公开(公告)号：EP0689462A1

公开(公告)日：1996-01-03

申请号：EP94909227.0

申请日：1994-03-16

申请人： HOLMES, Michael John ,  NYCOMED IMAGING AS

发明人： AABYE, Arne ,  BERG, Arne ,  DUGSTAD, Harald ,  DYVIK, Kari ,  FOSS, Per, Antonius ,  KLAVENESS, Jo ,  OSTENSEN, Jonny ,  RONGVED, P l ,  STRANDE, Per ,  TOLLESHAUG, Helge

IPC分类号： A61K49

CPC分类号： A61K49/227 ,  A61K49/223

摘要： Microparticulate materials which are capable of chemical generation of gas after formulation with an appropriate carrier liquid, e.g. water for injection, and/or after administration to a subject, e.g. as a result of exposure to blood or other body fluids, may be used as contrast agents in diagnostic imaging, particularly ultrasound and magnetic resonance imaging.

公开(公告)号：EP0689461A1

公开(公告)日：1996-01-03

申请号：EP94909226.0

申请日：1994-03-16

申请人： HOLMES, Michael John ,  NYCOMED IMAGING AS

发明人： BERG, Arne ,  DUGSTAD, Harald ,  FOSS, Per, Antonius ,  KLAVENESS, Jo ,  OSTENSEN, Jonny ,  RONGVED, Pal ,  STRANDE, Per

IPC分类号： A61K9 ,  A61K49

CPC分类号： A61K49/226 ,  A61K49/223

摘要： Oil-in-water emulsions in which the oil phase comprises condensed or dissolved oil-soluble gas/fluid or gas precursor are useful as ultrasound contrast agents. Such products contain insignificant amounts of free gas bubbles or microbubbles in their stored form and exhibit good storage stability, but may be designed to promote rapid microbubble generation immediately before or upon administration.

摘要翻译： 其中油相包含冷凝或溶解的油溶性气体/流体或气体前体的水包油乳液可用作超声造影剂。 这些产品在其储存的形式中含有微不足道的游离气泡或微泡，并且表现出良好的储存稳定性，但可以设计为在施用之前或之后立即促进快速微泡产生。

公开(公告)号：EP0689461B1

公开(公告)日：2000-07-05

申请号：EP94909226.6

申请日：1994-03-16

申请人： NYCOMED IMAGING AS

发明人： BERG, Arne ,  DUGSTAD, Harald ,  FOSS, Per, Antonius ,  KLAVENESS, Jo ,  OSTENSEN, Jonny ,  RONGVED, Pal ,  STRANDE, Per

IPC分类号： A61K49/00

CPC分类号： A61K49/226 ,  A61K49/223

公开(公告)号：EP0964680A1

公开(公告)日：1999-12-22

申请号：EP97945949.0

申请日：1997-11-26

申请人： NYCOMED IMAGING AS ,  COCKBAIN, Julian Roderick Michaelson

发明人： OSTENSEN, Jonny ,  SONSTEVOLD, Anne

IPC分类号： A61K31 ,  A61K45

CPC分类号： A61K45/06 ,  A61K31/00 ,  A61K31/198 ,  A61K31/216

摘要： The present invention describes the use of a nitric oxide synthetase inhibitor or nitric oxide antagonist to reduce or eliminate unwanted physiological effects encountered with the parenteral administration of particulate drugs.