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1.发明公开INSULINOTROPIC PEPTIDE DERIVATIVE WHEREIN ITS N-TERMINAL AMINO ACID IS MODIFIED 审中-公开胰岛素肽修饰N-端氨基酸衍生物
公开(公告)号：EP2176289A4
公开(公告)日：2010-10-27
申请号：EP08778827
申请日：2008-07-16
发明人： SONG DAE HAE , LIM CHANG KI , KIM YOUNG HOON , KWON SE CHANG , LEE GWAN SUN , BAE SUNG MIN , JUNG SUNG YOUB
CPC分类号： C07K14/46 , A61K38/26 , C07K14/57563 , C07K14/605
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公开(公告)号：EP2114438A4
公开(公告)日：2010-09-01
申请号：EP08704601
申请日：2008-01-04
发明人： SONG DAE HAE , LIM CHANG KI , SONG TAE HUN , KIM YOUNG HOON , KWON SE CHANG , LEE GWAN SUN , JUNG SUNG YOUB , CHOI IN YOUNG
IPC分类号： A61K38/28
CPC分类号： C07K14/57563 , A61K38/00 , A61K47/6835 , C07K14/605
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3.发明公开A PHARMACEUTICAL COMPOSITION COMPRISING AN IMMUNOGLOBULIN FC REGION AS A CARRIER 有权药物组合物，为免疫球蛋白Fc区域作为一个载体含有
公开(公告)号：EP1682584A4
公开(公告)日：2008-11-05
申请号：EP04800092
申请日：2004-11-13
发明人： KIM YOUNG MIN , SONG DAE HAE , JUNG SUNG YOUB , KIM CHANG HWAN , CHOI IN YOUNG , KWON SE CHANG , LEE GWAN SUN
CPC分类号： A61K47/68 , A61K47/48369 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/505 , C07K14/535 , C07K14/56 , C07K14/61 , C07K16/46 , C07K19/00 , C07K2317/52 , C07K2317/732 , C07K2317/734 , C07K2319/30
摘要： Disclosed is a novel use of an immunoglobulin Fc fragment, and more particularly, a pharmaceutical composition comprising an immunoglobulin Fc fragment as a carrier. The pharmaceutical composition comprising an immunoglobulin Fc fragment as a carrier remarkably extends the serum half-life of a drug while maintaining the in vivo activity of the drug at relatively high levels. Also, when the drug is a polypeptide drug, the pharmaceutical composition has less risk of inducing immune responses compared to a fusion protein of the immunoglobulin Fc fragment and a target protein, and is thus useful for developing long-acting formulations of various polypeptide drugs.
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4.发明公开IGG FC FRAGMENT FOR A DRUG CARRIER AND METHOD FOR THE PREPARATION THEREOF 有权IGG Fc片段由于F REINENARZNEIMITTELTRûGER及其制造方法
公开(公告)号：EP1682581A4
公开(公告)日：2008-11-05
申请号：EP04800089
申请日：2004-11-13
发明人： JUNG SUNG YOUB , KIM JIN SUN , YANG GEUN HEE , KWON SE CHANG , LEE GWAN SUN
CPC分类号： A61K47/68 , A61K47/48369 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/505 , C07K14/535 , C07K14/56 , C07K14/61 , C07K16/46 , C07K19/00 , C07K2317/52 , C07K2317/732 , C07K2317/734 , C07K2319/30
摘要： Disclosed is a novel use of an immunoglobulin Fc fragment, and more particularly, a pharmaceutical composition comprising an immunoglobulin Fc fragment as a carrier. The pharmaceutical composition comprising an immunoglobulin Fc fragment as a carrier remarkably extends the serum half-life of a drug while maintaining the in vivo activity of the drug at relatively high levels. Also, when the drug is a polypeptide drug, the pharmaceutical composition has less risk of inducing immune responses compared to a fusion protein of the immunoglobulin Fc fragment and a target protein, and is thus useful for developing long-acting formulations of various polypeptide drugs.
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5.发明公开A PHARMACEUTICAL COMPOSITION FOR TREATING CANCER, COMPRISING INTERFERON ALPHA CONJUGATE 有权药物组合物，癌的干扰素α缀合物的治疗
公开(公告)号：EP2753348A4
公开(公告)日：2015-05-27
申请号：EP12830783
申请日：2012-09-05
发明人： JUNG SUNG YOUB , WOO YOUNG EUN , LIM SE YOUNG , CHOI IN YOUNG , LEE JAE HO , KWON SE CHANG , MOON SUNG HWAN , LIU JIAWANG
IPC分类号： A61K38/21 , A61K39/395 , A61K47/30 , A61K47/48 , A61P35/00
CPC分类号： A61K47/642 , A61K9/0019 , A61K31/7068 , A61K38/212 , A61K47/48423 , A61K47/60 , A61K47/68
摘要： A method for preventing or treating a cancer includes administering an anti-cancer pharmaceutical composition including an interferon alpha or a polymer conjugate thereof. The pharmaceutical composition can be co-administered with anti-cancer agents. The interferon alpha conjugate shows a longer in vivo half-life and a more excellent anti-cancer activity than the conventional interferon alpha, and in particular, its co-administration with an anti-cancer agent such as gemcitabine has synergistic inhibitory effects on cancer cell growth and proliferation so as to exhibit a remarkably excellent anti-cancer activity. Further, the anti-cancer pharmaceutical composition has excellent in vivo half-life and anti-cancer activity to greatly reduce administration frequency. Co-administration of an anti-cancer agent and the interferon alpha conjugate having excellent anti-cancer activity reduces administration dose of anti-cancer agent so as to reduce side effects of anti-cancer agent and increase treatment compliance of patient.
摘要翻译： 一种用于预防或治疗癌症的方法包括抗癌药物组合物的施用包含干扰素α或其聚合物缀合物。 所述药物组合物可以共同给药的抗癌剂。 的干扰素α缀合物显示了在体内半衰期和比常规干扰素α更优异的抗癌活性的时间越长，并且特别地，其共同给予含有抗癌剂：如吉西他滨对癌症细胞的协同抑制效果 的生长和增殖，从而显示出显着优异的抗肿瘤活性。 此外，抗癌药物组合物具有优异的体内半衰期和抗癌活性大大降低给药频率。 抗癌剂和具有优异的抗癌活性的干扰素α缀合物的共施用降低抗癌剂的给药剂量，从而减少抗癌剂的副作用和提高患者的治疗顺应性。
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6.发明公开A METHOD FOR THE MASS PRODUCTION OF IMMUNOGLOBULIN FC REGION DELETED INITIAL METHIONINE RESIDUES 有权方法免疫球蛋白Fc-区无启动蛋氨酸批量生产
公开(公告)号：EP1928910A4
公开(公告)日：2010-03-24
申请号：EP06783620
申请日：2006-08-16
发明人： JUNG SUNG YOUB , KIM JIN SUN , SHIN JIN HWAN , KWON SE-CHANG , LEE GWAN-SUN , SONG DAE HAE
IPC分类号： C07K16/00
CPC分类号： C07K16/00 , A61K47/6811 , A61K47/6835 , C07K2317/41 , C07K2317/52
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公开(公告)号：EP1682582A4
公开(公告)日：2008-11-12
申请号：EP04800090
申请日：2004-11-13
发明人： JUNG SUNG YOUB , KIM JIN SUN , PARK YOUNG JIN , CHOI KI-DOO , KWON SE CHANG , LEE GWAN SUN
CPC分类号： A61K47/68 , A61K47/48369 , A61K47/6811 , A61K47/6813 , A61K47/6835 , C07K14/505 , C07K14/535 , C07K14/56 , C07K14/61 , C07K16/46 , C07K19/00 , C07K2317/52 , C07K2317/732 , C07K2317/734 , C07K2319/30
摘要： Disclosed is a novel use of an immunoglobulin Fc fragment, and more particularly, a pharmaceutical composition comprising an immunoglobulin Fc fragment as a carrier. The pharmaceutical composition comprising an immunoglobulin Fc fragment as a carrier remarkably extends the serum half-life of a drug while maintaining the in vivo activity of the drug at relatively high levels. Also, when the drug is a polypeptide drug, the pharmaceutical composition has less risk of inducing immune responses compared to a fusion protein of the immunoglobulin Fc fragment and a target protein, and is thus useful for developing long-acting formulations of various polypeptide drugs.
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