公开(公告)号：EP1861126A4

公开(公告)日：2009-11-18

申请号：EP06748614

申请日：2006-03-22

申请人： HARVARD COLLEGE ,  DANA FARBER CANCER INST INC

发明人： ANDERSON KENNETH C ,  BRADNER JAMES ELLIOTT ,  GREENBERG EDWARD FRANKLIN ,  HIDESHIMA TERU ,  KWIATKOWSKI NICHOLAS PAUL ,  MAZITSCHEK RALPH ,  SCHREIBER STUART L ,  SHAW JARED ,  HAGGARTY STEPHEN J

IPC分类号： A61K31/357 ,  A61K31/335 ,  A61K31/42 ,  A61K31/4965

CPC分类号： A61K38/05 ,  A61K31/35 ,  A61K31/357 ,  A61K31/422 ,  A61K31/4965 ,  A61K31/69 ,  A61K38/50 ,  A61K45/06 ,  A61K49/0008 ,  G01N33/5011 ,  A61K2300/00

公开(公告)号：EP2872125A4

公开(公告)日：2016-02-24

申请号：EP13817396

申请日：2013-07-10

申请人： DANA FARBER CANCER INST INC ,  GEN HOSPITAL CORP DBA

发明人： ANDERSON KENNETH C ,  HIDESHIMA TERU ,  MAZITSCHEK RALPH ,  GORGUN GULLU

IPC分类号： A61K31/136 ,  A61P35/00 ,  C07C223/06 ,  C07C251/48 ,  C07C251/86 ,  C07D233/80

CPC分类号： C07C223/06 ,  A61K31/136 ,  A61K31/15 ,  A61K31/164 ,  A61K31/165 ,  A61K31/216 ,  A61K31/395 ,  A61K31/4166 ,  A61K31/445 ,  A61K31/655 ,  A61K31/69 ,  A61K45/06 ,  C07C251/48 ,  C07C251/86 ,  C07D211/62 ,  C07D233/80 ,  A61K2300/00

摘要： The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, tautomers, stereoisomers, solvates, hydrates, polymorphs, and compositions thereof. Also provided are methods and kits involving the inventive compounds for treating proliferative diseases (e.g., cancers (e.g., breast cancer, prostate cancer, lung cancer, and ovarian cancer), benign neoplasms, angiogenesis, inflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound of the invention may enhance the anti-tumor immune response by inhibiting or eliminating the immune suppression mediated by immune suppressor myeloid cells (MDSCs), inducing apoptosis, and/or inhibit or down-regulate proteins (e.g., epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), estrogen receptor (ER), X-linked inhibitor of apoptosis protein (XIAP), and heat shock protein 90 (Hsp90)) in the subject.

公开(公告)号：EP1565193A4

公开(公告)日：2008-05-21

申请号：EP03768749

申请日：2003-11-06

申请人： DANA FARBER CANCER INST INC

发明人： ANDERSON KENNETH C ,  HIDESHIMA TERU ,  MITSIADES CONSTANTINE S ,  MITSIADES NICHOLAS

IPC分类号： A61K31/00 ,  A61K31/69 ,  A61K31/704 ,  A61K38/05 ,  A61K38/08

CPC分类号： A61K31/69 ,  A61K31/195 ,  A61K31/198 ,  A61K31/573 ,  A61K31/704 ,  A61K38/05 ,  A61K45/06 ,  A61K2300/00