公开(公告)号：EP1678327A2

公开(公告)日：2006-07-12

申请号：EP04794735.3

申请日：2004-10-11

申请人： Genomic Health, Inc.

发明人： BAKER, Joffre, B. ,  CRONIN, Maureen, T. ,  KIEFER, Michael, C. ,  LI, Xitong ,  CLARK, Kim

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C12Q1/6806 ,  C12Q2561/101 ,  C12Q2537/143

摘要： The invention concerns an integrated, qRT-PCR-based system for analyzing and reporting RNA expression profiles of biological samples. In particular, the invention concerns a fully optimized and integrated multiplex, multi-analyte method for expression profiling of RNA in biological samples, including fixed, paraffin-embedded tissue samples. The gene expression profiles obtained can be used for the clinical diagnosis, classification and prognosis of various pathological conditions, including cancer.

公开(公告)号：EP1488007A1

公开(公告)日：2004-12-22

申请号：EP03744665.5

申请日：2003-03-12

申请人： Genomic Health, Inc.

发明人： BAKER, Joffre, B. ,  CRONIN, Maureen, T. ,  KIEFER, Michael, C. ,  SHAK, Steve ,  WALKER, Michael, G.

IPC分类号： C12Q1/68 ,  G01N33/53

CPC分类号： G01N33/57484 ,  C12N15/1003 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57415

摘要： The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.

公开(公告)号：EP2598659B1

公开(公告)日：2015-03-11

申请号：EP11813024.4

申请日：2011-07-25

申请人： Genomic Health, Inc.

发明人： SHAK, Steven ,  BAEHNER, Frederick, L. ,  MADDALA, Tara ,  LEE, Mark ,  PELHAM, Robert, J. ,  COWENS, Wayne ,  CHERBAVAZ, Diana ,  KIEFER, Michael, C. ,  CRAGER, Michael ,  GODDARD, Audrey ,  BAKER, Joffre, B.

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178 ,  G06F19/00

摘要： Molecular assays that involve measurement of expression levels of prognostic biomarkers, or co-expressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis of the measured expression levels to provide information concerning the likely prognosis for said patient, and likelihood that said patient will have a recurrence of prostate cancer, or to classify the tumor by likelihood of clinical outcome or TMPRSS2 fusion status, are provided herein.

公开(公告)号：EP1974058A2

公开(公告)日：2008-10-01

申请号：EP07717900.0

申请日：2007-01-11

申请人： Genomic Health, Inc. ,  NSABP Foundation, Inc.

发明人： COWENS, Wayne ,  BAKER, Joffre, B. ,  CLARK, Kim ,  HACKETT, James ,  WATSON, Drew ,  PAIK, Soonmyung

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  G01N33/57419 ,  G01N33/57446

摘要： A method of predicting clinical outcome for a human subject diagnosed with colorectal cancer following surgical resection of said cancer is disclosed. A normalized expression level is determined of an RNA transcript of MYBL2, or an expression product thereof, in a biological sample comprising cancer cells obtained from said human subject. The likelihood of a positive clinical outcome for said human subject is then predicted based on said normalized expression level, wherein normalized expression of an RNA transcript of MYBL2, or an expression product thereof, is positively correlated with an increased likelihood of a positive clinical outcome.

公开(公告)号：EP2598659A2

公开(公告)日：2013-06-05

申请号：EP11813024.4

申请日：2011-07-25

申请人： Genomic Health, Inc.

发明人： SHAK, Steven ,  BAEHNER, Frederick, L. ,  MADDALA, Tara ,  LEE, Mark ,  PELHAM, Robert, J. ,  COWENS, Wayne ,  CHERBAVAZ, Diana ,  KIEFER, Michael, C. ,  CRAGER, Michael ,  GODDARD, Audrey ,  BAKER, Joffre, B.

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178 ,  G06F19/00

摘要： Molecular assays that involve measurement of expression levels of prognostic biomarkers, or co-expressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis of the measured expression levels to provide information concerning the likely prognosis for said patient, and likelihood that said patient will have a recurrence of prostate cancer, or to classify the tumor by likelihood of clinical outcome or TMPRSS2 fusion status, are provided herein.

公开(公告)号：EP2294215B1

公开(公告)日：2013-01-16

申请号：EP09747388.8

申请日：2009-05-12

申请人： Genomic Health, Inc. ,  Aventis Inc.

发明人： SHAK, Steve ,  BAKER, Joffre, B. ,  YOSHIZAWA, Carl ,  SPARANO, Joseph ,  GRAY, Robert

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/574 ,  G01N33/57415 ,  G01N2333/705 ,  G01N2333/72 ,  G01N2800/52 ,  G01N2800/60

公开(公告)号：EP1631689A2

公开(公告)日：2006-03-08

申请号：EP04776118.4

申请日：2004-05-24

申请人： Genomic Health, Inc.

发明人： BAKER, Joffre, B. ,  MILLER, Kathy, D. ,  SHAK, Steven ,  SLEDGE, George, W. ,  SOULE, Sharon, E. Indiana Univ. School of Medicine

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q1/6837 ,  C12Q2600/106 ,  C12Q2600/158

摘要： The invention provides sets of genes the expression of which predicts whether cancer patients are likely to have a beneficial treatment response to chemotherapy.

公开(公告)号：EP1570080A1

公开(公告)日：2005-09-07

申请号：EP03786796.7

申请日：2003-11-14

申请人： Genomic Health, Inc. ,  Vall d'Hebron University Hospital

发明人： BAKER, Joffre, B. ,  CRONIN, Maureen, T. ,  SHAK, Steven ,  BASELGA, Jose

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  C12Q2600/16

摘要： The present invention concerns prognostic markers associated with EGFR positive cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin-embedded, fixed tissue samples of EGFRexpressing cancer, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR inhibitor.

公开(公告)号：EP1974058B1

公开(公告)日：2014-06-11

申请号：EP07717900.0

申请日：2007-01-11

申请人： Genomic Health, Inc. ,  NSABP Foundation, Inc.

发明人： COWENS, Wayne ,  BAKER, Joffre, B. ,  CLARK, Kim ,  HACKETT, James ,  WATSON, Drew ,  PAIK, Soonmyung

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  G01N33/57419 ,  G01N33/57446

公开(公告)号：EP1815014B1

公开(公告)日：2012-03-21

申请号：EP05821698.7

申请日：2005-11-04

申请人： Genomic Health, Inc. ,  NSABP Foundation, Inc.

发明人： BAKER, Joffre, B. ,  BRYANT, John, L. ,  PAIK, Soonmyung ,  SHAK, Steven

IPC分类号： C12Q1/68 ,  G01N33/574 ,  C12N15/10

CPC分类号： G01N33/57415 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  G06F19/18 ,  G06F19/20

摘要： The present invention relates to quantitative molecular indicators that can guide clinical decisions in breast cancer, such as estrogen receptor (ESR1)-positive, lymph node-negative breast cancer. In particular, the invention concerns certain genes, the varied expression of which indicates the likelihood of recurrence of surgically resected breast cancer in patients who are not treated with a therapeutic agent in the adjuvant setting. In addition, the invention concerns the use of quantitative measurement of the expression of certain genes, including the ESR1 gene, that measures as a continuous variable, to determine (a) the likelihood of a beneficial response to the anti-estrogen therapeutic agent, such as tamoxifen; and (b) the potential magnitude of beneficial response to chemotheraphy.