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公开(公告)号：EP4389908A2
公开(公告)日：2024-06-26
申请号：EP24171392.4
申请日：2020-08-06
发明人： IHNKEN, Leigh Anne , KARPIAK, Joel , KEMMLER, Stefan Jochen , KOWARIK, Michael Thomas , MELBY, Joel , OLLIS, Anne , QUEBATTE, Julien Laurent
IPC分类号： C12P21/00
CPC分类号： C12N9/1051 , C12P21/005 , Y02A50/30
摘要： The present disclosure provides mutated PglB oligosaccharyltransferase enzymes that have the ability to efficiently catalyze the transfer of a saccharide from a lipid carrier to an asparagine reissue in a glycosylation motif on a protein. Also provided are polynucleotides encoding the mutated PglB oligosaccharyltransferase enzymes, host cells capable of expressing the engineered PglB oligosaccharyltransferase enzymes, and methods of using the engineered PglB oligosaccharyltransferase enzymes to make N-glycosylated proteins. Also provided are N-glycosylated proteins that are made using the engineered PglB oligosaccharyltransferase enzymes.
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公开(公告)号：EP4171624A1
公开(公告)日：2023-05-03
申请号：EP21731533.2
申请日：2021-06-17
IPC分类号： A61K39/104 , A61K47/68 , C07K14/21 , C12N9/10 , A61K38/46 , A61K39/108 , A61K39/385 , A61K47/64 , C07K14/705
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公开(公告)号：EP3365004A1
公开(公告)日：2018-08-29
申请号：EP16784182.4
申请日：2016-10-19
发明人： FERON, Christiane Marie-Paule Simone Jeanne , KEMMLER, Stefan Jochen , KOWARIK, Michael Thomas , QUEBATTE, Julien Laurent
IPC分类号： A61K39/104 , A61K39/385 , C07K14/21 , A61P31/04 , A61K39/00
CPC分类号： A61K39/104 , A61K39/385 , A61K45/06 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/6068 , A61K2039/6087 , A61K2039/64 , C07K14/21 , C07K2319/00 , Y02A50/47
摘要： The present invention discloses a conjugate comprising an antigen (for example a saccharide antigen) covalently linked to a Pseudomonas aeruginosa PcrV carrier protein comprising an amino acid sequence which is at least 80% identical to the sequence of SEQ ID NO:1-4, wherein the antigen is linked (either directly or through a linker) to an amino acid residue of the P. aeruginosa PcrV carrier protein. The invention also discloses Pseudomonas aeruginosa PcrV proteins that contain glycosylation site consensus sequences.
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公开(公告)号：EP4168040A1
公开(公告)日：2023-04-26
申请号：EP21733220.4
申请日：2021-06-17
IPC分类号： A61K39/112 , C12N15/70 , C07K14/24 , C07K14/25 , C07K14/21 , A61K39/104 , A61K39/385
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5.发明公开
公开(公告)号：EP4245320A3
公开(公告)日：2023-11-22
申请号：EP23176994.4
申请日：2016-08-24
发明人： POOLMAN, Jan Theunis , ABBANAT, Darren Robert , YON, Patricia Ibarra , HERMANS, Peter Wilhelmus , KOWARIK, Michael Thomas , WETTER, Michael Lukas , KEMMLER, Stefan Jochen , HAUPTLE, Micha Andres , GAMBILLARA, Veronica , MALLY, Manuela , JACQUEMYN, Bert
摘要： Compositions and methods are described for inducing an immune response against extra-intestinal pathogenic Escherichia coli (ExPEC) to thereby provide immune protection against diseases associated with ExPEC. In particular, compositions and methods are described for using conjugates of E. coli polysaccharide antigens O25B, O1A, 02, and O6A covalently bound to a detoxified exotoxin A of Pseudomonas aeruginosa (EPA) carrier protein as vaccines for the prevention of invasive ExPEC disease caused by ExPEC serotypes O1A, 02, O6A and O25B.
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6.发明公开
公开(公告)号：EP4245320A2
公开(公告)日：2023-09-20
申请号：EP23176994.4
申请日：2016-08-24
发明人： POOLMAN, Jan Theunis , ABBANAT, Darren Robert , YON, Patricia Ibarra , HERMANS, Peter Wilhelmus , KOWARIK, Michael Thomas , WETTER, Michael Lukas , KEMMLER, Stefan Jochen , HAUPTLE, Micha Andres , GAMBILLARA, Veronica , MALLY, Manuela , JACQUEMYN, Bert
IPC分类号： A61K47/64
摘要： Compositions and methods are described for inducing an immune response against extra-intestinal pathogenic Escherichia coli (ExPEC) to thereby provide immune protection against diseases associated with ExPEC. In particular, compositions and methods are described for using conjugates of E. coli polysaccharide antigens O25B, O1A, 02, and O6A covalently bound to a detoxified exotoxin A of Pseudomonas aeruginosa (EPA) carrier protein as vaccines for the prevention of invasive ExPEC disease caused by ExPEC serotypes O1A, 02, O6A and O25B.
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