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1.发明公开
公开(公告)号：EP2522653A4
公开(公告)日：2013-06-12
申请号：EP11731936
申请日：2011-01-06
发明人： KIM SUNG WUK , JUN SUNG SOO , MIN CHANG HEE , KIM YOUNG WOONG , KANG MIN SEOK , OH BYUNG KYU , PARK SE HWAN , KIM YONG EUN , KIM DUCK , LEE JI SUN , OH JU HOON
IPC分类号： C07C279/26 , A61K31/155 , A61P3/10 , A61P35/00 , C07C277/02
CPC分类号： A61K31/155 , A61K31/341 , A61K31/4406 , A61K31/472 , C07C277/04 , C07C279/04 , C07C279/06 , C07C279/08 , C07C279/16 , C07C279/18 , C07C279/26 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D213/38 , C07D307/52 , C07D317/58 , C07D333/20
摘要： A biguanide derivative compound with N4-N5 substitution, which is represented by Formula 1, or a pharmaceutically acceptable salt thereof, a method of preparing the same, and a pharmaceutical composition containing the same as an active ingredient are provided. The biguanide derivative may exhibit excellent effect on activation of AMPK and inhibition of cancer cell proliferation in a low dose, compared with conventional drugs, and thus, may be useful to treat diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovarian syndrome, metabolic syndrome, cancer, etc.
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2.发明公开MODIFIED HUMAN THROMBOPOIETIN POLYPEPTIDE FRAGMENT AND MANUFACTURING METHOD THEREOF 审中-公开改造人血小板生成素多肽片段及其制造方法
公开(公告)号：EP2390261A4
公开(公告)日：2012-11-14
申请号：EP10733639
申请日：2010-01-20
发明人： KIM SUNG WUK , JUN SUNG SOO , PARK SEUNG KOOK , JEONG JAE KAP , LEE SUNG YUL , SONG YEON JUNG , SHIM WON JO
IPC分类号： C07K14/505 , A61K38/17 , C12N15/12 , C12N15/63
CPC分类号： C07K14/515 , A61K38/196
摘要： The present invention provides a modified human thrombopoietin polypeptide fragment that has platelet proliferative activity in vivo and in vitro and enhanced resistance to protease existing in vivo.
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3.发明公开COMPOSITIONS FOR EXTERNAL APPLICATION, CONTAINING ADENOSYL COBALAMIN FOR IMPROVEMENT OF SKIN DISEASES 有权Adenosylcobalamine包括成分对于局部使用，以减轻皮肤疾病
公开(公告)号：EP1957087A4
公开(公告)日：2012-07-11
申请号：EP06799307
申请日：2006-10-18
发明人： SHIN BYUNG CHEOL , SEONG HASOO , LEE AERI , KONG JAE YANG , CHEON HYAE GYEONG , CHO YOUNG SIK , JUN SUNG SOO , JO YOUNG GWAN
IPC分类号： A61K31/714 , A61K9/127 , A61K45/06 , A61P17/00
CPC分类号： A61K31/714 , A61K9/0014 , A61K9/06 , A61K9/127 , A61K9/7023 , A61K45/06 , A61K2300/00
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4.发明公开MODIFIED HUMAN TUMOR NECROSIS FACTOR RECEPTOR-1 POLYPEPTIDE OR FRAGMENT THEREOF AND METHOD FOR PREPARING SAME 有权修饰的人肿瘤坏死因子受体-1多肽或用于产生它们的片段和过程
公开(公告)号：EP2657252A4
公开(公告)日：2015-02-25
申请号：EP11851725
申请日：2011-12-21
发明人： KIM SUNG WUK , JUN SUNG SOO , PARK SEUNG KOOK , KIM SONG YOUNG , KIM EUN SUN , JEONG JAE KAP , KIM HA NA , SONG YEON JUNG
IPC分类号： C07K14/715 , A61K38/00 , A61K38/17 , A61P35/00 , C07K14/705 , C12N15/12
CPC分类号： C07K14/7151 , A61K38/00 , C07K14/70575
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5.发明公开
公开(公告)号：EP2281557A4
公开(公告)日：2011-08-31
申请号：EP09738963
申请日：2009-04-28
发明人： KIM SUNG WUK , JUN SUNG SOO , JO YOUNG GWAN , KOO JA SEONG , LEE AH RAM , SON JAE WOON , KIM JEONG TAEK
CPC分类号： A61K31/00 , A61K9/2081 , A61K9/2866 , A61K31/41 , A61K31/4178
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6.发明公开1,3,5-TRIAZINE-2,4,6-TRIAMINE COMPOUND OR PHARMACEUTICAL ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 有权1,3,5-三嗪-2,4,6-三胺或它们的药学上可接受的盐和药物组合物中以
公开(公告)号：EP2197858A4
公开(公告)日：2011-08-24
申请号：EP08793562
申请日：2008-08-28
发明人： CHEON HYAE GYEONG , KIM KWANG-ROK , RHEE SANG DAL , JUNG WON HOON , LEE JONG-CHEOL , KIM SUNG WUK , JUN SUNG SOO
IPC分类号： C07D251/54 , A61K31/53 , A61P3/06 , A61P35/00 , C07D251/70 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12
CPC分类号： C07D251/70 , A61K31/53 , C07D251/54 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12
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7.发明公开COMBINATION PREPARATION COMPRISING INHIBITOR OF HMG-COA REDUCTASE AND ASPIRIN AND METHOD FOR MANUFACTURING THE SAME 审中-公开HMG COA还原酶和阿司匹林的组合制备及其生产方法
公开(公告)号：EP2180891A4
公开(公告)日：2010-12-29
申请号：EP08793137
申请日：2008-08-08
发明人： KIM SUNG WUK , JUN SUNG SOO , JO YOUNG GWAN , KOO JA SEONG , SUN SANG OUK
CPC分类号： A61K31/35 , A61K31/616 , A61K45/06 , A61K2300/00
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公开(公告)号：EP2736517A4
公开(公告)日：2014-12-24
申请号：EP12818423
申请日：2012-07-26
发明人： JUN SUNG SOO , LEE SOON IM
IPC分类号： A61K31/714 , A61K9/06 , A61K9/127 , A61P17/00
CPC分类号： A61K9/127 , A61K9/0014 , A61K9/06 , A61K31/714 , A61K47/32
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9.发明公开N,N-DIMETHYL IMIDODICARBONIMIDIC DIAMIDE DICARBOXYLATE, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME 有权N，N-二甲基IMIDODICARBONIMID-DIAMID®二羧酸酯，用于生产它，所以药物组合物
公开(公告)号：EP2203418A4
公开(公告)日：2014-05-21
申请号：EP08832662
申请日：2008-09-19
发明人： KIM SUNG WUK , JUN SUNG SOO , JO YOUNG GWAN , KOO JA SEONG , KIM YOUNG WOONG , KIM BYOUNG HA , KIM DUCK
IPC分类号： C07C279/26 , C07C55/08 , C07C55/12 , C07C55/14 , C07C59/245
CPC分类号： C07C279/26 , C07C55/08 , C07C55/12 , C07C55/14 , C07C59/245
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10.发明公开MODIFIED HUMAN TUMOR NECROSIS FACTOR RECEPTOR-1 POLYPEPTIDE OR FRAGMENT THEREOF, AND METHOD FOR PREPARING SAME 有权修饰的人肿瘤坏死因子受体-1多肽或用于产生它们的片段和过程
公开(公告)号：EP2492281A4
公开(公告)日：2013-09-11
申请号：EP10825175
申请日：2010-10-19
发明人： KIM SUNG WUK , JUN SUNG SOO , PARK SEUNG KOOK , KIM SONG YOUNG , KIM EUN SUN , JEONG JAE KAP , KIM HA NA , SONG YEON JUNG
IPC分类号： C07K14/705 , C12N15/28 , C12N15/63
CPC分类号： C07K14/70578
摘要： The present invention relates to a modified human tumor necrosis factor receptor-1 polypeptide to be coupled to a tumor necrosis factor in vivo or ex vivo, or to a fragment thereof. The modified human tumor necrosis factor receptor-1 polypeptide or the fragment thereof according to the present invention exhibit improved resistance against in vivo protease activity, and thus exhibit improved bioavailability and an improved absorption rate.
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