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    METHOD RELATING TO SWEETNESS ENHANCEMENT
    1.
    发明公开
    METHOD RELATING TO SWEETNESS ENHANCEMENT 审中-公开
    VERFAHREN ZUR VERBESSERUNG DERSÜSSE

    公开(公告)号：EP2995950A1

    公开(公告)日：2016-03-16

    申请号：EP15182783.9

    申请日：2007-04-20

    申请人： Givaudan SA

    发明人： SLACK, Jay, Patrick ,  SIMONS, Christopher, Todd ,  HANSEN, Chad, Allen

    IPC分类号： G01N33/50 ,  G01N21/64

    CPC分类号： G01N33/5008 ,  G01N21/6428 ,  G01N2333/726

    摘要： We have discovered a method to enhance sweetness comprising the use of a sweetener at a sub-to near- threshold concentration which is used in combination with a suprathreshold concentration of another sweetener. The sweetener used at the near-threshold concentration is selected based on its likely binding site in the human sweet taste receptor. The invention relates to the identification of agents that can modulate the taste response in humans (such as sweet taste enhancers) through assays based on a novel sweet receptor protein, heterologous expression systems containing nucleic acid constructs forming said novel sweet receptor protein, and the use of the novel sweet receptor protein in screening.

    摘要翻译： 我们已经发现了一种增强甜味的方法，其包括使用与阈值以下阈值浓度的甜味剂，其与另一甜味剂的阈值浓度组合使用。 基于其在人类甜味受体中可能的结合位点选择以阈值附近浓度使用的甜味剂。 本发明涉及通过基于新的甜型受体蛋白质的测定法，含有形成所述新的甜型受体蛋白质的核酸构建体的异源表达系统以及使用该方法的鉴定，可以调节人类的味觉反应（例如甜味增强剂） 的新型甜型受体蛋白在筛选中。

    N-SUBSTITUTED P-MENTHANE CARBOSAMIDED
    7.
    发明公开
    N-SUBSTITUTED P-MENTHANE CARBOSAMIDED 有权
    的N-取代的对 - 薄荷烷

    公开(公告)号：EP1685093A1

    公开(公告)日：2006-08-02

    申请号：EP04761978.8

    申请日：2004-10-28

    申请人： Givaudan SA

    发明人： GALOPIN, Christophe ,  KRAWEC, Pablo, Victor ,  SLACK, Jay, Patrick ,  TIGANI, Lori

    IPC分类号： C07C233/57

    CPC分类号： C07C255/60 ,  A61K8/42 ,  A61K2800/244 ,  A61Q11/00 ,  A61Q19/00 ,  C07C233/60 ,  C07C233/61 ,  C07C255/42 ,  C07C255/44 ,  C07C311/46 ,  C07C2601/14

    摘要： Compounds of the formula (I) give a cooling sensation to the mouth and skin. In Formula I, m is 0 or 1, Y and Z are selected independently from the group consisting of H, OH, C1-C4 straight or branched alkyl, or, a C1-C4 straight or branched alkoxy, X is (CH2)n-R, where n is 0 or 1 and R is a group with non-bonding electrons, with the provisos that: (a) when Y and Z are H, X is not F, OH, MeO or NO2 in the 4-position and is not OH in the 2 or 6-position; (b) when Y or Z is H then X, Y and Z are such that (i) the groups in the 3- and 4-positions are not both OMe, (ii) the groups in the 4- and 5-positions are not both OMe, (iii) the groups in 3- and 5-positions are not OMe if the group in the 4-position is OH, and (iv) the groups in the 3- and 5-positions are not OH if the group in the 4-position is methyl. The compounds give a cooling sensation up to ten times more powerful than the best current commercial materials.