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公开(公告)号：EP1851236B1
公开(公告)日：2010-08-04
申请号：EP06727595.8
申请日：2006-01-13
发明人： CULIC, Ognjen , BOSNAR, Martina , MARJANOVIC, Nikola , JELIC, Dubravko , ALIHODZIC, Sulejman , VELA, Vanja , MARUSIC-ISTUK, Zorica , ERAKOVIC, Vesna , BOSNJAK, Berislav , HRVACIC, Boska , TOMASKOVIC, Marija , MUNIC, Vesna , IVETIC, Vanesa , HUTINEC, Antun , KRAGOL, Goran , LELJAK, Marija
IPC分类号： C07H17/00 , A61K31/7048 , C07H17/08 , A61P29/00 , A61K31/7052
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公开(公告)号：EP1846387A2
公开(公告)日：2007-10-24
申请号：EP06765427.7
申请日：2006-01-13
发明人： HUTINEC, Antun , RUPCIC, Renata , CEMPUH KLONKAY, Andreja , BOSNJAK, Berislav , FILIPOVIC SUCIC, Anita , MARKOVIC, Stribor , HRVACIC, Boska , MALNAR, Ivica , MERCEP, Mladen , MESIC, Milan , ELENKOV, Ivaylo Jivkov
IPC分类号： C07D311/56 , C07D493/12 , C07D405/14 , C07D407/14 , C07D409/14 , A61P29/00 , A61P11/06 , A61K31/37 , C07D493/14
CPC分类号： C07D413/12 , A61K47/545 , C07D311/56 , C07D407/06 , C07D407/14 , C07D413/14 , C07H17/00 , C07H17/08
摘要： Certain bis-(coumarin) compounds of formula (VI) as well as the products of thei intramolecular cyclization including pharmaceutically acceptable salts, hydrates, solvates, clathrates, prodrugs, tautomers and stereoisomers thereof are disclosed. Certain processes and intermediates for the preparation of certain bis-(coumarin) compounds, as well as for the use of these compounds as therapeutically active agents in the prophylaxis and treatment of asthma and other inflammatory diseases and conditions in mammals, especially humans are also disclosed.
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公开(公告)号：EP1633771B1
公开(公告)日：2009-07-15
申请号：EP04729157.0
申请日：2004-04-23
发明人： MERCEP, Mladen , MESIC, Milan , TOMASKOVIC, Linda , MARKOVIC, Stribor , HRVACIC, Boska , MAKARUHA, Oresta , POLJAK, Visnja
IPC分类号： C07J1/00 , C07D413/12 , C07D273/00
CPC分类号： C07D273/00 , C07D413/12 , C07D473/04 , C07H17/08 , C07J1/00
摘要： The present invention relates to new compounds represented by Formula (I); wherein M represents a macrolide subunit of the substructure II, Formula (II); L represents the chain of the substructure III, Formula (III); D represents the steroid or nonsteroidal subunit derived from steroid or nonsteroidal (NSAID) drugs with anti-inflammatory activity. The present invention relates also to pharmaceutically acceptable salts and solvates of such prepared compounds, to processe and intermediates for their preparation, as well as to the improved therapeutic action and the use in the treatment of inflammatory diseases and conditions in humans and animals.
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公开(公告)号：EP1851236A2
公开(公告)日：2007-11-07
申请号：EP06727595.8
申请日：2006-01-13
发明人： CULIC, Ognjen , BOSNAR, Martina , MARJANOVIC, Nikola , JELIC, Dubravko , ALIHODZIC, Sulejman , VELA, Vanja , MARUSIC-ISTUK, Zorica , ERAKOVIC, Vesna , BOSNJAK, Berislav , HRVACIC, Boska , TOMASKOVIC, Marija , MUNIC, Vesna , IVETIC, Vanesa , HUTINEC, Antun , KRAGOL, Goran , LELJAK, Marija
IPC分类号： C07H17/00 , A61K31/7048 , C07H17/08 , A61P29/00 , A61K31/7052
摘要： The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides substituted at the 4' position, to their pharmaceutically acceptable derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their activity and use in the treatment of inflammatory diseases and conditions in humans and animals, especially those diseases associated with excessive secretion of TNF-α, IL-1, IL-8, IL-2 or IL-5; and/or inhibitor of excessive lymphocyte proliferation; and/or excessive granulocyte degranulation.
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5.发明授权USE OF 2-THIA-DIBENZO[E,H]AZULENES FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS 有权2-硫杂 - 二苯并USE [E，H]薁用于治疗和预防疾病和病症中枢神经系统的
公开(公告)号：EP1684702B1
公开(公告)日：2007-09-19
申请号：EP04798721.9
申请日：2004-11-03
发明人： MERCEP, Mladen , MESIC, Milan , PESIC, Dijana , OZIMEC LANDEK, Ivana , HRVACIC, Boska , STANIC, Barbara
IPC分类号： A61K31/381 , A61K31/55 , A61K31/00 , A61P25/18 , A61P25/22 , A61P25/06 , A61P25/28 , A61P25/30 , A61P25/00 , A61P15/00 , A61P25/24
CPC分类号： A61K31/00 , A61K31/381 , A61K31/55
摘要： The present invention relates to the use of compounds from the group of 2-thiadibenzo[e, h]azulenes and of their pharmacologically acceptable salts and solvates for the manufacture of a pharmaceutical formulation for the treatment and prevention of diseases, damages and disorders of the central nervous system (CNS) caused by disorders of the neurochemical equilibrium of biogenic amines or other neurotransmitters.
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6.发明授权CONJUGATES OF IMMUNE CELL SPECIFIC MACROLIDE COMPOUNDS WITH ANTI-INFLAMMATORY COMPOUNDS FOR IMPROVED CELLULAR TARGETING OF ANTI-INFLAMMATORY THERAPY 有权免疫细胞特异性大环内酯类了有助于提升细胞抗衰炎化合物偶联物靶向抗炎治疗
公开(公告)号：EP1351973B1
公开(公告)日：2010-03-31
申请号：EP02729470.1
申请日：2002-01-03
发明人： MERCEP, Mladen , MESIC, Milan , TOMASKOVIC, Linda , KOMAC, Marijana , HRVACIC, Boska , MARKOVIC, Stribor
CPC分类号： C07J43/003
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