公开(公告)号：EP0577659A1

公开(公告)日：1994-01-12

申请号：EP92907057.0

申请日：1992-03-28

申请人： HOLMES, Michael John ,  NYCOMED IMAGING AS

发明人： KLAVENESS, Jo ,  RONGVED, P l ,  STRANDE, Per

IPC分类号： A61K38 ,  A61K47 ,  A61K49 ,  A61L15 ,  A61L17 ,  A61L26 ,  A61L27 ,  A61L31 ,  C07C69 ,  C08K5

CPC分类号： C07C69/96 ,  A61K47/26 ,  A61K47/32 ,  A61K47/42 ,  A61K49/223 ,  A61L17/105 ,  A61L26/0019 ,  A61L26/008 ,  A61L26/009 ,  A61L27/18 ,  A61L27/58 ,  A61L31/06 ,  A61L31/148 ,  C08L67/00

摘要： Cross-linking agents containing or adapted to generate methylene diester or diamide groups of formula -(Z)m.Y.X.C(R R ).X.Y.(Z)n- (where each X and Z is selected from -O-, -S- and -NR- (where R is hydrogen or an organic group); each Y is carbonyl, thiocarbonyl, sulphonyl, phosphoryl or a similar acid-forming group; m and n are each zero or 1; and R and R are each hydrogen, an organic group or a group -X.Y(Z)m-, or together form a divalent organic group) are useful in the preparation of substrates containing biodegradable cross-linking groups.

摘要翻译： 描述了含有交联剂或能够将所述二酯或亚甲基的式二酰胺的生成基团的 - （Z）mYXC（R1R2）某个.XY（Z）n - （其中X和Z各自选自-O - ， - S选择 - 和-NR-（其中R是氢或有机基团）;每个Y是羰基，硫代羰基，磺酰基，磷酰基或类似的酸形成基团; m和n各自为0或1;和R 1和R 2是各自为氢 ，有机基团或基团-XY（Z）m-或一起形成二价有机基团。所述试剂可用于制备含有可生物降解的可交联基团的基材。

公开(公告)号：EP0689462A1

公开(公告)日：1996-01-03

申请号：EP94909227.0

申请日：1994-03-16

申请人： HOLMES, Michael John ,  NYCOMED IMAGING AS

发明人： AABYE, Arne ,  BERG, Arne ,  DUGSTAD, Harald ,  DYVIK, Kari ,  FOSS, Per, Antonius ,  KLAVENESS, Jo ,  OSTENSEN, Jonny ,  RONGVED, P l ,  STRANDE, Per ,  TOLLESHAUG, Helge

IPC分类号： A61K49

CPC分类号： A61K49/227 ,  A61K49/223

摘要： Microparticulate materials which are capable of chemical generation of gas after formulation with an appropriate carrier liquid, e.g. water for injection, and/or after administration to a subject, e.g. as a result of exposure to blood or other body fluids, may be used as contrast agents in diagnostic imaging, particularly ultrasound and magnetic resonance imaging.

公开(公告)号：EP0576521A1

公开(公告)日：1994-01-05

申请号：EP92907161.0

申请日：1992-03-28

申请人： NYCOMED IMAGING AS ,  HOLMES, Michael John

发明人： HOLMES, Michael, John ,  KLAVENESS, Jo ,  RONGVED, P l ,  STRANDE, Per

IPC分类号： A61K49 ,  A61K47 ,  C07C69

CPC分类号： A61K49/225 ,  A61K47/26 ,  A61K47/42 ,  A61K49/223 ,  C07C69/96

摘要： Agents de contraste ultrasonographiques comportant des microbulles de gaz ou de précurseur de gaz encapsulées dans une enveloppe protéique, par exemple en sérum-albumine humaine, la protéine étant réticulée par des groupes biodégradables de réticulation, et présentant une stabilité in vivo lors de l'administration, ce qui permet la visualisation ultrasonographique tout en permettant ultérieurement une élimination rapide à partir de l'organisme.

公开(公告)号：EP0660724A1

公开(公告)日：1995-07-05

申请号：EP93919497.0

申请日：1993-09-03

申请人： HOLMES, Michael John ,  NYCOMED AS

发明人： KLAVENESS, Jo ,  RONGVED, P l ,  JOHANSEN, John Henrik ,  FOSS, Per Antonius ,  HOGSET, Anders ,  HVOSLEF, Anne Marie

IPC分类号： A61K49

CPC分类号： A61K49/1821 ,  A61K49/18 ,  A61K49/223

摘要： Proteinaceous gas- or gas precursor-containing microbubble contrast agents, e.g. for use in ultrasound and/or MR imaging, in which the protein matrix is crosslinked by reaction with a bifunctional aldehyde (e.g. a dialdehyde such as glutaraldehyde or an α,β-unsaturated aldehyde such as acrolein) in an aqueous medium at substantially neutral pH exhibit improved in vivo and storage stabilities, particularly if the matrix is also reacted with a Schiff's base reducing agent such as a borohydride. Modification of the size distribution of such crosslinked proteinaceous gas-containing contrast agents, e.g. to reduce the mean size of the microbubbles, further enhances their stability and permits preparation of novel contrast agents having a particularly narrow microbubble size distribution.

公开(公告)号：EP0660724B1

公开(公告)日：1998-07-01

申请号：EP93919497.3

申请日：1993-09-03

申请人： NYCOMED IMAGING AS

发明人： KLAVENESS, Jo ,  RONGVED, P l ,  JOHANSEN, John Henrik ,  FOSS, Per Antonius ,  HOGSET, Anders ,  HVOSLEF, Anne Marie

IPC分类号： A61K49/00

CPC分类号： A61K49/1821 ,  A61K49/18 ,  A61K49/223

摘要： Proteinaceous gas- or gas precursor-containing microbubble contrast agents, e.g. for use in ultrasound and/or MR imaging, in which the protein matrix is crosslinked by reaction with a bifunctional aldehyde (e.g. a dialdehyde such as glutaraldehyde or an α,β-unsaturated aldehyde such as acrolein) in an aqueous medium at substantially neutral pH exhibit improved in vivo and storage stabilities, particularly if the matrix is also reacted with a Schiff's base reducing agent such as a borohydride. Modification of the size distribution of such crosslinked proteinaceous gas-containing contrast agents, e.g. to reduce the mean size of the microbubbles, further enhances their stability and permits preparation of novel contrast agents having a particularly narrow microbubble size distribution.

公开(公告)号：EP0577659B1

公开(公告)日：1996-01-17

申请号：EP92907057.1

申请日：1992-03-28

申请人： NYCOMED IMAGING AS

发明人： KLAVENESS, Jo ,  RONGVED, P l ,  STRANDE, Per

IPC分类号： C07C69/96 ,  A61K49/00

CPC分类号： C07C69/96 ,  A61K47/26 ,  A61K47/32 ,  A61K47/42 ,  A61K49/223 ,  A61L17/105 ,  A61L26/0019 ,  A61L26/008 ,  A61L26/009 ,  A61L27/18 ,  A61L27/58 ,  A61L31/06 ,  A61L31/148 ,  C08L67/00

摘要： Cross-linking agents containing or adapted to generate methylene diester or diamide groups of formula -(Z)m.Y.X.C(R R ).X.Y.(Z)n- (where each X and Z is selected from -O-, -S- and -NR- (where R is hydrogen or an organic group); each Y is carbonyl, thiocarbonyl, sulphonyl, phosphoryl or a similar acid-forming group; m and n are each zero or 1; and R and R are each hydrogen, an organic group or a group -X.Y(Z)m-, or together form a divalent organic group) are useful in the preparation of substrates containing biodegradable cross-linking groups.

公开(公告)号：EP0998308A2

公开(公告)日：2000-05-10

申请号：EP98932332.4

申请日：1998-07-01

申请人： NYCOMED IMAGING AS ,  UNIVERSITY OF CALIFORNIA, SAN FRANCISCO ,  Golding, Louise

发明人： WATSON, Alan ,  WENDLAND, Michael,Univ. of California at San Fco. ,  JYNGE, Per,Univ. of Norway ,  KARLSSON, Jan, Olof,Univ. of Wales College ofMedf ,  BRUROK, Heidi ,  RONGVED, P l ,  SAEED, Maythem,Univ. of California at San Fco

IPC分类号： A61K49/00

CPC分类号： G01R33/5601 ,  A61K49/06

摘要： The invention provides a method of detecting myocardial ischemia in a human or a non-human body, said method comprising administering to said body a physiologically acceptable manganese complex or salt thereof, subjecting said body to a magnetic resonance imaging procedure capable of generating images with time intervals of less than 0.5 seconds and thereafter providing a series of images of the myocardium of said body whereby to identify regions of abnormal blood flow. The method in accordance with the invention is of use not only in detecting myocardial ischemia, but also in discriminating between reversibly and irreversibly injured myocardial tissues, thereby providing important information about myocardial viability, e.g. during or following a severe heart attack or coronary occlusion. The method of the invention also provides an effective means of monitoring reperfusion of the myocardium.

公开(公告)号：EP0996469A1

公开(公告)日：2000-05-03

申请号：EP98930870.5

申请日：1998-06-16

申请人： NYCOMED IMAGING AS ,  Towler, Philip Dean

发明人： HENRICHS, Paul, Mark ,  ERIKSEN, Marten ,  RONGVED, P l ,  GUNTHER, Wolfgang, Hans, Heinrich ,  SNOW, Robert, Allen ,  HOLLISTER, Kenneth, Robert ,  MCINTIRE, Gregory, Lynn

IPC分类号： A61K49/00

CPC分类号： A61K41/00 ,  A61B6/508 ,  A61K49/00 ,  A61K49/0002 ,  A61K49/0034 ,  A61K49/0078 ,  A61K49/0084 ,  A61K49/0091 ,  A61K49/0404 ,  A61K49/0438 ,  A61K49/0466 ,  Y10S977/949

摘要： The invention relates to a method of generating an image of an animate human or non-human animal body or part thereof. The method comprises administering to said body a physiologically tolerable contrast agent comprising a radiation absorbing component and/or a pressure inducing component, exposing said body to radiation, detecting pressure waves generated in said body by said radiation and generating an optoacoustic image therefrom of at least a part of said body containing the administered contrast agent.

公开(公告)号：EP0963209A2

公开(公告)日：1999-12-15

申请号：EP97910518.0

申请日：1997-10-28

申请人： Marsden, John Christopher ,  NYCOMED IMAGING AS

发明人： KLAVENESS, Jo ,  RONGVED, P l ,  H GSET, Anders ,  TOLLESHAUG, Helge ,  GODAL, Aslak ,  CUTHBERTSON, Alan ,  L VHAUG, Dagfinn ,  SOLBAKKEN, Magne

IPC分类号： A61K47 ,  A61K49 ,  A61K51

CPC分类号： A61K49/0058 ,  A61K47/542 ,  A61K47/62 ,  A61K47/6925 ,  A61K49/0043 ,  A61K49/0091 ,  A61K49/223 ,  A61K51/0497 ,  A61K51/088

摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generated material, in which the reporter is coupled or linked to one or more non-bioactive vectors.

公开(公告)号：EP0627942A1

公开(公告)日：1994-12-14

申请号：EP93905527.0

申请日：1993-03-05

申请人： NYCOMED IMAGING AS

发明人： KLAVENESS, Jo ,  REDFORD, Keith ,  RONGVED, P l ,  SOLBERG, Jan ,  STRANDE, Per ,  WIGGEN, Unni Nordby

IPC分类号： A61K47 ,  A61B5 ,  A61B8 ,  A61K49 ,  C08F16 ,  C08F18 ,  C08F20

CPC分类号： A61K49/1821 ,  A61K49/223

摘要： Agents de contraste comprenant des microparticules et/ou des microsphères contenant ou générant du gaz, dans lesquels le polymère est constitué d'un polymère biodégradable contenant des unités de formule -[-(O)m-CO-OC(R1R2)-OC)-(O)n-]- (dans laquelle R1 et R2 représentent chacun hydrogène ou des groupes monovalents organiques liés au carbone ou constituant conjointement un groupe divalent organique lié au carbone, et m et n sont chacun indépendamment zéro ou 1). Ces agents de contraste sont utiles pour des applications diagnostiques telles que l'échographie et l'imagerie par résonance magnétique.