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公开(公告)号：EP3284741A1
公开(公告)日：2018-02-21
申请号：EP17169675.0
申请日：2011-11-16
发明人： BACON, Elizabeth M. , COTTELL, Jeromy J. , KATANA, Ashley Anne , KATO, Darryl , KRYGOWSKI, Evan S. , LINK, John O. , TAYLOR, James , TRAN, Chinh Viet , TREJO MARTIN, Teresa Alejandra , YANG, Zheng-Yu , ZIPFEL, Sheila
IPC分类号： C07D403/14 , C07D405/14 , C07D417/14 , C07D471/08 , C07D491/10 , C07D493/04 , C07D495/04 , C07D513/04 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61P31/12 , A61K45/06
CPC分类号： C07D403/14 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61K31/5377 , A61K45/06 , C07D405/14 , C07D417/14 , C07D471/08 , C07D491/10 , C07D491/107 , C07D491/113 , C07D493/04 , C07D495/04 , C07D513/04 , A61K2300/00
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及抗病毒化合物，含有这些化合物的组合物，以及包括给予这些化合物的治疗方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：EP3778606A3
公开(公告)日：2021-03-03
申请号：EP20194823.9
申请日：2012-11-16
发明人： BACON, Elizabeth , COTTELL, Jeromy , KATANA, Ashley Anne , KATO, Darryl , KRYGOWSKI, Evan , LINK, John , TAYLOR, James , TRAN, Chinh Viet , MARTIN, Teresa Alejandra Trejo , YANG, Zheng-Yu , ZIPFEL, Sheila
IPC分类号： C07D491/052 , A61K31/4188
摘要： The disclosure is related to intermediate compounds useful for preparing anti-viral compounds, and to methods for making intermediate compounds and anti-viral compounds.
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公开(公告)号：EP3626716A1
公开(公告)日：2020-03-25
申请号：EP19193481.9
申请日：2010-05-12
发明人： GUO, Hongyan , KATO, Darryl , KIRSCHBERG, Thorstens A. , LIU, Hongtae , LINK, John O. , MITCHELL, Michael L. , PARRISH, Jay P. , SQUIRES, Neil , SUN, Jianyu , TAYLOR, James , BACON, Elizabeth , CANALES, Eda , CHO, Aesop , COTTELL, Jeromy J. , DESAI, Manoj C. , HALCOMB, Randall L. , KRYGOWSKI, Evan S. , LAZERWITH, Scott E. , LIU, Qi , MACKMAN, Richard , PYUN, Hyung-Jung , SAUGIER, Joseph H. , TRENKLE, James D. , TSE, Winston C. , VIVIAN, Randall W. , SCHROEDER, Scott D. , WATKINS, William J. , XU, Lianhong , YANG, Zheng-Yu , KELLAR, Terry , SHENG, Xiaoning , CLARKE, Michael O'Neil Hanrahan , CHOU, Chien-hung , GRAUPE, Michael , JIN, Haolun , MCFADDEN, Ryan , MISH, Michael R. , METOBO, Samuel E. , PHILLIPS, Barton W. , VENKATARAMANI, Chandrasekar , KIM, Chuong U.
IPC分类号： C07D409/14 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D207/16 , C07D495/04 , A61K31/12 , A61P31/12
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：EP2430014B1
公开(公告)日：2015-08-19
申请号：EP10720970.2
申请日：2010-05-12
发明人： GUO, Hongyan , KATO, Darryl , KIRSCHBERG, Thorstens A. , LIU, Hongtae , LINK, John O. , MITCHELL, Michael L. , PARRISH, Jay P. , SQUIRES, Neil , SUN, Jianyu , TAYLOR, James , BACON, Elizabeth M. , CANALES, Eda , CHO, Aesop , COTTELL, Jeromy J. , DESAI, Manoj C. , HALCOMB, Randall L. , KRYGOWSKI, Evan S. , LAZERWITH, Scott E. , LIU, Qi , MACKMAN, Richard , PYUN, Hyung-Jung , SAUGIER; Joseph H. , TRENKLE, James D. , TSE, Winston C. , VIVIAN, RAndall W. , SCHROEDER; Scott D. , WATKINS, William J. , XU, Lianhong , YANG, Zheng-Yu , KELLAR, Terry , SHENG, Xiaoning , CLARKE; Michael O'Neil Hanrahan , CHOU, Chien-hung , GRAUPE, Michael , JIN, Haolun , MCFADDEN, Ryan , MISH, Michael R. , METOBO, Samuel E. , PHILLIPS, Barton W. , VENKATARAMANI, Chandrasekar , KIM, Chuong U.
IPC分类号： C07D401/14 , A61K31/4188 , A61P31/12
CPC分类号： C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：EP3778606A2
公开(公告)日：2021-02-17
申请号：EP20194823.9
申请日：2012-11-16
发明人： BACON, Elizabeth , COTTELL, Jeromy , KATANA, Ashley Anne , KATO, Darryl , KRYGOWSKI, Evan , LINK, John , TAYLOR, James , TRAN, Chinh Viet , MARTIN, Teresa Alejandra Trejo , YANG, Zheng-Yu , ZIPFEL, Sheila
IPC分类号： C07D491/052 , A61K31/4188
摘要： The disclosure is related to intermediate compounds useful for preparing anti-viral compounds, and to methods for making intermediate compounds and anti-viral compounds.
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公开(公告)号：EP3699176A3
公开(公告)日：2020-11-18
申请号：EP19215845.9
申请日：2011-11-16
发明人： BACON, Elizabeth M. , COTTELL, Jeromy J. , KATANA, Ashley Anne , KATO, Darryl , KRYGOWSKI, Evan S. , LINK, John O. , TAYLOR, James , TRAN, Chinh Viet , TREJO MARTIN, Teresa Alejandra , YANG, Zheng-Yu , ZIPFEL, Sheila
IPC分类号： C07D403/14 , C07D405/14 , C07D417/14 , C07D471/08 , C07D491/10 , C07D493/04 , C07D495/04 , C07D513/04 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61P31/12 , A61K45/06
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：EP3492464B1
公开(公告)日：2020-08-19
申请号：EP18215386.6
申请日：2013-07-02
发明人： BJORNSON, Kyla , CANALES, Eda , COTTELL, Jeromy, J. , KARKI, Kapil, Kumar , KATANA, Ashley, Anne , KATO, Darryl , KOBAYASHI, Tetsuya , LINK, John, O. , MARTINEZ, Ruben , PHILLIPS, Barton, W. , PYUN, Hyung-jung , SANGI, Michael , SCHRIER, Adam, James , SIEGEL, Dustin , TAYLOR, James, G. , TRAN, Chinh, Viet , TREJO MARTIN, Teresa, Alejandra , VIVIAN, Randall, W. , YANG, Zheng-Yu , ZABLOCKI, Jeff , ZIPFEL, Sheila
IPC分类号： C07D403/14 , C07D241/36 , C07K5/08 , A61K31/10 , A61K38/06 , A61K38/21 , A61K31/40 , A61K31/47 , A61K31/506 , A61K31/519
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公开(公告)号：EP3309157A1
公开(公告)日：2018-04-18
申请号：EP17190692.8
申请日：2010-05-12
发明人： GUO, Hongyan , KATO, Darryl , KIRSCHBERG, Thorstens A. , LIU, Hongtae , LINK, John O. , MITCHELL, Michael L. , PARRISH, Jay P. , SQUIRES, Neil , SUN, Jianyu , TAYLOR, James , BACON, Elizabeth M. , CANALES, Eda , CHO, Aesop , COTTELL, Jeromy J. , DESAI, Manoj C. , HALCOMB, Randall L. , KRYGOWSKI, Evan S. , LAZERWITH, Scott E. , LIU, Qi , MACKMAN, Richard , PYUN, Hyung-Jung , SAUGIER, Joseph H. , TRENKLE, James D. , TSE, Winston C. , VIVIAN, Randall W. , SCHROEDER, Scott D. , WATKINS, William J. , XU, Lianhong , YANG, Zheng-Yu , KELLAR, Terry , SHENG, Xiaoning , CLARKE, Michael O'Neil Hanrahan , CHOU, Chien-hung , GRAUPE, Michael , JIN, Haolun , MCFADDEN, Ryan , MISH, Michael R. , METOBO, Samuel E. , PHILLIPS, Barton W. , VENKATARAMANI, Chandrasekar , KIM, Chuong U.
IPC分类号： C07D409/14 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D207/16 , C07D495/04 , A61K31/12 , A61P31/12
CPC分类号： C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：EP3699176A2
公开(公告)日：2020-08-26
申请号：EP19215845.9
申请日：2011-11-16
发明人： BACON, Elizabeth M. , COTTELL, Jeromy J. , KATANA, Ashley Anne , KATO, Darryl , KRYGOWSKI, Evan S. , LINK, John O. , TAYLOR, James , TRAN, Chinh Viet , TREJO MARTIN, Teresa Alejandra , YANG, Zheng-Yu , ZIPFEL, Sheila
IPC分类号： C07D403/14 , C07D405/14 , C07D417/14 , C07D471/08 , C07D491/10 , C07D493/04 , C07D495/04 , C07D513/04 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61P31/12 , A61K45/06
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：EP3002281B1
公开(公告)日：2017-09-13
申请号：EP15180635.3
申请日：2010-05-12
发明人： GUO, Hongyan , KATO, Darryl , KIRSCHBERG, Thorstens A. , LIU, Hongtae , LINK, John O. , MITCHELL, Michael L. , PARRISH, Jay P. , SQUIRES, Neil , SUN, Jianyu , TAYLOR, James , BACON, Elizabeth M. , CANALES, Eda , CHO, Aesop , COTTELL, Jeromy J. , DESAI, Manoj C. , HALCOMB, Randall L. , KRYGOWSKI, Evan S. , LAZERWITH, Scott E. , LIU, Qi , MACKMAN, Richard , PYUN, Hyung-Jung , SAUGIER, Joseph H. , TRENKLE, James D. , TSE, Winston C. , VIVIAN, Randall W. , SCHROEDER, Scott D. , WATKINS, William J. , XU, Lianhong , YANG, Zheng-Yu , KELLAR, Terry , SHENG, Xiaoning , CLARKE, Michael O'Neil Hanrahan , CHOU, Chien-hung , GRAUPE, Michael , JIN, Haolun , McFADDEN, Ryan , MISH, Michael R. , METOBO, Samuel E. , PHILLIPS, Barton W. , VENKATARAMANI, Chandrasekar , KIM, Chuong U.
IPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/14 , C07D495/04 , A61K31/4184 , A61K45/06 , C07D471/08 , C07F5/02 , C07D413/14 , A61K31/4025 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/113 , C07D207/16 , A61K31/4188 , A61K31/4178 , A61P31/12
CPC分类号： C07D403/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/435 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/5415 , A61K31/55 , A61K45/06 , A61P31/12 , C07D207/16 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D491/113 , C07D495/04 , C07F5/025
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明提供了药物组合物，其包含：（1）下式的化合物或其药学上可接受的盐; （2）NS5B聚合酶抑制剂; 和（3）NS3蛋白酶抑制剂; （1），（2）和（3）的组合在预防或治疗丙型肝炎或丙型肝炎相关疾病中的用途。
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