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1.发明公开
公开(公告)号：EP0920425A1
公开(公告)日：1999-06-09
申请号：EP96941334.0
申请日：1996-11-07
发明人： KANE, John, M. , MAYNARD, George, D. , BURKHOLDER, Timothy, P. , BRATTON, Larry, D. , DALTON, Christopher, R. , SANTIAGO, Braulio , KUDLACZ, Elizabeth, M.
IPC分类号： A61K31 , A61P1 , A61P11 , A61P27 , A61P29 , A61P37 , A61P43 , C07D401 , C07D405 , C07D409 , C07D487 , C07D521
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/14 , C07D405/14 , C07D409/14 , C07D487/04
摘要： The present invention relates to novel substituted piperidine derivatives of formula (1), stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.
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公开(公告)号：EP0946548A1
公开(公告)日：1999-10-06
申请号：EP97946443.0
申请日：1997-11-03
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/14
摘要： The present invention relates to novel heterocyclic substituted pyrrolidine amide derivatives of formula (1), and stereoisomers and pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, cough, and bronchitis.
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3.发明公开NOVEL SUBSTITUTED PIPERAZINE DERIVATIVES HAVING TACHYKININ RECEPTOR ANTAGONISTS ACTIVITY 失效具有速激肽受体拮抗活性的新的取代的哌嗪衍生物
公开(公告)号：EP0830347A1
公开(公告)日：1998-03-25
申请号：EP96911220.0
申请日：1996-03-11
IPC分类号： C07D241 , A61K31 , A61P1 , A61P11 , A61P25 , A61P27 , A61P29 , A61P37 , A61P43 , C07D309 , C07D403
CPC分类号： C07D403/06 , C07D241/08 , C07D309/12
摘要： The present invention relates to substituted piperazine derivatives (herein referred to as compounds or compounds of formula (1), or stereoisomers, or pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, cough, and bronchitis.
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4.发明公开NOVEL SUBSTITUTED N-METHYL-N-(4-(PIPERIDIN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES 失效新的取代的N-甲基-N-（4-（哌啶-1-基）-2- ARYLBUTYL）苯甲酰胺用于治疗过敏性疾病的
公开(公告)号：EP0882038A1
公开(公告)日：1998-12-09
申请号：EP97905930.0
申请日：1997-01-27
IPC分类号： A61K31 , A61P1 , A61P11 , A61P27 , A61P37 , A61P43 , C07D211 , C07D401 , C07D405 , C07D409 , C07D417
CPC分类号： C07D401/04 , C07D211/22 , C07D211/70 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/06
摘要： The present invention relates to novel substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamide derivatives of formula (I), stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonists. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.
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5.发明公开HETEROCYCLIC SUBSTITUTED PIPERAZINONE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS 失效杂环取代的PIPERAZONDERIVATE作为速激肽受体拮抗剂
公开(公告)号：EP0815105A1
公开(公告)日：1998-01-07
申请号：EP96905333.0
申请日：1996-02-06
CPC分类号： C07D403/06 , C07D209/20 , C07D403/14
摘要： The present invention relates to substituted piperazinone derivatives of formula (1), stereoisomers, or pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, cough, and bronchitis. The present invention also relates to intermediates useful in the preparation of compounds of formula (1).
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