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公开(公告)号：EP1419393B1
公开(公告)日：2014-08-13
申请号：EP02753102.9
申请日：2002-08-20
申请人： Glykos Finland Oy
IPC分类号： G01N33/574 , C07H5/06 , A61K39/00 , A61P35/00
CPC分类号： A61K39/39558 , A61K38/1709 , A61K38/45 , A61K39/00 , A61K47/549 , A61K47/6851 , A61K2039/505 , C07H3/06 , C07K16/18 , C12Y204/00 , G01N33/57469 , G01N33/57492
摘要： The present invention describes oligosaccharide sequences, which are specifically expressed by human tumors. The present invention is related to a method of determining an oligosaccharide sequence, which comprises a tumor specific terminal N-acetylglucosamine residue, in a biological sample, the presence of said sequence in said sample being an indication of the presence of cancer. The present invention provides antigenic substances comprising said oligosaccharide sequences in a polyvalent form and it further provides diagnostic agents, pharmaceutical compositions and cancer vaccines comprising said oligosaccharide sequences or substances binding to said oligosaccharide sequences. The present invention is also related to methods for the treatment of cancer.
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2.发明公开
公开(公告)号：EP1680133A2
公开(公告)日：2006-07-19
申请号：EP04791421.3
申请日：2004-10-20
申请人： Glykos Finland Oy
发明人： ANGSTRÖM, Jonas , MILLER-PODRAZA, Halina , PANTZAR, Martina , KARLSSON, Karl-Anders , BLOMQVIST, Maria , HEISKANEN, Annamari , NIEMELÄ, Ritva , HELIN, Jari , NATUNEN, Jari
IPC分类号： A61K31/7028 , A61K31/7012 , A61P31/12 , C07H15/02
CPC分类号： A61K31/7028
摘要： The present invention relates to long branched poly-N-acetyllactosamines and analogous spacer modified divalent sialosides binding to the large binding site of influenza hemagglutinin. The invention further relates to the method for evaluating the potential of a chemical entity to bind to a molecule or molecular complex comprising a large binding site of influenza hemagglutinin. The invention also provides ligands to influenza hemagglutinin for use in the prevention and/or treatment of influenza.
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3.发明公开
公开(公告)号：EP1531832A1
公开(公告)日：2005-05-25
申请号：EP03761605.9
申请日：2003-06-30
申请人： Glykos Finland Oy
发明人： ANGSTRÖM, Jonas , TENEBERG, Susann , SAARINEN, Juhani , SATOMAA, Tero , ROCHE, Niamh , NATUNEN, Jari , MILLER-PODRAZA, Halina , KARLSSON, Karl-Anders , ABUL-MILH, Maan
IPC分类号： A61K31/702 , A61P1/04 , A61P1/12
CPC分类号： G01N33/56922 , A23L33/10 , A23L33/40 , A23V2002/00 , A61K31/702 , A61K45/06 , A61K47/61 , G01N33/566 , G01N33/56905 , G01N33/56911 , G01N33/56916 , Y02A50/473 , Y02A50/475 , A61K2300/00 , A23V2250/28 , A23V2200/32
摘要： The invention provides a therapeutical composition comprising purified fractions of compounds being or containing a pathogen-inhibiting oligosaccharide sequence for use as a medicament. The present invention especially describes an oligosaccharide-containing substance or receptor binding to diarrheagenic Escherichia coli and/or zoonotic Helicobacter species, and use thereof in, e.g., pharmaceutical, nutritional and other compositions for prophylaxis and treatment of conditions due to the presence of Escherichia coli and/or zoonotic Helicobacter species. The invention is also directed to the use of the receptors for diagnostics of Escherichia coli and/or zoonotic Helicobacter species.
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公开(公告)号：EP1871786A1
公开(公告)日：2008-01-02
申请号：EP06725932.5
申请日：2006-04-20
申请人： Glykos Finland Oy
发明人： ÅNGSTRÖM, Jonas , MILLER-PODRAZA, Halina , PANTZAR, Martina , KARLSSON, Karl-Anders , BLOMQVIST, Maria , HEISKANEN, Annamari , NIEMELÄ, Ritva , HELIN, Jari , NATUNEN, Jari , SATOMAA, Tero , AITIO, Olli
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/145 , C07H15/04 , C07H15/26 , C07K7/06 , C07K7/08 , C12N2760/16122 , C12N2760/16134 , G01N33/56983
摘要： The invention relates to the method for evaluating the potential of a chemical entity, such as an antibody, to bind to a peptide epitope derived from the divalent sialoside binding site of hemagglutinin protein of influenza virus. The invention also provides peptide epitopes for use in the prevention and/or treatment of influenza or for the development of such treatment or vaccine against influenza.
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6.发明授权USE OF AT LEAST ONE GLYCOINHIBITOR SUBSTANCE AGAINST INFECTIOUS DISEASES 有权使用至少一个GLYCOINHIBITOR物质预防传染病
公开(公告)号：EP1411952B1
公开(公告)日：2009-04-22
申请号：EP02751212.8
申请日：2002-06-28
申请人： Glykos Finland Oy
发明人： NATUNEN, Jari , MILLER-PODRAZA, Halina , TENEBERG, Susann , ANGSTRÖM, Jonas , KARLSSON, Karl-Anders
IPC分类号： A61K31/702 , A61P1/04 , A61P31/04
CPC分类号： A61K31/7028 , A61K31/739 , Y02A50/473
摘要： The present invention relates to the use of a glycosidase inhibitor for the manufacture of a medicament for the treatment of a disease, wherein glycosidase enzymes hydrolyze glycoconjugates of a patient to reveal neutral glycan receptors of an pathogenic agent, and wherein the revealed neutral glycan receptor comprise a oligosaccharide sequence.
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7.发明授权
公开(公告)号：EP1531832B1
公开(公告)日：2009-04-15
申请号：EP03761605.9
申请日：2003-06-30
申请人： Glykos Finland Oy
发明人： ANGSTRÖM, Jonas , TENEBERG, Susann , SAARINEN, Juhani , SATOMAA, Tero , ROCHE, Niamh , NATUNEN, Jari , MILLER-PODRAZA, Halina , KARLSSON, Karl-Anders , ABUL-MILH, Maan
IPC分类号： A61K31/702 , A61P1/04 , A61P1/12
CPC分类号： G01N33/56922 , A23L33/10 , A23L33/40 , A23V2002/00 , A61K31/702 , A61K45/06 , A61K47/61 , G01N33/566 , G01N33/56905 , G01N33/56911 , G01N33/56916 , Y02A50/473 , Y02A50/475 , A61K2300/00 , A23V2250/28 , A23V2200/32
摘要： The invention provides a therapeutical composition comprising purified fractions of compounds being or containing a pathogen-inhibiting oligosaccharide sequence for use as a medicament. The present invention especially describes an oligosaccharide-containing substance or receptor binding to diarrheagenic Escherichia coli and/or zoonotic Helicobacter species, and use thereof in, e.g., pharmaceutical, nutritional and other compositions for prophylaxis and treatment of conditions due to the presence of Escherichia coli and/or zoonotic Helicobacter species. The invention is also directed to the use of the receptors for diagnostics of Escherichia coli and/or zoonotic Helicobacter species.
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