公开(公告)号：EP1357931A2

公开(公告)日：2003-11-05

申请号：EP02736471.0

申请日：2002-01-04

申请人： HUMAN GENOME SCIENCES, INC.

发明人： RUBEN, Steven, M. ,  JIMENEZ, Pablo ,  DUAN, D., Roxanne ,  RAMPY, Mark, A. ,  MENDRICK, Donna ,  ZHANG, Jun ,  NI, Jian ,  MOORE, Paul, A. ,  COLEMAN, Timothy, A. ,  GRUBER, Joachim R. ,  DILLON, Patrick, J. ,  GENTZ, Reiner, L.

IPC分类号： A61K38/00 ,  A01N1/00 ,  A01N43/04 ,  C12P21/04 ,  C07K1/00 ,  C07H21/02

CPC分类号： C07K14/50 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K48/00

摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as 'KGF-2' also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

公开(公告)号：EP1196441A1

公开(公告)日：2002-04-17

申请号：EP00945130.3

申请日：2000-07-03

申请人： Human Genome Sciences, Inc.

发明人： RUBEN, Steven, M. ,  JIMENEZ, Pablo ,  DUAN, D., Roxanne ,  RAMPY, Mark, A. ,  MENDRICK, Donna ,  ZHANG, Jun ,  NI, Jian ,  MOORE, Paul, A. ,  COLEMAN, Timothy, A. ,  GRUBER, Joachim R. ,  DILLON, Patrick, J. ,  GENTZ, Reiner, L.

IPC分类号： C07K14/47 ,  C07K14/475 ,  C12N5/10 ,  C12N15/12 ,  C12N15/16 ,  C12N15/63 ,  C12N15/64 ,  A61K38/16 ,  A61K38/17 ,  A61K38/18

CPC分类号： C07K14/50 ,  A61K38/00

摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as 'KGF-2' also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

摘要翻译： 本发明涉及新鉴定的多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途以及这种多核苷酸和多肽的产生。 更具体地，本发明的多肽是角质形成细胞生长因子，有时在下文中称为“KGF-2”，以前称为成纤维细胞生长因子12（FGF-12）。 本发明还涉及KGF-2促进或加速伤口愈合的治疗用途。 本发明还涉及显示增强的活性，增加的稳定性，更高的产量或更好的溶解度的KGF-2的新型突变形式。