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公开(公告)号：EP2571891A1
公开(公告)日：2013-03-27
申请号：EP11723863.4
申请日：2011-05-19
申请人： Glycom A/S
发明人： BOUTET, Julien , DEKANY, Gyula , JÀNOSI, Ágnes , PIPA, Gergely , HORVÀTH, Ferenc , KOVÀCS, Krisztián , PÈREZ FIGUEROA, Ignacio , HEDEROS, Markus , SCHROVEN, Andreas , VRASIDAS, Ioannis , KOVÀCS-PÈNZES, Piroska , RISINGER, Christian , DEMKÒ, Sándor , KRÖGER, Lars , RÖHRIG, Christoph
摘要： The present application discloses a method for the crystallization of fucose, characterized in that the crystallization is carried out from a mixture comprising fucose and at least one 6-deoxy sugar selected from 6-deoxy-talose and 6-deoxy-gulose. In one embodiment, the mixture comprises fucose and 6-deoxy-talose.
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公开(公告)号：EP2417144A1
公开(公告)日：2012-02-15
申请号：EP10715192.0
申请日：2010-04-07
申请人： Glycom A/S
发明人： DÉKANY, Gyula , BAJZA, Istvan , BOUTET, Julien , PÉREZ, Ignacio Figueroa , HEDEROS, Markus , HORVATH, Ferenc , KOVÁCS-PÉNZES, Piroska , KRÖGER, Lars , OLSSON, Johan , RÖHRIG, Christoph , SCHROVEN, Andreas , VRASIDAS, Ioannis
IPC分类号： C07H3/06 , C07H15/04 , C07H15/203
CPC分类号： C07H3/06 , C07H1/00 , C07H15/04 , C07H15/203
摘要： The present invention relates to an improved synthesis of a trisaccharide of the formula, novel intermediates used in the synthesis and the preparation of the intermediates.
摘要翻译： 本发明涉及式（1）的三糖的改进合成，用于合成和制备中间体的新中间体。
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3.发明授权A METHOD FOR PREPARATION OF THE TETRASACCHARIDE LACTO-N-NEOTETRAOSE (LNNT) CONTAINING N-ACETYLLACTOSAMINE 有权VERFAHREN ZUR HERSTELLUNG VON TETRASACCHARID-LACTO-N-NEOTETRAOSE（LNNT）MIT N-ACETYLLACTOSAMIN
公开(公告)号：EP2536737B1
公开(公告)日：2017-05-31
申请号：EP11744298.8
申请日：2011-02-21
申请人： Glycom A/S
发明人： BAJZA, István , DEKANY, Gyula , ÁGOSTON, Károly , FIGUEROA PÉREZ, Ignacio , BOUTET, Julien , HEDEROS, Markus , HORVÁTH, Ferenc , KOVÁCS-PÉNZES, Piroska , KRÖGER, Lars , RÖHRIG, Christoph , SCHROVEN, Andreas , VRASIDAS, Ioannis , TRINKA, Péter , KALMÁR, László , KOVÁCS, Imre , DEMKÓ, Sándor , ÁGOSTON, Ágnes , RISINGER, Christian
IPC分类号： C07H15/18 , C07H11/00 , C07H13/04 , A61K31/702
CPC分类号： C07H3/06 , A23L5/00 , A23L7/00 , A23L29/30 , A23L33/10 , A23L33/125 , A23V2002/00 , C07H1/00 , C07H11/00 , C07H13/04 , C07H15/18 , A23V2250/28
摘要： The present invention relates to a new polymorphic form of the tetrasaccharide of formula (I) and the preperation thereof.
摘要翻译： 本发明涉及一种特别是大规模制备四糖乳-N-新四糖（LNnt，式（I））的方法，以及合成中的中间体，即LNnt的新晶型（多晶型物），以及 在药物或营养组合物中的应用。
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公开(公告)号：EP2576578A1
公开(公告)日：2013-04-10
申请号：EP11789282.8
申请日：2011-06-01
申请人： Glycom A/S
发明人： ÁGOSTON, Károly , BAJZA, István , DEKANY, Gyula , TRINKA, Péter , ÁGOSTON, Ágnes , KÁDÁR, Gábor , DEMKÓ, Sándor , PÉREZ FIGUEROA, Ignacio , HEDEROS, Markus , HORVÁTH, Ferenc , SCHROVEN, Andreas , VRASIDAS, Ioannis , KOVÁCS-PÉNZES, Piroska , RISINGER, Christian , KALMÁR, László , PIPA, Gergely , BOUTET, Julien , KRÖGER, Lars , RÖHRIG, Christoph
IPC分类号： C07H3/06 , C07H1/06 , A61K31/702 , A23L1/09 , A23L1/29
摘要： The present invention relates to novel polymorphs of the trisaccharide 2′-O-fucosyllactose (2-FL) of formula (1), methods for producing said polymorphs and their use in pharmaceutical or nutritional compositions.
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公开(公告)号：EP2417144B1
公开(公告)日：2017-08-23
申请号：EP10715192.0
申请日：2010-04-07
申请人： Glycom A/S
发明人： DÉKANY, Gyula , BAJZA, István , BOUTET, Julien , FIGUEROA PÉREZ, Ignacio , HEDEROS, Markus , HORVÁTH, Ferenc , KOVÁCS-PÉNZES, Piroska , KRÖGER, Lars , OLSSON, Johan , RÖHRIG, Christoph , SCHROVEN, Andreas , VRASIDAS, Ioannis
IPC分类号： C07H1/00 , C07H3/06 , C07H15/04 , C07H15/203
CPC分类号： C07H3/06 , C07H1/00 , C07H15/04 , C07H15/203
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6.发明公开N-SUBSTITUTED MANNOSAMINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE 审中-公开N-取代MANNO SAMI衍生物，方法用于生产和使用
公开(公告)号：EP2697239A1
公开(公告)日：2014-02-19
申请号：EP12771248.7
申请日：2012-04-11
申请人： Glycom A/S
摘要： A compound of the formula (I) wherein R
1 is a group removable by hydrogenolysis,and wherein R
2 is OH or R
2 is -NHR
3 wherein R
3 is a group removable by hydrogenolysis. The compound can be made from fructose by a Heyns-rearrangement. The compound can be used then to make - free D-mannosamine or its salts, - D-mannosamine building blocks and mannosamine containing oligo- or polysaccharides, - N-acetyl-D-mannosamine and its hydrates and solvates, - neuraminic acid derivatives and, - viral neuraminidase inhibitors.-
公开(公告)号：EP2593559A1
公开(公告)日：2013-05-22
申请号：EP11736329.1
申请日：2011-07-15
申请人： Glycom A/S
发明人： SCHROVEN, Andreas , CHAMPION, Elise , DEKANY, Gyula , RÖHRIG, Christoph , VRASIDAS, Ioannis , PÉREZ FIGUEROA, Ignacio , HEDEROS, Markus , BOUTET, Julien , ÁGOSTON, Ágnes , KOVÁCS-PÉNZES, Piroska , HORVÁTH, Ferenc , RISINGER, Christian , PIPA, Gergely , DEMKÓ, Sándor , KRÖGER, Lars
IPC分类号： C12P19/26
摘要： The invention relates to a method for the synthesis of compounds of general formula (1A) and salts thereof wherein one of the R groups is an α-sialyl moiety and the other is H, X
1 represents a carbohydrate linker,A is a D-glucopyranosyl unit optionally substituted with fucosyl, R
1 is a protecting group that is removable by hydrogenolysis, the integer m is 0 or 1, by a transsialidation reaction.摘要翻译： 本发明涉及用于合成通式（1A）的化合物及其盐的方法，其中R基团之一是α-唾液酸基部分，另一个是H，X 1表示碳水化合物连接体，A是D- 吡喃葡萄糖基单元任选地被岩藻糖基取代，R 1是可通过氢解除去的保护基，整数m是0或1，通过转酯化反应。
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8.发明公开PRODUCTION OF 6'-O-SIALYLLACTOSE AND INTERMEDIATES 有权HERSTELLUNG VON 6'-O-SIALYLLACTOSE UND ZWISCHENPRODUKTEN DAVON
公开(公告)号：EP2536736A1
公开(公告)日：2012-12-26
申请号：EP11744297.0
申请日：2011-02-21
申请人： Glycom A/S
发明人： PÉREZ FIGUEROA, Ignacio , HORVÁTH, Ferenc , DEKANY, Gyula , ÁGOSTON, Károly , ÁGOSTON, Ágnes , BAJZA, István , BOUTET, Julien , HEDEROS, Markus , KOVÁCS-PÉNZES, Piroska , KRÖGER, Lars , RÖHRIG, Christoph , SCHROVEN, Andreas , VRASIDAS, Ioannis , RISINGER, Christian
CPC分类号： A23L1/308 , A23L33/10 , A23L33/21 , A61K31/702 , C07H1/00 , C07H3/06 , C07H13/04 , C07H15/18
摘要： The present invention relates to a method for preparation of the trisaccharide 6'-0-sialyllactose (formula (I)) or salts thereof as well as intermediates in the synthesis and for the use of 6'-0-sialyllactose salts in pharmaceutical or nutritional compositions.
摘要翻译： 本发明涉及三糖6'-O-唾液乳糖（式（I））或其盐的制备方法以及在药物或营养物质中合成和使用6'-O-唾液酸乳糖盐的中间体 成分。
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公开(公告)号：EP2791349A1
公开(公告)日：2014-10-22
申请号：EP12856808.6
申请日：2012-10-10
申请人： Glycom A/S
CPC分类号： C12P19/26 , C07H15/12 , C07H15/22 , C12N9/88 , C12Y401/01003
摘要： Method of making NANA from NAM, which may itself be made from fructose. The NAM is treated with pyruvic acid or a pyruvate in the presence of a NANA aldolase having at least 70 % sequence similarity or homology to the amino acid sequence of SEQ. ID. NO. 1.
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公开(公告)号：EP2627660A1
公开(公告)日：2013-08-21
申请号：EP11773226.3
申请日：2011-10-13
申请人： Glycom A/S
发明人： SCHROVEN, Andreas , DEKANY, Gyula , RÖHRIG, Christoph , VRASIDAS, Ioannis , FIGUEROA PÉREZ, Ignacio , HEDEROS, Markus , BOUTET, Julien , KRÖGER, Lars , KOVÁCS-PÉNZES, Piroska , HORVÁTH, Ferenc , RISINGER, Christian , PIPA, Gergely
摘要： The present invention provides: in a first aspect, a method for the preparation of L-fucose, wherein L-fucose precursors are produced from pectin and L-fucose is produced from the L-fucose precursors; in a second aspect, a method for the preparation of L-fucose from D-galacturonic acid or a salt thereof, wherein L-fucose precursors are produced from D-galacturonic acid or a salt thereof, and L-fucose is produced from the L-fucose precursors; and an L-fucose precursoras shown in Formula A below, wherein R is a linear or branched chain saturated hydrocarbon group with 1-6 carbon atoms, such as methyl, ethyl,
n -propyl,
i -propyl,
n -butyl,
i -butyl,
s -butyl,
t -butyl,
n -hexyl, etc., preferably a methyl group.
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