专利检索 ap:("HOECHST MARION ROUSSEL, INC.") AND inv:"BURKHOLDER, Timothy, P." 第 1 页

1.

发明公开
NOVEL CARBOXY SUBSTITUTED CYCLIC CARBOXAMIDE DERIVATIVES 失效
标题翻译： NEW羧基取代的环状羧

公开(公告)号：EP0946545A1

公开(公告)日：1999-10-06

申请号：EP97950690.0

申请日：1997-11-21

申请人： HOECHST MARION ROUSSEL, INC.

发明人： BURKHOLDER, Timothy, P. , MAYNARD, George, D. , KUDLACZ, Elisabeth, M.

IPC分类号： A61K31 , A61P11 , C07D401 , C07D405 , C07D413

CPC分类号： C07D401/06 , C07D401/14 , C07D405/14 , C07D413/14

摘要： The present invention relates to novel carboxy substituted cyclic carboxamide derivatives of formula (1), and stereoisomers and pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, cough, and bronchitis.

2.

发明公开
HETEROCYCLIC SUBSTITUTED PIPERAZINONE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS 失效
标题翻译：杂环取代的PIPERAZONDERIVATE作为速激肽受体拮抗剂

公开(公告)号：EP0815105A1

公开(公告)日：1998-01-07

申请号：EP96905333.0

申请日：1996-02-06

申请人： HOECHST MARION ROUSSEL, INC.

发明人： BURKHOLDER, Timothy, P. , KUDLACZ, Elizabeth, M. , LE, Tieu-Binh

IPC分类号： A61K31 , A61P11 , A61P43 , C07D209 , C07D403

CPC分类号： C07D403/06 , C07D209/20 , C07D403/14

摘要： The present invention relates to substituted piperazinone derivatives of formula (1), stereoisomers, or pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, cough, and bronchitis. The present invention also relates to intermediates useful in the preparation of compounds of formula (1).

3.

发明公开
NOVEL SUBSTITUTED PIPERAZINE DERIVATIVES HAVING TACHYKININ RECEPTOR ANTAGONISTS ACTIVITY 失效
标题翻译：具有速激肽受体拮抗活性的新的取代的哌嗪衍生物

公开(公告)号：EP0830347A1

公开(公告)日：1998-03-25

申请号：EP96911220.0

申请日：1996-03-11

申请人： HOECHST MARION ROUSSEL, INC.

发明人： BURKHOLDER, Timothy, P. , LE, Tieu-Binh , KUDLACZ, Elizabeth, M.

IPC分类号： C07D241 , A61K31 , A61P1 , A61P11 , A61P25 , A61P27 , A61P29 , A61P37 , A61P43 , C07D309 , C07D403

CPC分类号： C07D403/06 , C07D241/08 , C07D309/12

摘要： The present invention relates to substituted piperazine derivatives (herein referred to as compounds or compounds of formula (1), or stereoisomers, or pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, cough, and bronchitis.

4.

发明公开
SUBSTITUTED 4-(1H-BENZIMIDAZOL-2-YL-AMINO)PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES 失效
标题翻译：改进全氟化碳对生物气体交换和程序

公开(公告)号：EP0920425A1

公开(公告)日：1999-06-09

申请号：EP96941334.0

申请日：1996-11-07

申请人： HOECHST MARION ROUSSEL, INC.

发明人： KANE, John, M. , MAYNARD, George, D. , BURKHOLDER, Timothy, P. , BRATTON, Larry, D. , DALTON, Christopher, R. , SANTIAGO, Braulio , KUDLACZ, Elizabeth, M.

IPC分类号： A61K31 , A61P1 , A61P11 , A61P27 , A61P29 , A61P37 , A61P43 , C07D401 , C07D405 , C07D409 , C07D487 , C07D521

CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/14 , C07D405/14 , C07D409/14 , C07D487/04

摘要： The present invention relates to novel substituted piperidine derivatives of formula (1), stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.