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公开(公告)号：EP3309157B1
公开(公告)日：2019-09-04
申请号：EP17190692.8
申请日：2010-05-12
发明人： GUO, Hongyan , KATO, Darryl , KIRSCHBERG, Thorstens A. , LIU, Hongtae , LINK, John O. , MITCHELL, Michael L. , PARRISH, Jay P. , SQUIRES, Neil , SUN, Jianyu , TAYLOR, James , BACON, Elizabeth M. , CANALES, Eda , CHO, Aesop , COTTELL, Jeromy J. , DESAI, Manoj C. , HALCOMB, Randall L. , KRYGOWSKI, Evan S. , LAZERWITH, Scott E. , LIU, Qi , MACKMAN, Richard , PYUN, Hyung-Jung , SAUGIER, Joseph H. , TRENKLE, James D. , TSE, Winston C. , VIVIAN, Randall W. , SCHROEDER, Scott D. , WATKINS, William J. , XU, Lianhong , YANG, Zheng-Yu , KELLAR, Terry , SHENG, Xiaoning , CLARKE, Michael O'Neil Hanrahan , CHOU, Chien-hung , GRAUPE, Michael , JIN, Haolun , MCFADDEN, Ryan , MISH, Michael R. , METOBO, Samuel E. , PHILLIPS, Barton W. , VENKATARAMANI, Chandrasekar , KIM, Chuong U.
IPC分类号： C07D409/14 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D207/16 , C07D495/04 , A61K31/12 , A61P31/12 , A61K45/06 , A61K31/4025 , A61K31/4178 , A61K31/4184 , C07F5/02 , A61K31/427
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公开(公告)号：EP3309157A1
公开(公告)日：2018-04-18
申请号：EP17190692.8
申请日：2010-05-12
发明人： GUO, Hongyan , KATO, Darryl , KIRSCHBERG, Thorstens A. , LIU, Hongtae , LINK, John O. , MITCHELL, Michael L. , PARRISH, Jay P. , SQUIRES, Neil , SUN, Jianyu , TAYLOR, James , BACON, Elizabeth M. , CANALES, Eda , CHO, Aesop , COTTELL, Jeromy J. , DESAI, Manoj C. , HALCOMB, Randall L. , KRYGOWSKI, Evan S. , LAZERWITH, Scott E. , LIU, Qi , MACKMAN, Richard , PYUN, Hyung-Jung , SAUGIER, Joseph H. , TRENKLE, James D. , TSE, Winston C. , VIVIAN, Randall W. , SCHROEDER, Scott D. , WATKINS, William J. , XU, Lianhong , YANG, Zheng-Yu , KELLAR, Terry , SHENG, Xiaoning , CLARKE, Michael O'Neil Hanrahan , CHOU, Chien-hung , GRAUPE, Michael , JIN, Haolun , MCFADDEN, Ryan , MISH, Michael R. , METOBO, Samuel E. , PHILLIPS, Barton W. , VENKATARAMANI, Chandrasekar , KIM, Chuong U.
IPC分类号： C07D409/14 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D207/16 , C07D495/04 , A61K31/12 , A61P31/12
CPC分类号： C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：EP3002281B1
公开(公告)日：2017-09-13
申请号：EP15180635.3
申请日：2010-05-12
发明人： GUO, Hongyan , KATO, Darryl , KIRSCHBERG, Thorstens A. , LIU, Hongtae , LINK, John O. , MITCHELL, Michael L. , PARRISH, Jay P. , SQUIRES, Neil , SUN, Jianyu , TAYLOR, James , BACON, Elizabeth M. , CANALES, Eda , CHO, Aesop , COTTELL, Jeromy J. , DESAI, Manoj C. , HALCOMB, Randall L. , KRYGOWSKI, Evan S. , LAZERWITH, Scott E. , LIU, Qi , MACKMAN, Richard , PYUN, Hyung-Jung , SAUGIER, Joseph H. , TRENKLE, James D. , TSE, Winston C. , VIVIAN, Randall W. , SCHROEDER, Scott D. , WATKINS, William J. , XU, Lianhong , YANG, Zheng-Yu , KELLAR, Terry , SHENG, Xiaoning , CLARKE, Michael O'Neil Hanrahan , CHOU, Chien-hung , GRAUPE, Michael , JIN, Haolun , McFADDEN, Ryan , MISH, Michael R. , METOBO, Samuel E. , PHILLIPS, Barton W. , VENKATARAMANI, Chandrasekar , KIM, Chuong U.
IPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/14 , C07D495/04 , A61K31/4184 , A61K45/06 , C07D471/08 , C07F5/02 , C07D413/14 , A61K31/4025 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/113 , C07D207/16 , A61K31/4188 , A61K31/4178 , A61P31/12
CPC分类号： C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明提供了药物组合物，其包含：（1）下式的化合物或其药学上可接受的盐; （2）NS5B聚合酶抑制剂; 和（3）NS3蛋白酶抑制剂; （1），（2）和（3）的组合在预防或治疗丙型肝炎或丙型肝炎相关疾病中的用途。
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公开(公告)号：EP3002281A1
公开(公告)日：2016-04-06
申请号：EP15180635.3
申请日：2010-05-12
发明人： GUO, Hongyan , KATO, Darryl , KIRSCHBERG, Thorstens A. , LIU, Hongtae , LINK, John O. , MITCHELL, Michael L. , PARRISH, Jay P. , SQUIRES, Neil , SUN, Jianyu , TAYLOR, James , BACON, Elizabeth M. , CANALES, Eda , CHO, Aesop , COTTELL, Jeromy J. , DESAI, Manoj C. , HALCOMB, Randall L. , KRYGOWSKI, Evan S. , LAZERWITH, Scott E. , LIU, Qi , MACKMAN, Richard , PYUN, Hyung-Jung , SAUGIER, Joseph H. , TRENKLE, James D. , TSE, Winston C. , VIVIAN, Randall W. , SCHROEDER, Scott D. , WATKINS, William J. , XU, Lianhong , YANG, Zheng-Yu , KELLAR, Terry , SHENG, Xiaoning , CLARKE, Michael O'Neil Hanrahan , CHOU, Chien-hung , GRAUPE, Michael , JIN, Haolun , McFADDEN, Ryan , MISH, Michael R. , METOBO, Samuel E. , PHILLIPS, Barton W. , VENKATARAMANI, Chandrasekar , KIM, Chuong U.
IPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/14 , C07D495/04 , A61K31/4184 , A61K45/06 , C07D471/08 , C07F5/02 , A61K31/4188 , A61K31/4178 , A61P31/12
CPC分类号： C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025
摘要： The invention is related to anti-viral compounds of formula
compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.摘要翻译： 本发明涉及含有这些化合物的式组合物的抗病毒化合物，以及包括给予这些化合物的治疗方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：EP3626716A1
公开(公告)日：2020-03-25
申请号：EP19193481.9
申请日：2010-05-12
发明人： GUO, Hongyan , KATO, Darryl , KIRSCHBERG, Thorstens A. , LIU, Hongtae , LINK, John O. , MITCHELL, Michael L. , PARRISH, Jay P. , SQUIRES, Neil , SUN, Jianyu , TAYLOR, James , BACON, Elizabeth , CANALES, Eda , CHO, Aesop , COTTELL, Jeromy J. , DESAI, Manoj C. , HALCOMB, Randall L. , KRYGOWSKI, Evan S. , LAZERWITH, Scott E. , LIU, Qi , MACKMAN, Richard , PYUN, Hyung-Jung , SAUGIER, Joseph H. , TRENKLE, James D. , TSE, Winston C. , VIVIAN, Randall W. , SCHROEDER, Scott D. , WATKINS, William J. , XU, Lianhong , YANG, Zheng-Yu , KELLAR, Terry , SHENG, Xiaoning , CLARKE, Michael O'Neil Hanrahan , CHOU, Chien-hung , GRAUPE, Michael , JIN, Haolun , MCFADDEN, Ryan , MISH, Michael R. , METOBO, Samuel E. , PHILLIPS, Barton W. , VENKATARAMANI, Chandrasekar , KIM, Chuong U.
IPC分类号： C07D409/14 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D207/16 , C07D495/04 , A61K31/12 , A61P31/12
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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