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1.发明公开GENE EXPRESSION MARKERS FOR PREDICTING RESPONSE TO CHEMOTHERAPY 有权基因表达标记ZUR VORHERSAGE DER REAKING AUF CHEMOTHERAPIE
公开(公告)号：EP2947160A1
公开(公告)日：2015-11-25
申请号：EP15173816.8
申请日：2005-04-07
发明人： Baker, Joffre , Shak, Steven , Gianni, Luca
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , Y10S435/96
摘要： The present invention provides sets of genes the expression of which is important in the prognosis of cancer. In particular, the invention provides gene expression information useful for predicting whether cancer patients are likely to have a beneficial treatment response to chemotherapy.
摘要翻译： 本发明提供了一组基因，其表达在癌症的预后中是重要的。 特别地，本发明提供了可用于预测癌症患者是否可能对化学疗法有有益治疗反应的基因表达信息。
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2.发明授权Tests to predict responsiveness of cancer patients to chemotherapy treatment options 有权预测癌症患者对化疗治疗选择的反应性的测试
公开(公告)号：EP2607497B1
公开(公告)日：2014-10-01
申请号：EP13159677.7
申请日：2009-05-12
发明人： Shak, Steve , Baker, Joffre , Yoshizawa, Carl , Gray, Robert , Sparano, Joseph
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/574 , G01N33/57415 , G01N2333/705 , G01N2333/72 , G01N2800/52 , G01N2800/60
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3.发明公开Prediction of likelihood of cancer recurrence 有权Vorhersage der Wahrscheinlichkeit eines Wiederauftretens von Krebs
公开(公告)号：EP2775000A1
公开(公告)日：2014-09-10
申请号：EP14163233.1
申请日：2004-06-17
发明人： Baker, Joffre , Bryant, John L. , Paik, Soonmyung , Shak, Steve
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of cancer, in particular of breast cancer.
摘要翻译： 本发明提供了基因组，其表达在癌症，特别是乳腺癌的诊断和/或预后中是重要的。
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公开(公告)号：EP2412820A1
公开(公告)日：2012-02-01
申请号：EP10194713.3
申请日：2007-01-11
发明人： Cowens, Wayne , Hackett, James , Watson, Drew , Paik, Soonmyung , Clark, Kim , Baker, Joffre
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , G01N33/57419 , G01N33/57446
摘要： A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of an RNA transcript of FAP or an expression product thereof in a biological sample of cancer cells obtained from the subject.
摘要翻译： 预测诊断患有结肠直肠癌的受试者的临床结果的方法，包括确定从受试者获得的癌细胞的生物样品中FAP的RNA转录物或其表达产物的表达的证据。
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5.发明授权
公开(公告)号：EP2913405B1
公开(公告)日：2016-11-09
申请号：EP15152517.7
申请日：2011-07-25
申请人： Genomic Health, Inc.
发明人： Shak, Steve , Baehner, Frederick L. , Maddala, Tara , Lee, Mark , Pelham, Robert J. , Cowens, Wayne , Cherbavaz, Diana , Kiefer, Michael C. , Crager, Michael , Goddard, Audrey , Baker, Joffre
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178 , G06F19/00
摘要： Molecular assays that involve measurement of expression levels of prognostic biomarkers, or co-expressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis of the measured expression levels to provide information concerning the likely prognosis for said patient, and likelihood that said patient will have a recurrence of prostate cancer, or to classify the tumor by likelihood of clinical outcome or TMPRSS2 fusion status, are provided herein.
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6.发明授权Tests to predict responsiveness of cancer patients to chemotherapy treatment options 有权测试预测癌症患者的化疗治疗方案的响应
公开(公告)号：EP2568053B1
公开(公告)日：2014-04-16
申请号：EP12195318.6
申请日：2009-05-12
申请人： Genomic Health, Inc. , Aventis Inc.
发明人： Shak, Steve , Baker, Joffre , Yoshizawa, Carl , Sparano, Joseph , Gray, Robert
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/574 , G01N33/57415 , G01N2333/705 , G01N2333/72 , G01N2800/52 , G01N2800/60
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公开(公告)号：EP2412823A1
公开(公告)日：2012-02-01
申请号：EP10194719.0
申请日：2007-01-11
发明人： Cowens, Wayne , Baker, Joffre , Hackett, James , Watson, Drew , Paik, Soonmyung , Clark, Kim
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , G01N33/57419 , G01N33/57446
摘要： A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of an RNA transcript of EFNB2 or an expression product thereof in a biological sample of cancer cells obtained from the subject.
摘要翻译： 预测诊断为结肠直肠癌的受试者的临床结果的方法，包括确定从受试者获得的癌细胞的生物样品中EFNB2的RNA转录物或其表达产物的表达的证据。
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8.发明公开Gene expression markers for colorectal cancer prognosis 有权AREG als Genexpressionsmarker zur Kolorektalkrebsprognose
公开(公告)号：EP2412821A1
公开(公告)日：2012-02-01
申请号：EP10194714.1
申请日：2007-01-11
发明人： Cowens, Wayne , Baker, Joffre , Hackett, James , Watson, Drew , Paik, Soonmyung , Clark, Kim
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , G01N33/57419 , G01N33/57446
摘要： A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of an RNA transcript of AREG or its expression product in a biological sample of cancer cells obtained from the subject.
摘要翻译： 一种预测诊断为结肠直肠癌的受试者的临床结果的方法，包括确定从受试者获得的癌细胞的生物样品中AREG或其表达产物的RNA转录物的表达的证据。
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公开(公告)号：EP3170906B1
公开(公告)日：2018-08-22
申请号：EP16196459.8
申请日：2004-06-17
发明人： Baker, Joffre , Shak, Steve , Bryant, John , Paik, Soonmyung
IPC分类号： C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of cancer, in particular of breast cancer.
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公开(公告)号：EP3170906A1
公开(公告)日：2017-05-24
申请号：EP16196459.8
申请日：2004-06-17
发明人： Baker, Joffre , Shak, Steve , Bryant, John , Paik, Soonmyung
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of cancer, in particular of breast cancer.
摘要翻译： 本发明提供了基因组，其表达在癌症，特别是乳腺癌的诊断和/或预后中是重要的。
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