bacterial and fungal species and/or genera, and/or (iii) the detection, identification and quantification of the above-mentioned antibiotic resistance genes arc also claimed.

    摘要翻译： 基于DNA的方法用人扩增引物或探针，用于检测，鉴定，和选自（i）的任何细菌，在一个测试样品DNA定量（ii）所述种类无乳链球菌，腐生葡萄球菌，屎肠球菌，脑膜炎奈瑟氏菌，李斯特菌和白色念珠菌 ，和（iii）各属链球菌，葡萄球菌，肠球菌属，奈瑟氏球菌属和念珠菌的任何种类游离缺失光盘。 基于DNA的方法用人扩增引物或探针，用于检测，鉴定，并在选自BLA TEM中选择的测试样品的抗生素抗性基因定量，血乳酸抢劫，BLA SHV，血乳酸氧杂，blaZ，aadB，aacC1，aacC2，aacC3 ，aacA4，aac6'-IIA，ERMA，ermB，ERMC，mecA基因，VANA，vanB，VANC，SATA AAC（6）-aph（2 ''），AAD（6“），大桶，VGA，MSRA，SUL和 所以INT是游离缺失盘。 以上微生物物种，属和抗性基因弧的所有临床相关并在各种临床标本中经常遇到的。 这些基于DNA的测定是快速，准确，并且可以在临床微生物学实验室进行常规诊断中使用。 这些新颖的诊断工具应该是提高速度和微生物感染的诊断精度，从而允许更有效的治疗是有用的。 为（i）所述通用检测和细菌的定量，和/或（ii）的检测，鉴定和上述细菌和真菌物种和/或属的定量，和/或（iii）检测，鉴定诊断试剂盒 和上述的抗生素抗性基因的定量弧这样声称。

    Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories
    7.
    发明公开
    Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories 失效
    李斯特菌特异性DNA探针和扩增引物对临床标本的快速检测和鉴定

    公开(公告)号：EP2336365A1

    公开(公告)日：2011-06-22

    申请号：EP10181604.9

    申请日：1997-11-04

    申请人： Geneohm Sciences Canada, Inc.

    发明人： Bergeron, Michel G. ,  Picard, Francois ,  Ouellette, Marc ,  Roy, Paul H.

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/689 ,  C07K14/195 ,  C07K14/21 ,  C07K14/212 ,  C07K14/245 ,  C07K14/26 ,  C07K14/285 ,  C07K14/31 ,  C07K14/315 ,  C07K14/3156 ,  C12Q1/6895 ,  C12Q2600/156

    摘要： DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample DNA from (i) any bacterium, (ii) the species Streptococcus agalactiae, Staphylococcus saprophyticus, Enterococcus faecium, Neisseria meningitidis, Listeria monocytogenes and Candida albicans, and (iii) any species of the genera Streptococcus, Staphylococcus, Enterococcus, Neisseria and Candida are disclosed. DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample antibiotic resistance genes selected from the group consisting of bla tem , bla rob , bla shv , bla oxa , blaZ, aadB, aacC1, aacC2, aacC3, aacA4, aac6' -//a, ermA, ermB, ermC, mecA, vanA, vanB, vanC, satA, aac(6')-aph(2'), aad(6), vat, vga, msrA, sul and int are also disclosed. The above microbial species, genera and resistance genes arc all clinically relevant and commonly encountered in a variety of clinical specimens. These DNA-based assays are rapid, accurate and can be used in clinical microbiology laboratories for routine diagnosis. These novel diagnostic tools should be useful to improve the speed and accuracy of diagnosis of microbial infections, thereby allowing more effective treatments. Diagnostic kits for (i) the universal detection and quantification of bacteria, and/or (ii) the detection, identification and quantification of the above-mentioned bacterial and fungal species and/or genera, and/or (iii) the detection, identification and quantification of the above-mentioned antibiotic resistance genes arc also claimed.

    摘要翻译： 基于DNA的方法用人扩增引物或探针，用于检测，鉴定，和选自（i）的任何细菌，在一个测试样品DNA定量（ii）所述种类无乳链球菌，腐生葡萄球菌，屎肠球菌，脑膜炎奈瑟氏菌，李斯特菌和白色念珠菌 ，和（iii）各属链球菌，葡萄球菌，肠球菌属，奈瑟氏球菌属和念珠菌的任何种类游离缺失光盘。 基于DNA的方法用人扩增引物或探针，用于检测，鉴定，并在选自BLA TEM中选择的测试样品的抗生素抗性基因定量，血乳酸抢劫，BLA SHV，血乳酸氧杂，blaZ，aadB，aacC1，aacC2，aacC3 ，aacA4，aac6 ' - //一个，ERMA，ermB，ERMC，mecA基因，VANA，vanB，VANC，SATA，AAC（6'） - APH（2“），AAD（6），还原，VGA，MSRA，SUL 所以INT的游离缺失盘。 以上微生物物种，属和抗性基因弧的所有临床相关并在各种临床标本中经常遇到的。 这些基于DNA的测定是快速，准确，并且可以在临床微生物学实验室进行常规诊断中使用。 这些新颖的诊断工具应该是提高速度和微生物感染的诊断精度，从而允许更有效的治疗是有用的。 为（i）所述通用检测和细菌的定量，和/或（ii）的检测，鉴定和上述细菌和真菌物种和/或属的定量，和/或（iii）检测，鉴定诊断试剂盒 和上述的抗生素抗性基因的定量弧这样声称。