公开(公告)号：EP3160513B1

公开(公告)日：2020-02-12

申请号：EP15742047.2

申请日：2015-06-26

申请人： Glykos Finland Oy

发明人： HELIN, Jari ,  SAARINEN, Juhani ,  SATOMAA, Tero ,  EKHOLM, Filip S.

IPC分类号： A61K47/68 ,  A61K47/54 ,  A61P35/00 ,  A61P35/02

公开(公告)号：EP2852610A1

公开(公告)日：2015-04-01

申请号：EP13725617.8

申请日：2013-05-23

申请人： Novartis AG ,  Glykos Finland Oy

发明人： NATUNEN, Jari ,  WESTERHOLM-PARVINEN, Ann ,  SALO, Hanna ,  JOENSUU, Jussi ,  VISKARI, Heli ,  LANDOWSKI, Christopher ,  HUUSKONEN, Anne ,  KANERVA, Anne ,  HÄNNINEN, Anna-Liisa ,  SALOVUORI, Noora ,  PENTTILÄ, Merja ,  SAARINEN, Juhani ,  SALOHEIMO, Markku

IPC分类号： C07K14/435 ,  C12P21/00 ,  C12N9/10

CPC分类号： C12P21/005 ,  C07K14/43545 ,  C07K16/00 ,  C07K2319/01 ,  C12N9/0006 ,  C12N9/1051 ,  C12N9/58 ,  C12N9/88 ,  C12N15/52 ,  C12N15/80

摘要： Described herein are compositions including filamentous fungal cells, such as Trichoderma fungal cells, having reduced protease activity and expressing fucosylation pathway. Further described herein are methods for producing a glycoprotein having fucosylated N-glycan, using genetically modified filamentous fungal cells, for example, Trichoderma fungal cells, as the expression system.

摘要翻译： 本文描述的是包括丝状真菌细胞，例如木霉真菌细胞，具有降低的蛋白酶活性和表达岩藻糖基化途径的组合物。 本文进一步描述了使用遗传修饰的丝状真菌细胞（例如木霉属真菌细胞）作为表达系统来生产具有岩藻糖基化N-聚糖的糖蛋白的方法。

公开(公告)号：EP2370475A1

公开(公告)日：2011-10-05

申请号：EP09832997.2

申请日：2009-12-18

申请人： Glykos Finland Oy

发明人： SAARINEN, Juhani ,  NIEMELÄ, Ritva ,  HELIN, Jari ,  NATUNEN, Jari ,  HILTUNEN, Jukka

IPC分类号： C08B37/00 ,  A23K1/06 ,  A23L1/09 ,  A61K31/715 ,  A61K36/064 ,  C12P19/04 ,  C12N1/16

CPC分类号： C12P19/04 ,  A23K20/163 ,  A23L2/52 ,  A23L5/00 ,  A23L29/30 ,  A23L31/10 ,  A23L33/10 ,  A23L33/14 ,  C08B37/0003 ,  C08B37/0087

摘要： The present invention is directed to a method of production of an immunostimulatory composition having a saccharide fraction, the method including the steps of hydrolyzes of yeast cells and recovering the soluble fraction. The saccharide fraction having composition thus obtained may be incorporated as a food or beverage component or be used as a pharmaceutical for treatment of specific conditions.

公开(公告)号：EP2315828A2

公开(公告)日：2011-05-04

申请号：EP09784152.2

申请日：2009-07-13

申请人： SUOMEN PUNAINEN RISTI VERIPALVELU ,  Glykos Finland Oy

发明人： IMPOLA, Ulla ,  TIITTANEN, Minna ,  MIKKOLA, Milla ,  PARTANEN, Jukka ,  NATUNEN, Jari ,  SATOMAA, Tero ,  SAARINEN, Juhani

IPC分类号： C12N5/0735 ,  C07K14/47

CPC分类号： C12N15/873 ,  C12N5/0606 ,  C12N5/0696 ,  C12N2500/90 ,  C12N2501/115 ,  C12N2533/50

摘要： The invention relates to a method for culturing human embryonic stem cells (hESCs) and/or induced pluripotent stem (iPS) cells on a lectin. The invention relates also to the use of a lectin in a method for culturing human embryonic stem cells (hESCs) and/or induced pluripotent stem (iPS) celts and a culture medium composition containing a lectin attached on the culturing plates.

公开(公告)号：EP2852610B1

公开(公告)日：2018-07-11

申请号：EP13725617.8

申请日：2013-05-23

申请人： Glykos Finland Oy

发明人： NATUNEN, Jari ,  WESTERHOLM-PARVINEN, Ann ,  SALO, Hanna ,  JOENSUU, Jussi ,  VISKARI, Heli ,  LANDOWSKI, Christopher ,  HUUSKONEN, Anne ,  KANERVA, Anne ,  HÄNNINEN, Anna-Liisa ,  SALOVUORI, Noora ,  PENTTILÄ, Merja ,  SAARINEN, Juhani ,  SALOHEIMO, Markku

IPC分类号： C07K14/435 ,  C12P21/00 ,  C12N9/10

CPC分类号： C12P21/005 ,  C07K14/43545 ,  C07K16/00 ,  C07K2319/01 ,  C12N9/0006 ,  C12N9/1051 ,  C12N9/58 ,  C12N9/88 ,  C12N15/52 ,  C12N15/80

摘要： Described herein are compositions including filamentous fungal cells, such as Trichoderma fungal cells, having reduced protease activity and expressing fucosylation pathway. Further described herein are methods for producing a glycoprotein having fucosylated N-glycan, using genetically modified filamentous fungal cells, for example, Trichoderma fungal cells, as the expression system.

公开(公告)号：EP2167674B1

公开(公告)日：2018-04-18

申请号：EP08775485.9

申请日：2008-06-13

申请人： Glykos Finland Oy ,  Hankkija Oy

发明人： NIEMELÄ, Ritva ,  SAARINEN, Juhani ,  HELIN, Jari ,  WAKKINEN, Janica

IPC分类号： A23K20/163 ,  A23L29/30 ,  A61K31/715 ,  A61K36/064 ,  A61P1/00 ,  C07H1/08 ,  C12P19/04

CPC分类号： C12P19/04 ,  A23K20/163 ,  A23L5/00 ,  A23L29/30 ,  A23L31/10 ,  A61K36/064 ,  C07H1/08

摘要： The present invention is directed to a novel saccharide composition isolated from a yeast culture. The invention is also directed to yeast cell based saccharide composition with increased water-solubility. The saccharide compositions disclosed in the invention can be used as nutritional or pharmaceutical additives or as part of nutritional or pharmaceutical composition in order to promote the health of an animal or human subject to which said composition is administered. The invention is also directed to methods of producing said saccharide compositions.

公开(公告)号：EP2370475B1

公开(公告)日：2017-02-15

申请号：EP09832997.2

申请日：2009-12-18

申请人： Glykos Finland Oy

发明人： SAARINEN, Juhani ,  NIEMELÄ, Ritva ,  HELIN, Jari ,  NATUNEN, Jari ,  HILTUNEN, Jukka

IPC分类号： A23K10/38 ,  A23L29/30

CPC分类号： C12P19/04 ,  A23K20/163 ,  A23L2/52 ,  A23L5/00 ,  A23L29/30 ,  A23L31/10 ,  A23L33/10 ,  A23L33/14 ,  C08B37/0003 ,  C08B37/0087

摘要： The present invention is directed to a method of production of an immunostimulatory composition having a saccharide fraction, the method including the steps of hydrolyzes of yeast cells and recovering the soluble fraction. The saccharide fraction having composition thus obtained may be incorporated as a food or beverage component or be used as a pharmaceutical for treatment of specific conditions.

摘要翻译： 本发明涉及生产具有糖类成分，包括酵母细胞的水解步骤的方法，回收可溶性部分的免疫刺激组合物的方法。 由此获得的糖类成分具有组合物可作为食物或饮料组分或用作用于治疗特定病症的药物。

公开(公告)号：EP2986713A1

公开(公告)日：2016-02-24

申请号：EP14721912.5

申请日：2014-04-16

申请人： Glykos Finland Oy

发明人： MIKKOLA, Milla ,  OTONKOSKI, Timo ,  MONONEN, Heli ,  SATOMAA, Tero ,  SAARINEN, Juhani

IPC分类号： C12N5/074

CPC分类号： C12N5/0696 ,  C12N2506/1307 ,  C12N2510/00 ,  C12N2533/50 ,  G01N33/56966

摘要： The invention relates to a method for generating induced pluripotent stem cells, wherein the method comprises: step a) of inducing non- pluripotent cells to produce a mixture comprising induced pluripotent stem cells and non-pluripotent cells; step b) of contacting the mixture comprising induced pluripotent stem cells and non- pluripotent cells obtainable from step a) with a binding agent, wherein the binding agent is capable of binding an epitope consisting of the non-reducing terminal saccharide structure according to formula (Fucα1-2)
a Galβ1-3HexNAcβ, whereina= 0 or 1 and Hex is either Glc or Gal; and step c) of selecting an induced pluripotent stem cell bound by the binding agent.

公开(公告)号：EP2315828B1

公开(公告)日：2015-07-01

申请号：EP09784152.2

申请日：2009-07-13

申请人： Glykos Finland Oy

发明人： IMPOLA, Ulla ,  TIITTANEN, Minna ,  MIKKOLA, Milla ,  PARTANEN, Jukka ,  NATUNEN, Jari ,  SATOMAA, Tero ,  SAARINEN, Juhani

IPC分类号： C12N5/0735 ,  C07K14/47

CPC分类号： C12N15/873 ,  C12N5/0606 ,  C12N5/0696 ,  C12N2500/90 ,  C12N2501/115 ,  C12N2533/50

公开(公告)号：EP1913385B1

公开(公告)日：2013-08-21

申请号：EP06778525.3

申请日：2006-07-11

申请人： Glykos Finland Oy

发明人： SATOMAA, Tero ,  NATUNEN, Jari ,  HEISKANEN, Annamari ,  BLOMQVIST, Maria ,  OLONEN, Anne ,  SAARINEN, Juhani

IPC分类号： G01N33/50 ,  G01N33/543 ,  G01N33/574 ,  C07H5/06 ,  C08B37/00

CPC分类号： G01N33/5308 ,  C08B37/00 ,  G01N2400/12 ,  G01N2400/38