公开(公告)号：EP0689462A1

公开(公告)日：1996-01-03

申请号：EP94909227.0

申请日：1994-03-16

申请人： HOLMES, Michael John ,  NYCOMED IMAGING AS

发明人： AABYE, Arne ,  BERG, Arne ,  DUGSTAD, Harald ,  DYVIK, Kari ,  FOSS, Per, Antonius ,  KLAVENESS, Jo ,  OSTENSEN, Jonny ,  RONGVED, P l ,  STRANDE, Per ,  TOLLESHAUG, Helge

IPC分类号： A61K49

CPC分类号： A61K49/227 ,  A61K49/223

摘要： Microparticulate materials which are capable of chemical generation of gas after formulation with an appropriate carrier liquid, e.g. water for injection, and/or after administration to a subject, e.g. as a result of exposure to blood or other body fluids, may be used as contrast agents in diagnostic imaging, particularly ultrasound and magnetic resonance imaging.

公开(公告)号：EP1009445A2

公开(公告)日：2000-06-21

申请号：EP97945974.0

申请日：1997-11-28

申请人： NYCOMED IMAGING AS

发明人： OEDEGAARSTUEN, Liv Ingrid ,  DYVIK, Kari ,  BJERKNES, Kathrin ,  FAHLVIK, Anne, Kjersti

IPC分类号： A61K49/04

CPC分类号： A61K49/0466

摘要： The invention provides a contrast agent composition, preferably an X-ray contrast medium, comprising vesicles in suspension in an aqueous medium, said vesicles and optionally also said aqueous medium containing an iodinated X-ray contrast agent, characterised in that a dose of said composition containing 100 mgI entrapped in said vesicles contains no more than 8x1012 vesicles.