公开(公告)号：EP0912555A1

公开(公告)日：1999-05-06

申请号：EP97928243.0

申请日：1997-06-19

申请人： GLAXO GROUP LIMITED

发明人： ALLEN, David, George ,  ELDRED, Colin, David ,  JUDKINS, Brian, David Glaxo Wellcome plc ,  MITCHELL, William, Leonard

IPC分类号： A61K31 ,  C07D401 ,  C07D413 ,  C07D453

CPC分类号： C07D401/14 ,  C07D413/14 ,  C07D453/02

摘要： The invention relates to compounds of formula (I) or a salt, solvate, or physiologically functional derivative thereof, in which X represents either CH2-CH2 or CH=CH; Y represents a group (a) or (b); R0 represents SO¿2?Me or CONH2, and R?1¿ represents SO¿2?Me, to processes for their preparation, to pharmaceutical compositions containing such compounds and to their use in medicine, particularly in the treatment of thrombotic disorders.

公开(公告)号：EP2421835A1

公开(公告)日：2012-02-29

申请号：EP10714307.5

申请日：2010-04-22

申请人： Glaxo Group Limited

发明人： ALLEN, David, George ,  COE, Diane, Mary ,  COOPER, Anthony, William, James ,  GORE, Paul, Martin ,  HOUSE, David ,  SENGER, Stefan ,  SOLLIS, Steven, Leslie ,  VILE, Sadie ,  WILSON, Caroline

IPC分类号： C07D231/40 ,  A61K31/415 ,  A61P11/06

CPC分类号： C07D231/40

摘要： The present invention relates to amide compounds, processes for their preparation, pharmaceutical compositions containing these compounds and to their use in the treatment of disorders, conditions or disorders such as allergic disorders, inflammatory disorders and disorders of the immune system.

摘要翻译： 本发明涉及酰胺化合物，其制备方法，含有这些化合物的药物组合物及其在治疗诸如变态反应性疾病，炎性疾病和免疫系统疾病的病症，病症或病症中的用途。

公开(公告)号：EP0799223B1

公开(公告)日：1999-06-09

申请号：EP95942704.8

申请日：1995-12-21

申请人： GLAXO GROUP LIMITED

发明人： ALLEN, David, George ,  ELDRED, Colin, David ,  MITCHELL, William, Leonard

IPC分类号： C07D401/14 ,  A61K31/415

CPC分类号： C07D401/14

摘要： The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof, in which: X represents either CH2-CH2 or CH=CH, and Y represents a hydrogen atom or a phenylmethyl group, wherein the phenyl group is optionally substituted by one or more halogen atoms. Compounds of formula (I) inhibit blood platelet aggregation.

公开(公告)号：EP0799223A1

公开(公告)日：1997-10-08

申请号：EP95942704.0

申请日：1995-12-21

申请人： GLAXO GROUP LIMITED

发明人： ALLEN, David, George ,  ELDRED, Colin, David ,  MITCHELL, William, Leonard

IPC分类号： A61K ,  C07D ,  C07D401 ,  A61K31 ,  A61P7

CPC分类号： C07D401/14

摘要： The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof, in which: X represents either CH2-CH2 or CH=CH, and Y represents a hydrogen atom or a phenylmethyl group, wherein the phenyl group is optionally substituted by one or more halogen atoms. Compounds of formula (I) inhibit blood platelet aggregation.

摘要翻译： 本发明提供了式（I）化合物及其药学上可接受的衍生物，其中：X代表CH 2 -CH 2或CH = CH，Y代表氢原子或苯甲基，其中苯基任选被一个 或更多的卤素原子。 式（I）化合物抑制血小板聚集。

公开(公告)号：EP0948509A1

公开(公告)日：1999-10-13

申请号：EP97953888.0

申请日：1997-12-22

申请人： GLAXO GROUP LIMITED

发明人： COX, Brian ,  KEELING, Suzanne, Elaine ,  ALLEN, David, George ,  REDGRAVE, Alison, Judith ,  BARKER, Michael, David ,  HOBBS, Heather ,  ROPER, Thomas, Davis, IV ,  GEDEN, Joanna, Victoria OSI Pharmaceuticals

IPC分类号： C07D ,  A61K31 ,  A61P11 ,  A61P29 ,  C07D473 ,  C07H7 ,  C07H13 ,  C07H15 ,  C07H19

CPC分类号： C07D473/00 ,  C07H19/16 ,  Y10S514/826 ,  Y10S514/851 ,  Y10S514/885 ,  Y10S514/921 ,  Y10S514/925

摘要： There are provided according to the invention novel compounds of formula (I) wherein R?1, R2 and R3¿ are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.