利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

9 条记录 (耗时 0.02 秒)

    ADHESIVE PATCH AND PRODUCTION METHOD THEREFOR
    4.
    发明公开
    ADHESIVE PATCH AND PRODUCTION METHOD THEREFOR 有权
    KLEBEPFLASTER UND HERSTELLUNGSVERFAHRENDAFÜR

    公开(公告)号：EP2878298A1

    公开(公告)日：2015-06-03

    申请号：EP13822452.2

    申请日：2013-07-25

    申请人： Hisamitsu Pharmaceutical Co., Inc.

    发明人： SUZUKI, Masayuki ,  OKUTSU, Hiroaki ,  YASUKOCHI, Takashi ,  TAKADA, Yasunori

    IPC分类号： A61K31/407 ,  A61K9/70 ,  A61K47/12 ,  A61K47/32 ,  A61P25/18

    CPC分类号： A61K47/12 ,  A61K9/7038 ,  A61K9/7046 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7069 ,  A61K31/407 ,  A61K31/55 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  A61M37/00

    摘要： A method for producing a patch comprising a support layer and an adhesive agent layer comprises:
    a mixture preparation step of mixing asenapine or a pharmaceutically acceptable salt thereof with sodium acetate whose particle diameter D 50 at a cumulative volume of 50% in a particle diameter distribution is 40 to 1000 µm, in such a manner that the sodium acetate and sodium diacetate generated from the sodium acetate have a particle diameter D 50 of 10 µm or smaller, thereby obtaining a mixture containing the sodium diacetate and the asenapine or pharmaceutically acceptable salt; and
    an adhesive-agent-layer formation step of forming the adhesive agent layer comprising the sodium diacetate, the asenapine or pharmaceutically acceptable salt, and a pressure-sensitive adhesive base agent, by using an adhesive agent layer composition obtained by mixing the mixture with the pressure-sensitive adhesive base agent.

    摘要翻译： 一种制备包含支持层和粘合剂层的贴剂的方法，包括：混合制备步骤，将粒径D 50为50％的粒径D 50的乙酸钠与其乙酸钠混合，粒径分布 为40〜1000μm，使得由乙酸钠生成的乙酸钠和二乙酸钠的粒径D 50为10μm以下，从而得到含有二乙酸二钠和其可药用盐的混合物; 以及粘合剂层形成步骤，通过使用通过将所述混合物与所述粘合剂层混合而获得的粘合剂层组合物形成包含二乙酸钠，阿替平或其药学上可接受的盐的粘合剂层和压敏粘合剂基剂 压敏胶基剂。