公开(公告)号：EP0812360A1

公开(公告)日：1997-12-17

申请号：EP95910081.0

申请日：1995-01-11

申请人： HUMAN GENOME SCIENCES, INC.

发明人： GREENE, John M. ,  ROSEN, Craig A. ,  KIRKNESS, Ewen F.

IPC分类号： G01N33 ,  A61K35 ,  A61K38 ,  A61K39 ,  A61K48 ,  A61P31 ,  A61P35 ,  A61P43 ,  C07K16 ,  C12N9 ,  C12N15

CPC分类号： C12N9/1085 ,  A61K38/00

摘要： The application discloses the protein sequence for the enzyme human geranylgeranyl pyrophosphate synthetase and the corresponding DNA sequence that encodes it. The application also discusses an antibody prepared against the enzyme, a method of identifying the enzyme and the use of the enzyme as a medicinal.

公开(公告)号：EP0752844A1

公开(公告)日：1997-01-15

申请号：EP94914946.0

申请日：1994-04-29

申请人： HUMAN GENOME SCIENCES, INC. ,  SMITHKLINE BEECHAM CORPORATION

发明人： HASTINGS, Gregg A. ,  ADAMS, Mark D. ,  FRASER, Claire M. ,  LEE, Norman H. ,  KIRKNESS, Ewen F. ,  BLAKE, Judith A. ,  FITZGERALD, Lisa M. ,  DRAKE, Fred H. ,  GOWAN, Maxine

IPC分类号： G01N33 ,  A61K31 ,  A61K38 ,  A61K39 ,  A61K48 ,  A61P19 ,  A61P35 ,  A61P43 ,  C07H21 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N5 ,  C12N9 ,  C12N15 ,  C12P19 ,  C12P21 ,  C12Q1

CPC分类号： C12N9/6472 ,  A61K38/00 ,  C07K16/40

摘要： Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA (RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.

公开(公告)号：EP0749496A1

公开(公告)日：1996-12-27

申请号：EP95909338.0

申请日：1995-01-25

申请人： HUMAN GENOME SCIENCES, INC.

发明人： HASELTINE, William A. ,  RUBEN, Steven M. ,  WEI, Ying-Fei ,  ADAMS, Mark D. ,  FLEISCHMANN, Robert D. ,  FRASER, Claire M. ,  FULDNER, Rebecca A. ,  KIRKNESS, Ewen F. ,  ROSEN, Craig A.

IPC分类号： C12N15 ,  A61K31 ,  A61K38 ,  A61K48 ,  A61P35 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N5 ,  C12P21 ,  C12Q1 ,  C12R1

CPC分类号： C07K14/47 ,  Y10T436/143333

摘要： The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins and a procedure for producing such proteins by recombinant techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The invention provides methods to diagnose alterations in the hMLH1, hMLH2 and hMLH3 genes.